^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    ORIN1001

    i
    Other names: ORIN1001, ORIN 1001, ORIN-1001
    Company:
    Fosun Pharma
    Drug class:
    ERN1 inhibitor
    Related drugs:
    8ms
    Evaluation of Oral ORIN1001 in Subjects With Idiopathic Pulmonary Fibrosis (IPF) (clinicaltrials.gov)
    P1, N=24, Suspended, Orinove, Inc. | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    ORIN1001
    8ms
    ORIN1001-C1: Treatment of Patients With Advanced Solid Tumors With Oral Agent ORIN1001 and in Combination With Standard of Care. (clinicaltrials.gov)
    P1/2, N=150, Completed, Orinove, Inc. | Trial completion date: Jan 2023 --> Jan 2025
    Trial completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1)
    |
    HER-2 negative
    |
    ORIN1001
    1year
    ORIN1001 in Patients with Advanced Solid Tumors and Relapsed Refractory Metastatic Breast Cancer (clinicaltrials.gov)
    P1/2, N=58, Completed, Orinove, Inc. | Active, not recruiting --> Completed | N=150 --> 58
    Trial completion • Enrollment change
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HER-2 negative
    |
    albumin-bound paclitaxel • ORIN1001
    1year
    Evaluation of Oral ORIN1001 in Subjects with Idiopathic Pulmonary Fibrosis (IPF) (clinicaltrials.gov)
    P1, N=24, Suspended, Orinove, Inc. | Active, not recruiting --> Suspended
    Trial suspension
    |
    IL6 (Interleukin 6)
    |
    ORIN1001
    1year
    ORIN1001-C1: Treatment of Patients with Advanced Solid Tumors with Oral Agent ORIN1001 and in Combination with Standard of Care. (clinicaltrials.gov)
    P1/2, N=150, Completed, Orinove, Inc. | Active, not recruiting --> Completed | N=350 --> 150
    Trial completion • Enrollment change
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1)
    |
    HER-2 negative
    |
    ORIN1001
    1year
    ORIN1001-C1: Treatment of Patients with Advanced Solid Tumors with Oral Agent ORIN1001 and in Combination with Standard of Care. (clinicaltrials.gov)
    P1/2, N=150, Completed, Orinove, Inc. | Active, not recruiting --> Completed | N=350 --> 150
    Trial completion • Enrollment change
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1)
    |
    HER-2 negative
    |
    ORIN1001
    1year
    Evaluation of Oral ORIN1001 in Subjects with Idiopathic Pulmonary Fibrosis (IPF) (clinicaltrials.gov)
    P1, N=24, Suspended, Orinove, Inc. | Active, not recruiting --> Suspended
    Trial suspension
    |
    IL6 (Interleukin 6)
    |
    ORIN1001
    almost2years
    Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors. (PubMed, Front Pharmacol)
    The necessity of dose adjustments based on these two covariates remains to be validated in a larger population. The first PopPK model of ORIN1001 was successfully constructed, which may provide some important references for future research.
    PK/PD data • Journal • Metastases
    |
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • XBP1 (X-box-binding protein 1)
    |
    ORIN1001
    almost2years
    ORIN1001 in Patients With Advanced Solid Tumors and Relapsed Refractory Metastatic Breast Cancer (clinicaltrials.gov)
    P1/2, N=150, Active, not recruiting, Orinove, Inc. | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Jan 2023 --> Jan 2024
    Trial completion date • Trial primary completion date • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HER-2 negative
    |
    albumin-bound paclitaxel • ORIN1001
    almost2years
    ORIN1001-C1: Treatment of Patients With Advanced Solid Tumors With Oral Agent ORIN1001 and in Combination With Standard of Care. (clinicaltrials.gov)
    P1/2, N=350, Active, not recruiting, Orinove, Inc. | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1)
    |
    HER-2 negative
    |
    ORIN1001
    almost2years
    Evaluation of Oral ORIN1001 in Subjects With Idiopathic Pulmonary Fibrosis (IPF) (clinicaltrials.gov)
    P1, N=24, Active, not recruiting, Orinove, Inc. | Phase classification: P1b --> P1 | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
    Phase classification • Trial completion date • Trial primary completion date
    |
    IL6 (Interleukin 6)
    |
    ORIN1001
    over2years
    ORIN1001 in Patients With Advanced Solid Tumors and Relapsed Refractory Metastatic Breast Cancer (clinicaltrials.gov)
    P1/2, N=150, Active, not recruiting, Orinove, Inc. | Trial completion date: Mar 2023 --> Dec 2023
    Trial completion date • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HER-2 negative
    |
    albumin-bound paclitaxel • ORIN1001