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DRUG:

OMO-103

i
Other names: OMO-103, Omomyc cell-penetrating peptide, OMO103
Company:
Peptomyc
Drug class:
MYC inhibitor
10d
Phase classification • Enrollment change • Metastases
|
gemcitabine • albumin-bound paclitaxel • OMO-103
7ms
MYCure: Phase 1/2 Study to Evaluate Safety, PK and Efficacy of the MYC-Inhibitor OMO-103 in Solid Tumours (clinicaltrials.gov)
P1/2, N=22, Terminated, Peptomyc S.L. | Active, not recruiting --> Terminated; Phase 1completed; sponsor decided to change strategy to a combination study
Trial termination • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • RAS mutation
|
OMO-103
over1year
Progress in the development of a clinically viable MYC inhibitor (EACR 2023)
An Omomyc-based mini-protein therapeutic developed by Peptomyc S.L. – OMO-103 – has recently successfully completed a Phase 1 clinical study, demonstrating safety and clear signs of target engagement...ConclusionMYC inhibition is finally progressing through clinical trials and it is revealing new aspects of MYC biology, including in the context of immune modulation. The pleiotropic role of MYC in drug resistance and survival suggests that MYC inhibition could be useful to increase the efficacy of – and prevent resistance to – standard-of-care therapies.
Clinical • PARP Biomarker
|
KRAS (KRAS proto-oncogene GTPase)
|
OMO-103
2years
MYCure: Phase 1/2 Study to Evaluate Safety, PK and Efficacy of the MYC-Inhibitor OMO-103 in Solid Tumours (clinicaltrials.gov)
P1/2, N=22, Active, not recruiting, Peptomyc S.L. | Recruiting --> Active, not recruiting | N=74 --> 22
Enrollment closed • Enrollment change • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • RAS mutation
|
OMO-103
over3years
Clinical • Enrollment open
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation
|
OMO-103
over3years
Clinical • New P1/2 trial
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation
|
OMO-103