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    BIOMARKER:

    OSBPL1A overexpression

    i
    Other names: OSBPL1A, Oxysterol Binding Protein Like 1A, ORP-1, ORP1, Oxysterol-Binding Protein-Related Protein 1, Oxysterol Binding Protein-Like 1B, OSBP-Related Protein 1, OSBPL1B, Oxysterol-Binding Protein-Related Protein 1 Variant 1, Oxysterol-Binding Protein-Related Protein 1 Variant 2, Oxysterol Binding Protein-Like 1A, OSBPL1A, OSBPL1, OSBP8
    Entrez ID:
    114876
    over2years
    OSBPL10-APOE PATHWAY INCREASES RESISTANCE OF PLATINUM AND PARPI BY REGULATING CHOLESTEROL METABOLISM AND DNA DAMAGE REPAIR IN PDX MODEL OF HRD-POSITIVE HGSOC (IGCS 2023)
    The expression of OSBPL10 in platinum-resistant HRD-positive ovarian cancer patients were significantly higher than that in platinum-sensitive patients. Inhibiting OSBPL10 enhanced the sensitivity to cisplatin and Niraparib of ovarian cancer cells. Apolipoprotein E (APOE), as a target gene of OSBPL10, was involved in lipid transport and lipoprotein metabolism.
    PARP Biomarker
    |
    HRD (Homologous Recombination Deficiency) • CD8 (cluster of differentiation 8) • APOE (Apolipoprotein E)
    |
    HRD • OSBPL1A overexpression
    |
    cisplatin • Zejula (niraparib)
    almost4years
    Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11. (PubMed, J Nanobiotechnology)
    Exo-miR-7-5p derived from BMSCs negatively regulates OSBPL11 by suppressing the phosphorylation of the PI3K/AKT/mTOR signaling pathway, thereby inhibiting AML proliferation and promoting apoptosis. The data will inform the development of AML therapies based on BMSC-derived exosomes.
    Journal
    |
    MIR7 (MicroRNA 7)
    |
    OSBPL1A overexpression • miR-7 expression • miR-7-5p overexpression