PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

Functional assays demonstrated that DHA-treated cells exhibited increased secretion of TNF, IL1β, ROS, and PD-L1, accompanied by enhanced cytotoxic activity against hepatocellular carcinoma cells in a co-culture system. These findings reveal the molecular mechanisms underlying TAN polarization, and establish DHA as a potent immunomodulatory agent capable of reshaping TANs toward an anti-tumor phenotype.

Therefore, [CoL3] induces G-quadruplex formation in the promoter region of PTGS2, which ultimately inhibits protein expression of COX-2. This means that [CoL3] can be an effective agent for colorectal cancer treatment.

This study highlights CUR's potential in treating EC, particularly in CD47 overexpression cases. These results clarify the molecular interactions and provide a basis for future research on CUR-based therapies targeting EC progression pathways.

This study offers a theoretical basis for the clinical use of Inula helenium in liver cancer treatment and encourages further investigation.

This study confirms that HQH can influence MC through various active components and multiple therapeutic targets.

Cassia-derived flavonoids represent promising multi-target candidates for lung cancer therapy, particularly through modulation of PTGS2, KIT, and XDH. Their favorable interaction profiles and safety predictions warrant further experimental and in vivo validation.

Combination with EP2/EP4 antagonists produced enhanced anti-metastatic effects. These findings establish EVs-derived lncOSLMT as a key regulator of inflammatory PMN formation in the lung and highlight the potential of LF-RES-siRNA nanoparticles as a targeted anti-metastatic therapy in osteosarcoma.

The results of this study indicated that QYD ameliorates IBI through multiple targets and signaling pathways, with the p53 signaling pathway playing a key role in its therapeutic effect.

This multidisciplinary, predictive strategy successfully identified key bioactive compounds in CP and their molecular targets in breast cancer. The study provides crucial mechanistic evidence for CP's therapeutic potential and highlights the power of this integrated approach for drug discovery from TCM (Traditional Chinese Medicine).

Immunofluorescence further demonstrated enhanced renal expression of Nrf2 and GPX4 in LPS-induced AKI. Collectively, these findings suggest that Zn_Gly alleviates LPS-induced AKI by attenuating oxidative stress and ferroptosis through activation of the Nrf2/GPX4 pathway, thereby contributing to improved renal health in geese.

DSigDB database analysis revealed four possible therapeutic drugs for pancreatic cancer: prolinedithiocarbamate, isoliquiritigenin, aspirin, and resveratrol...High-risk pancreatic cancer populations are potentially associated with an immunosuppressive microenvironment. Candidate drugs screened based on LMRGs offer new possibilities for personalized treatment of pancreatic cancer.

In-depth analysis revealed that the therapeutic mechanism of Qibai Pingfei Capsules may involve targeting and regulating the HIF-1α/COX-2 signaling pathway to intervene in the hypoxic stress response, thereby modulating TNF-α-mediated inflammatory cascades. This mechanism effectively modulated hypoxic stress and the inflammatory microenvironment, promoted lung tissue repair, and significantly reduced pulmonary inflammation levels in the rat model of COPD with phlegm-stasis obstructing the lung syndrome.