OGG1 (8-Oxoguanine DNA glycosylase)

Compared to normal tissue an increased expression of NOX4, OGG1, MSH2/MSH6 proteins and phospho-Smad3 was found in RAI Refractory BRAFV600E mutated tumors. Collectively, our findings reveal a mechanistic basis for NOX4's role in thyroid dedifferentiation.

Selenoh and Sephs2 protein levels were increased by Se intake (P < 0.05), but not by AFB1 exposure. Conclusively, hepatic Selenoh mRNA was more sensitive to short-term, low AFB1 exposure than its protein and showed a positive response to dietary Se intake in mice, emphasizing its potential as a valuable biomarker in assessing the Se-AFB1 interaction.

In summary, the results of this study using multiple approaches provide new mechanistic insight into the micro- and nanoplastic-induced and oxidative stress-dependent cytotoxicity in MCF-7 cells. The novel and mechanistic findings of this study will have a significant impact on our understanding of the adverse effects of micro- and nanoplastics on human health.

PARP1 and MnSOD were upregulated, but not OGG1, which indicates GRE's selective action. Our findings confirm its genoprotective effects against hydroxyurea-induced DNA damage in peripheral blood mononuclear cells, indicate a complex mechanism of action, and call for further research of this promising compound against secondary genotoxic effects of hydroxyurea.

PDHA1, OGG1, and OPA1 were identified as potential prognostic markers for pediatric AML, providing valuable insights for the development of targeted therapeutic strategies. However, further validation in larger and more diverse clinical cohorts is still required to confirm its clinical applicability.

Blood samples were collected, and gene polymorphisms were identified using PCR-RFLP technique. Our study results revealed a statistically significant association between gene polymorphisms OGG1-Ser326Cys (p = 0.008), XRCC1-Arg194Trp (p = 0.009), XRCC1-Arg399Gln (p < 0.001), APEX1-Asp148Glu (p < 0.001) and the occurrence of leukoplakia, OSMF and OSCC.

HSYC improves POI by upregulating OGG1 expression, mitigating mtDNA oxidative damage, and inhibiting granulosa cell pyroptosis.

OGG1 presents a compelling target for small-molecule modulation with potential therapeutic applications in cancer, inflammatory disorders, and age-related diseases. Finally, we discuss how ubiquitination and the circadian rhythm impact overall OGG1 abundance and consider their implications for therapeutic strategies.

We propose that OGG1 can repair damaged DNA, while in certain diseases, OGG1 promotes transcription and exacerbates disease progression. This review discusses the mechanisms of action of OGG1 and proposes it as an emerging therapeutic target for curing the aforementioned diseases.

However, comprehensive reviews detailing OGG1's mechanistic roles in reproductive diseases remain scarce. This review aims to synthesize current knowledge primarily on non-canonical functions of OGG1, with a focus on its potential involvement in disorders such as endometriosis, polycystic ovary syndrome, uterine fibroids, and malignancies, and to highlight its promise as a therapeutic target.

Targeting UNG alongside DNA-damaging therapies could disrupt cancer progression. Further studies on BER genes may support personalized treatment approaches in prostate cancer.

Despite these promising findings, the small sample sizes and short intervention durations limit statistical power and generalisability. Yoga shows potential as a complementary therapy for managing inflammation and age-related conditions, but larger, longer-term RCTs with standardised protocols are essential to substantiate its therapeutic value and elucidate its mechanisms.