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    BIOMARKER:

    OGT-L

    i
    Other names: OGT, O-linked N-acetylglucosamine (GlcNAc) transferase, O-linked N-acetylglucosamine transferase 110 KDa subunit, Uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase, O-GlcNAc transferase P110 Subunit, HINCUT-1, HRNT1, MRX106, EC 2.4.1, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 KDa subunit
    Entrez ID:
    8473
    Related biomarkers:
    Expression
    Associations

    News

    Trials
    3years
    Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. (PubMed, Int J Mol Sci)
    Bioinformatics analyses suggested that high BCL2L1 (encoded Bcl-xL) and low BAX were, in part, associated with poor prognosis of MCL patients, e.g., when combined with low OGT, which regulates cellular O-GlcNAcylation. Our findings support recent strategies in small molecule drug discovery co-targeting antiapoptotic Bcl-2 family proteins using BH3 mimetics and Bax using Bax activators to overcome cancer drug resistance.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1)
    |
    OGT-L
    |
    bortezomib
    4years
    Comparative O-GlcNAc Proteomic Analysis Reveals a Role of O-GlcNAcylated SAM68 in Lung Cancer Aggressiveness. (PubMed, Cancers (Basel))
    Analysis of clinical specimens found that high SAM68 expression was associated with late cancer stages, and patients with high-OGT/high-SAM68 expression in their tumors had poorer overall survival compared to those with low-OGT/low-SAM68 expression. Our study revealed an invasiveness-associated O-GlcNAc proteome profile and connected O-GlcNAcylated SAM68 to lung cancer aggressiveness.
    Journal
    |
    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)
    |
    OGT-L