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    DRUG:

    NX-1607

    i
    Other names: NX-1607
    Associations

    News

    Trials
    Company:
    Nurix Therap
    Drug class:
    T-cell stimulant, CBLB expression inhibitor
    Related drugs:
    Associations

    News

    Trials
    4ms
    NX-1607-101: A Study of NX-1607 in Adults With Advanced Malignancies (clinicaltrials.gov)
    P1, N=345, Recruiting, Nurix Therapeutics, Inc. | Phase classification: P1b --> P1 | Trial completion date: Feb 2025 --> Feb 2026
    Phase classification • Trial completion date • Metastases
    |
    paclitaxel • oxaliplatin • irinotecan • NX-1607
    11ms
    NX-1607-101: A Study of NX-1607 in Adults With Advanced Malignancies (clinicaltrials.gov)
    P1b, N=363, Recruiting, Nurix Therapeutics, Inc. | N=268 --> 363
    Enrollment change • Metastases
    |
    paclitaxel • NX-1607
    almost2years
    A FIRST-IN-HUMAN PHASE 1 TRIAL OF NX-2127, A FIRST-IN-CLASS ORAL BTK DEGRADER WITH IMID-LIKE ACTIVITY, IN PATIENTS WITH RELAPSED AND REFRACTORY B-CELL MALIGNANCIES (EHA 2022)
    Immunomodulatory drugs (IMiDs, e.g., lenalidomide) are approved as monotherapy for follicular lymphoma (FL), MZL, and MCL, in combination with other therapies for diffuse large B-cell lymphoma (DLBCL) and have shown synergy with BTK-targeted therapy...NX-2127 was shown to degrade both wild-type (WT) and C481-mutated (ibrutinib-resistant) BTK protein in vitro...The primary endpoint are dose-limiting toxicities and maximum tolerated dose (Phase 1a), objective response (Phase 1b), and safety (Phase 1a and Phase 1b) of NX-1607...Conclusion Accrual is ongoing. Clinical trial information: NCT04830137.
    Clinical • P1 data
    |
    IKZF1 (IKAROS Family Zinc Finger 1) • CRBN (Cereblon) • IKZF3 (IKAROS Family Zinc Finger 3)
    |
    BTK C481S • BTK mutation • BTK C481
    |
    Imbruvica (ibrutinib) • lenalidomide • NX-2127 • NX-1607