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GENE:

PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

News alerts, weekly reports and conference planners

11d

Ferroptosis-mediated anticancer activity of endoperoxide-containing steroids derived from Daedaleopsis confragosa via targeting NOS2. (PubMed, Anim Cells Syst (Seoul))

Finally, NOS2 knockdown using siRNA also showed enhanced expression of ferroptosis markers which is the same response observed with the treatment of the compounds. In conclusion, this study suggests that fungal endoperoxide-containing steroids from D. confragosa represent new ferroptosis inducers via targeting NOS2, supporting their potential as anticancer drug candidates.

11 days ago

Journal

HMOX1 (Heme Oxygenase 1) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • SLC7A11 (Solute Carrier Family 7 Member 11) • NOS2 (Nitric Oxide Synthase 2) • CHAC1 (ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

13d

Assessing the involvement of tumor-secreted factors in the inhibition of muscle differentiation. (PubMed, Biochim Biophys Acta Mol Cell Res)

However, mixtures of the 14 most abundant cytokines in CM had minimal effects on CK activity, and tumor-derived PGE2 showed no significant effect on CK activity or muscle cell differentiation. These findings suggest that the observed muscle-wasting effects of cachexia-inducing tumor cells cannot be replicated by the most abundant cytokines present in CM alone, highlighting the need for further research to identify the key tumor-derived factors responsible for cancer-induced muscle wasting.

13 days ago

Journal

PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

15d

Harmine inhibits non-small cell lung cancer growth by targeting phosphodiesterase4D and inducing ferroptosis. (PubMed, Phytomedicine)

Harmine exerts antitumor effects in NSCLC by inducing ferroptosis through direct targeting of PDE4D and suppression of the PI3K-Akt-Nrf2 pathway, highlighting PDE4D as a novel therapeutic target and harmine as a promising candidate for NSCLC treatment.

15 days ago

Journal

GPX4 (Glutathione Peroxidase 4) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • SLC7A11 (Solute Carrier Family 7 Member 11) • PDE4D (Phosphodiesterase 4D) • LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

15d

Prostaglandin E2-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth. (PubMed, Proc Natl Acad Sci U S A)

Furthermore, analysis of single-cell RNA sequencing of nasopharyngeal cancer patients demonstrates preferential expression of the TI-Treg signature genes in Tregs infiltrating the PTGS2hi tumor group compared to the PTGS2lo tumor group. These findings suggest that PGE2-EP2/EP4 signaling is one of the core mechanisms inducing the TI-Treg phenotype in TME for tumor growth.

15 days ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • IL2RA (Interleukin 2 receptor, alpha) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • FOXP3 (Forkhead Box P3) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

15d

Mechanical ventilation amplifies intratracheal lipopolysaccharide-induced plasma and brainstem inflammation in preterm foetal sheep. (PubMed, Brain Commun)

Mechanical ventilation for 24 h after i.t. LPS amplifies markers of systemic and brainstem inflammation but does not further exacerbate histological inflammation or cell death in brainstem respiratory-related centres. The exacerbated inflammation suggests that mechanical ventilation preceded by intrauterine inflammation may impede cardiorespiratory control with adverse effects on spontaneous breathing and cardiovascular function in preterm infants.

15 days ago

Journal

IFNG (Interferon, gamma) • IL6 (Interleukin 6) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL10 (Interleukin 10) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

20d

Assessing the Neurotoxicity of Bisphenol A Using Network Toxicology, Molecular Docking, and Molecular Dynamics Simulation. (PubMed, Int J Toxicol)

Furthermore, molecular dynamics simulations provided insights into the interactions between BPA and key targets (ESR1, TNF, and TP53), supporting the potential conformational stability of these complexes. Collectively, these computational findings contribute to understanding the potential molecular mechanisms of BPA-induced neurotoxicity and are informative for generating hypotheses related to its pathogenesis.

