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    GENE:

    OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like)

    i
    Other names: OPCML, Opioid Binding Protein/Cell Adhesion Molecule Like, IGLON1, OBCAM, IgLON Family Member 1, OPCM, Opioid-Binding Protein/Cell Adhesion Molecule, Opioid Binding Protein/Cell Adhesion Molecule-Like Preprotein, Opioid-Binding Cell Adhesion Molecule
    1m
    Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells. (PubMed, Front Oncol)
    Functional validation used a single OPCML small interfering RNA (siRNA) with a non-targeting siRNA control (siNC) in U87 and U251 cells with Transwell invasion, wound healing, colony formation, CCK-8 proliferation, and Western blotting for p-AKT and p-mTOR, with LY294002 rescue...Loss of OPCML aligns with proliferative programs and a GBM-specific immune pattern. These data nominate OPCML as a prognostic marker and a surface-level modulator that could be leveraged alongside RTK/PI3K axis inhibitors in GBM.
    Journal
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    OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like)
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    IDH wild-type
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    LY294002