Oral Cancer

The strong concordance between immunohistochemical and transcriptomic profiles-with the exception of DLG7-highlights the disruption of cell polarity as an early and central molecular event in oral carcinogenesis. Collectively, the polarity regulators PAR3, SCRIBBLE, and DLG7 emerge as promising biomarkers for early malignant transformation in oral potentially malignant disorders (OPMDs) and as potential modulators of tumor initiation, progression, and invasive behavior.

The core action targets of curcumin are MMP9, TP53, MYC and TNF, among others, and its key signaling pathways are PI3K/AKT, tumor and other signals, and so on, so that multi-component, multi-targets, and multi-pathways exert its therapeutic effects on OSF. By elucidating the multi-target mechanism of action of curcumin, our study offers a new theoretical basis for the clinical therapy strategy of OSF.

P=N/A, N=2, Completed, Alpha Tau Medical LTD. | Recruiting --> Completed | N=39 --> 2 | Trial primary completion date: Jan 2025 --> Dec 2025

P=N/A, N=100, Not yet recruiting, Hospices Civils de Lyon

This interplay observed between cancer cells, neurons, and glial cells suggests a potential mechanism through which tumor-associated nerves might influence cancer stemness via metabolic reprogramming. This highlights a possible direction for anticancer therapy that warrants further investigation.

By integrating insights from molecular biology, pharmacology, and clinical studies, this work underscores the therapeutic potential of targeting TRP channels as a novel approach in oral cancer management. Future research directions include delineating channel-protein interactions and developing selective TRP inhibitors to improve treatment outcomes.

In summary, our study identified SOX4, N-cadherin, TWIST1, E-cadherin, lymph node metastasis, and clinical staging as independent factors influencing the prognosis of OSCC. SOX4 promotes EMT, thereby influencing the progression and prognosis of OSCC.

P=N/A, N=30, Recruiting, Alpha Tau Medical LTD. | Trial primary completion date: Jun 2025 --> Jun 2026

The reciprocal regulation between TNF-α and autophagy may contribute to tumor progression in OSCC.

Detailed, systematic histopathological and immunohistochemical (IHC) assessment for validation and confirmatory diagnosis is imperative. An added evaluation for tumour outcome with affirmative markers (DOG1), proliferative markers (Ki67), add value in diagnosis and prognostication of this tumour.

This study demonstrates that saliva from OSCC patients promotes tumor progression in vivo through a multifactorial mechanism involving inflammation, stromal remodeling, and metabolic rewiring. These findings highlight the tumor-promoting potential of salivary and microbial components, suggesting new avenues for diagnostic and therapeutic strategies targeting the oral microenvironment in OSCC.

Functional studies reveal that HOMER3 overexpression enhances ECM stiffness, type I collagen deposition, and Aβ accumulation in the tumor stroma, leading to tumor growth and aggressiveness, while HOMER3 knockdown reduces ECM stiffness, disrupts collagen composition, and increases sensitivity to docetaxel. These findings establish HOMER3 as a pivotal regulator of OSCC malignancy and chemoresistance, providing novel insights into its role in orchestrating the tumor microenvironment and identifying it as a promising therapeutic target for OSCC.