Oral Cancer

These findings provide preliminary insights into how NDRG1 serves as a pivotal regulator driving p-EMT and coordinating niche remodelling. NDRG1 serves as a pivotal regulator driving p-EMT and proangiogenic niche remodelling, representing a potential novel target for the diagnosis and treatment of OSCC.

Pharmacological inhibition of AMPK was associated with reduced DRP1 mitochondrial translocation and diminished mitophagy. These findings collectively uncover that DRP1 contributes to mitophagy and allows OSCC cells to adapt to glucose limitation and overcome associated ROS stress, providing potential mechanistic insights for enhancing the efficiency of targeted therapies strategies.

Integrating intratumoral and peritumoral radiomics enables accurate, non-invasive prediction of TP53 status in PDAC. This model serves as a promising auxiliary tool for individualized treatment planning, warranting further prospective validation.

In vivo studies have indicated the potential efficacy of EGCG in managing gastrointestinal diseases. However, further investigations are necessary to validate its therapeutic benefits, elucidate the underlying mechanisms, and assess its potential toxicity.

KEGG pathway enrichment analysis identified pathways related to cancer, chemical carcinogenesis, metabolic regulation, and xenobiotic response. Overall, these findings provide preliminary insights into the population-specific genomic characteristics of OSCC in this regional cohort and highlight the need for larger validation studies to determine the biological significance and reproducibility of these findings.

The review also highlights advances in drug delivery strategies, such as nanoformulations, that are designed to improve curcumin's bioavailability and therapeutic efficacy. By critically integrating current evidence, this review highlights both the promise and the challenges associated with curcumin-based monotherapy in HNC, emphasizing the need for more robust and clinically relevant studies to support future translation.

Prevention should therefore integrate exposure control, biopsy-based diagnosis, local treatment when indicated, long-term surveillance, and trial-based precision strategies according to lesion risk, intervention window, and safety profile. This review supports a shift from lesion-centered management toward risk-adapted precision prevention in inflammation-driven oral carcinogenesis.

The presence of strong trans-heterodimer effects in this disease illustrates the need to analyse HLA-DQ-associated diseases with methods beyond simple conditioning. The invariance to DQA1 polymorphisms in LP may facilitate the identification of potential pathological epitopes.

SP1-induced NAT10 upregulation promoted OSCC advancement through ac4C-mediated SLC1A5 modification, providing new insights into OSCC treatment. The online version contains supplementary material available at 10.1007/s10616-026-01010-x.

P2, N=216, Active, not recruiting, EpicentRx, Inc. | Recruiting --> Active, not recruiting | Trial completion date: Oct 2025 --> Oct 2027 | Trial primary completion date: Jul 2025 --> Jul 2027

Our findings suggest that, in Bangladeshi patients, specific dietary and lifestyle factors, rather than HPV infection or TERT promoter mutations, contribute significantly to OSCC development. Targeted public health strategies emphasizing nutritional awareness and cessation of betel-quid use are recommended.

Genetic factors, particularly ALDH2 polymorphisms, together with environmental exposures and microbial dysbiosis, may further influence aldehyde burden and oral disease susceptibility. Although current evidence supports the biological relevance of salivary ALDHs, their utility as clinical biomarkers or therapeutic targets remains investigational and requires further mechanistic and clinical validation.