20 days ago

Journal

ER (Estrogen receptor) • TP53 (Tumor protein P53) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

21d

Paeoniflorin Alleviates LPS-Induced Inflammation and Acute Myocardial Injury by Inhibiting PI3K/Akt/ERK-Mediated HIF-1α and TLR4/MyD88/NF-κB Inflammatory Signaling. (PubMed, Mediators Inflamm)

Ultimately, PF ameliorated SIMI by improving cardiac pathological and functional changes and mitigating myocardial injury markers, such as lactate dehydrogenase (LDH), CK-MB, cTnT/TNNT2, TNNI3/cTn-I, and aspartate aminotransferase (AST). Collectively, the PI3K/Akt/ERK-mediated HIF-1α and TLR4/MyD88/NF-κB inflammation signaling appear to be the primary mechanisms through which PF exerts its beneficial effects on SIMI.

21 days ago

Journal • IO biomarker

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • TNFA (Tumor Necrosis Factor-Alpha) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • STAT3 (Signal Transducer And Activator Of Transcription 3) • ICAM1 (Intercellular adhesion molecule 1) • CASP3 (Caspase 3) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • CCL2 (Chemokine (C-C motif) ligand 2) • TLR4 (Toll Like Receptor 4) • IL1B (Interleukin 1, beta) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

22d

Ferroptosis mediated by ferritinophagy is involved in liver injury caused by sepsis. (PubMed, Sci Rep)

(2) In sepsis, the expression of NCOA4 in hepatocytes increased, leading to the degradation of intracellular ferritin through ferritinophagy, an increase in intracellular Fe²⁺ concentration, and the induction of ferroptosis in hepatocytes. Conclusion Ferritinophagy is involved in sepsis-induced liver injury, and inhibiting ferritinophagy can alleviate hepatocyte ferroptosis and mitigate sepsis-induced liver injury.

22 days ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • NCOA4 (Nuclear Receptor Coactivator 4) • SQSTM1 (Sequestosome 1) • GPX4 (Glutathione Peroxidase 4) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

28d

To Explore the Active Components, Targets, and Potential Effects of Emodin in the Treatment of Colorectal Cancer Based on Network Pharmacology. (PubMed, PPAR Res)

Emodin exerts anti-CRC effects via a multitarget, multipathway mechanism, particularly through modulation of the PPARγ-TP53 axis. These findings support emodin's potential as a natural compound for CRC treatment.

28 days ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • MMP9 (Matrix metallopeptidase 9) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • IL1B (Interleukin 1, beta) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

Network Pharmacology and Computational Study to Identify Active Components and Potential Targets of Polygonatum sibiricum for Hepatocellular Carcinoma Treatment. (PubMed, Comb Chem High Throughput Screen)

Baicalein was identified as an active compound targeting five crucial genes to suppress HCC progression, uncovering a new anti-HCC mechanism of P. sibiricum.

1 month ago

Journal

TP53 (Tumor protein P53) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • MMP9 (Matrix metallopeptidase 9) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

Phenolic Extracts of Hulless Barley Grass Alleviate Progression of Colitis-Related Colorectal Cancer by Inhibiting the Overexpression of Wnt/β-Catenin Signaling Pathway. (PubMed, J Food Sci)

In addition, they contribute to the maintenance of a healthier gut microbiota, thereby supporting intestinal barrier function. Together, these findings highlight a promising natural strategy to improve gut health and lower the risk of inflammation-related colorectal cancer.

1 month ago

Journal

EGFR (Epidermal growth factor receptor) • CCND1 (Cyclin D1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • IL1B (Interleukin 1, beta) • NOS2 (Nitric Oxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

Cannabidiol Reprograms Glucose Metabolism in Colorectal Adenocarcinoma by Targeting HIF-1α/LDHA Pathway. (PubMed, Am J Chin Med)

Synergy with the glycolysis inhibitor 2-DG enhanced therapeutic efficacy, which highlighted cannabidiol's potential to overcome metabolic resistance. These findings establish cannabidiol as a novel inhibitor of HIF-1[Formula: see text]/LDHA-driven glycolysis, and thus provide a translational strategy for metabolic vulnerability in COAD.

1 month ago

Journal

LDHA (Lactate dehydrogenase A) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • SLC2A1 (Solute Carrier Family 2 Member 1)