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    GENE:

    OGFRP1 (Opioid Growth Factor Receptor Pseudogene 1)

    i
    Other names: OGFRP1, Opioid Growth Factor Receptor Pseudogene 1
    Associations

    News

    Trials
    11ms
    Construction and validation of a prognostic model of lncRNAs associated with RNA methylation in lung adenocarcinoma. (PubMed, Transl Cancer Res)
    Finally, the IC50 of 11 drugs had differences between high- and low-risk group, and only three of the drug's target genes (ERBB4, CASP8, and CD86) were differentially expressed. In conclusion, a prognostic model based on six feature lncRNAs (NFYC-AS1, OGFRP1, MIR4435-2HG, TDRKH-AS1, DANCR, and TMPO-AS1) was constructed by bioinformatics analysis, which might provide a new insight into the evaluation and treatment of LUAD.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • CASP8 (Caspase 8) • CD86 (CD86 Molecule) • DANCR (Differentiation Antagonizing Non-Protein Coding RNA) • MIR4435-2HG (MIR4435-2 Host Gene) • TMPO-AS1 (TMPO Antisense RNA 1) • OGFRP1 (Opioid Growth Factor Receptor Pseudogene 1)
    1year
    Construction and Validation of A Prognostic Model for Lung Adenocarcinoma Based on Ferroptosis-related Genes (PubMed, Zhongguo Fei Ai Za Zhi)
    This study successfully established a LUAD risk scoring model composed of 12 ferroptosis-related genes. In the future, this model is expected to be used in conjunction with the tumor-node-metastasis (TNM) staging system for prognostic predictions in LUAD patients.
    Journal
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    LDHA (Lactate dehydrogenase A) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • KRT6A (Keratin 6A) • MIR31HG (MIR31 Host Gene) • TRIM6 (Tripartite Motif Containing 6) • OGFRP1 (Opioid Growth Factor Receptor Pseudogene 1)
    over1year
    Integrating Bioinformatics and Experimental Validation to Identify Mitochondrial Permeability Transition-Driven Necrosis-Related lncRNAs that can Serve as Prognostic Biomarkers and Therapeutic Targets in Endometrial Carcinoma. (PubMed, Reprod Sci)
    Meanwhile, the results demonstrated that OGFRP1 plays a carcinogenic role by affecting mitochondrial membrane permeability in EC. Therefore, the risk model constructed by nine MRLs could be used to predict the clinical outcomes and therapeutic responses in patients with EC effectively.
    Journal • IO biomarker
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    OGFRP1 (Opioid Growth Factor Receptor Pseudogene 1)
    over2years
    Construction of RNA Methylation Modification-immune-related lncRNA Molecular Subtypes and Prognostic Scoring System in Lung Adenocarcinoma. (PubMed, Curr Med Chem)
    The RMM-I molecular subtype constituted the novel molecular characteristic subtype of LUAD, which complemented the existing pathological typing. More refined and accurate molecular subtypes provide help to reveal the mechanism of LUAD development. In addition, the RMM-I score offers a reliable tool for accurate prognosis of LUAD.
    Journal • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • DLGAP1-AS2 (DLGAP1 Antisense RNA 2) • LINC01116 (Long Intergenic Non-Protein Coding RNA 1116) • CRNDE (Colorectal Neoplasia Differentially Expressed) • MIR210HG (MIR210 Host Gene) • OGFRP1 (Opioid Growth Factor Receptor Pseudogene 1)
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    CTLA4 expression
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    cisplatin • paclitaxel • docetaxel • vinorelbine tartrate