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    BIOMARKER:

    OXCT1 expression

    i
    Other names: OXCT1, 3-Oxoacid CoA-Transferase 1, SCOT, OXCT, Succinyl-CoA:3-Ketoacid Coenzyme A Transferase 1, Mitochondrial , Somatic-Type Succinyl-CoA:3-Oxoacid CoA-Transferase, Succinyl-CoA:3-Ketoacid-CoA Transferase, 3-Oxoacid CoA Transferase, SCOT-S, Epididymis Secretory Sperm Binding Protein, Succinyl CoA:3-Oxoacid CoA Transferase, 3-Oxoacid CoA Transferase 1
    Entrez ID:
    5019
    almost2years
    Targeting OXCT1-mediated ketone metabolism reprograms macrophages to promote antitumor immunity via CD8+ T cells in hepatocellular carcinoma. (PubMed, J Hepatol)
    In conclusion, our results demonstrate that OXCT1 epigenetically suppresses antitumor immunity, suggesting that suppressing OXCT1 activity in TAMs is an effective approach for treating liver cancer.
    Journal
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    CD8 (cluster of differentiation 8) • OXCT1 (3-Oxoacid CoA-Transferase 1)
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    OXCT1 expression
    almost4years
    CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5. (PubMed, Cell Cycle)
    Circ-OXCT1 promoted SLC1A5 expression by target binding with miR-516b-5p. Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC.
    Journal
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    SLC1A5 (Solute Carrier Family 1 Member 5) • OXCT1 (3-Oxoacid CoA-Transferase 1)
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    OXCT1 expression
    almost4years
    MicroRNA-886 suppresses osteosarcoma cell proliferation and its maturation is suppressed by long non-coding RNA OXCT1-AS1. (PubMed, Bioengineered)
    Western blot showed that OXCT1-AS1 had no effects on the levels of epithelial-mesenchymal transition biomarkers. Overall, OXCT1-AS1 suppresses miR-886 maturation to promote OS cell proliferation.
    Journal
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    OXCT1 (3-Oxoacid CoA-Transferase 1)
    |
    OXCT1 expression