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    BIOMARKER:

    NXF1 expression

    i
    Other names: NXF1, Nuclear RNA Export Factor 1, TAP, Tip Associating Protein, MRNA Export Factor TAP, Tip-Associated Protein, Tip-Associating Protein, DKFZp667O0311, MEX67, Mex67
    Entrez ID:
    10482
    over1year
    Interaction of CDK12 with NXF1 is a new node for the linking mechanism between transcription and transportation of mRNA. (PubMed, Biochem Biophys Res Commun)
    Importantly, the expression level of NXF1 influences sensitivity to CDK12 inhibitors, which are emerging as novel anti-cancer drug candidates. This highlights the importance of considering the relationship between mRNA transcription and transport when targeting RNA transcription in cancer therapy.
    Journal
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    CDK12 (Cyclin dependent kinase 12) • NXF1 (Nuclear RNA Export Factor 1) • SECTM1 (Secreted and transmembrane 1)
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    NXF1 expression