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    BIOMARKER:

    OASL overexpression

    i
    Other names: OASL, 59 KDa 2'-5'-Oligoadenylate Synthase-Like Protein, 2’-5'-Oligoadenylate Synthase-Like Protein. Thyroid Receptor-Interacting Protein 14, 2’-5'-OAS-Related Protein, TR-Interacting Protein 14, 2’-5’-OAS-RP, P59 OASL, TRIP-14, OASL1, 2’-5'-Oligoadenylate Synthetase-Like, OASLd
    Entrez ID:
    8638
    almost3years
    OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway. (PubMed, FASEB J)
    The mTOR inhibitor, rapamycin, markedly reversed the effect of OASL overexpression on STAD cells. Additionally, OASL promoted tumor formation and increased tumor weight and volume in vivo. In conclusion, OASL knockdown suppressed the proliferation, migration, invasion, and tumor formation of STAD cells by inhibiting the mTOR signaling pathway.
    Journal
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    RPS6KB1 (Ribosomal Protein S6 Kinase B1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • OASL (2'-5'-Oligoadenylate Synthetase Like)
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    OASL overexpression
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    sirolimus