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    GENE:

    PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)

    i
    Other names: PABPC1, Poly(A) Binding Protein Cytoplasmic 1, PABP1, PABPL1, PABPC2, PAB1, Polyadenylate-Binding Protein 1, Poly(A)-Binding Protein, Cytoplasmic, Poly(A) Binding Protein, Cytoplasmic, Poly(A)-Binding Protein 1, PABP-1, PABP
    Associations

    News

    Trials
    2d
    PABPC1 expression in papillary renal cell carcinoma and its significance for survival outcomes. (PubMed, J Genet Eng Biotechnol)
    PABPC1 could serve as a potential prognostic biomarker for individuals with KIRP.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PRCC (Proline Rich Mitotic Checkpoint Control Factor) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    6d
    Integrated Bioinformatics Analysis of Differentially Expressed RNA-Binding Proteins in Human Gliomas. (PubMed, Cell Mol Neurobiol)
    Further, RBPs like RPS8, RPL5, RPS3A, EEF1A1, and EIF4E1B were found to be strongly correlated with patients' overall survival. Taken together, our analyses identified several candidate RBPs which might serve as potential targets for oncological measures against gliomas.
    Journal
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    IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • RPS6 (Ribosomal Protein S6) • YBX1 (Y-Box Binding Protein 1) • CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1) • EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) • RPL5 (Ribosomal Protein L5) • SMAD7 (SMAD Family Member 7) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    26d
    Young-onset hepatocellular carcinoma following double outlet right ventricle surgery without liver congestion: a case report with genetic analysis. (PubMed, Clin J Gastroenterol)
    This case suggests that non-cirrhotic, early-onset HCC may arise in congenital heart disease patients even without hepatic congestion, implying a different mechanism from post-Fontan hepatocarcinogenesis. Genetic factors may contribute, and screening should be considered in high-risk cases regardless of liver function.
    Journal
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    MUC16 (Mucin 16, Cell Surface Associated) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) • HNF1A (HNF1 Homeobox A) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    2ms
    Targeting PABPC1: A Therapeutic Strategy of Natural Ganoderma Meroterpenoid LZ22 against Triple-Negative Breast Cancer Proliferation. (PubMed, Pharmacol Res)
    Furthermore, through structural optimization of LZ22 guided by molecular docking, we identified a derivative (LZ22-4) with enhanced anti-tumor proliferative activity. These findings not only identify PABPC1 as a valuable therapeutic target for TNBC but also provide new opportunities and novel insights for advancing anti-TNBC drug development with LZ22 as a potential drug leading compound.
    Journal
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    NR4A3 (Nuclear receptor subfamily 4 group A member 3) • CD14 (CD14 Molecule) • CDK14 (Cyclin Dependent Kinase 14) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    3ms
    Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer. (PubMed, Front Oncol)
    We identified some differentially expressed genes relevant to oncogenic signaling and immunosuppressive tumor-associated macrophages. These findings provide novel insights into factors affecting prognosis in patients with residual disease after NAC for early-stage TNBC.
    Journal
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    ACTA2 (Actin Alpha 2 Smooth Muscle) • S100A9 (S100 Calcium Binding Protein A9) • CHI3L1 (Chitinase 3-like 1) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) • KRT14 (Keratin 14) • COL3A1 (Collagen Type III Alpha 1 Chain) • IFI27 (Interferon Alpha Inducible Protein 27) • AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) • MMP7 (Matrix metallopeptidase 7) • MYLK (Myosin Light Chain Kinase) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1) • SERPINA3 (Serpin Family A Member 3) • TPM2 (Tropomyosin 2) • RPL22 (Ribosomal Protein L22)
    4ms
    Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinoma. (PubMed, Signal Transduct Target Ther)
    In summary, tumor-derived TACC3 impairs the tumor-killing activity of CD8+ T lymphocytes through PUFA metabolism-associated crosstalk. Targeting TACC3 represents a novel and practicable strategy to augment ICI efficacy against HCC.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • TACC3 (Transforming acidic coiled-coil containing protein 3) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    4ms
    The Acetyltransferase ARD1 Induces Glutathione Synthesis to Facilitate Ferroptosis Evasion in Hepatocellular Carcinoma. (PubMed, Cancer Res)
    ARD1 suppression promoted sorafenib-mediated ferroptosis in HCC patient-derived xenograft tumors with high ARD1 and GCLC expression. Overall, this research uncovers an oxidative stress-ARD1-PABPC1-GCLC axis with a crucial role in GSH metabolic reprogramming and ferroptosis regulation in HCC and reveals a strategy for ferroptosis-based targeted therapy for HCC.
    Journal
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    EIF4G1 (Eukaryotic translation initiation factor 4 gamma, 1) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
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    sorafenib
    4ms
    LINC00467 promotes non-small-cell lung cancer progression by regulating PABPC1 stability which accompanied by changes in Wnt/β-catenin pathway activity. (PubMed, Int J Biol Macromol)
    These findings suggest that LINC00467 may contribute to NSCLC progression through a mechanism involving PABPC1, with the potential to modulate the Wnt/β-catenin pathway. This regulatory axis may provide insight into future therapeutic targets for NSCLC.
    Journal
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    PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    4ms
    A noncanonical cytoplasmic role for BUB1 in restraining DNA damage-induced dsRNA accumulation and sensing within stress granules. (PubMed, Sci Immunol)
    We found increased immune cell infiltration accompanied by elevated type I interferon production from irradiated BUB1-deficient cells caused by enhanced cytoplasmic dsRNA accumulation and activation of the MDA5/MAVS dsRNA-sensing pathway. Mechanistically, we found that after radiation exposure, BUB1 underwent nucleus-to-cytoplasm migration, where it bound and phosphorylated the poly(A)-binding protein PABPC1, which was degraded together with its associated messenger RNAs stored in the stress granules, thereby preventing dsRNA accumulation and activation of the innate immune response.
    Journal
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    CD8 (cluster of differentiation 8) • IFIH1 (Interferon Induced With Helicase C Domain 1) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    4ms
    PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules. (PubMed, Nat Commun)
    This process facilitates the expression of U-rich genes, such as mitophagy-related genes FUNDC1, BNIP3L, thereby maintaining cellular homeostasis and promoting cell survival under adverse conditions. Our findings reveal that PABPC1 SUMOylation connects stress granule assembly with selective U-rich mRNA stabilization and mitophagy, promoting cancer cell stress adaptation.
    Journal
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    BNIP3L (BCL2 Interacting Protein 3 Like) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    5ms
    Target-Specific Potency and Drug-Ability Profile of Flavonoids Against Lung Cancer: An Integrative Multi-Omics Approach for Lead Identification. (PubMed, Drug Dev Res)
    The integrative multi-omics investigation suggested that using PF43 for lung cancer treatment could increase the chances of experimental success. Overall, the systematic computational analyses provide a platform for lead identification and pave the way for precision phytotherapy in current drug discovery.
    Journal
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    CA9 (Carbonic anhydrase 9) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
    5ms
    Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer's disease. (PubMed, J Transl Med)
    We systematically prioritized AD candidate causal genes based on cell type-level and bulk level molecular evidence. The integrative approach enhances our understanding of molecular mechanisms of AD-related genetic variants and facilitates interpretation of AD GWAS results.
    Journal
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    PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
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    imatinib