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    GENE:

    NUSAP1 (Nucleolar and Spindle Associated Protein 1)

    i
    Other names: NUSAP1, Nucleolar And Spindle Associated Protein 1, ANKT, PRO0310p1, BM037, Q0310, SAPL, LNP, Nucleolar And Spindle-Associated Protein 1, FLJ13421, Nucleolar Protein ANKT, NUSAP, NuSAP
    28d
    NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis. (PubMed, ACS Omega)
    Mechanistically, NUSAP1 governs IP3R phosphorylation to regulate Ca2+ homeostasis, ER stress, and mitophagy, thereby modulating apoptotic signaling in EC. Our study unveils the NUSAP1-IP3R axis as a central driver of EC progression, offering novel therapeutic targets for calcium-dependent oncogenic pathways.
    Journal
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    NUSAP1 (Nucleolar and Spindle Associated Protein 1)
    1m
    Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)
    The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.
    Journal
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    TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)
    2ms
    Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development. (PubMed, Int J Genomics)
    Following that, we considered these possible genes as targets for drugs, performed docking analysis with 255 meta-drug agents, and identified the top 10 candidate drugs (adapalene, ergotamine, imatinib, dutasteride, vistusertib, risperidone, zafirlukast, irinotecan hydrochloride, drospirenone, and telmisartan). This study uniquely combines multidataset transcriptomic integration, HubG prioritization, and MD validation to propose novel biomarker-drug pairings for PCa. The findings offer promising leads for future experimental and clinical validation.
    Journal
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    BIRC5 (Baculoviral IAP repeat containing 5) • NUSAP1 (Nucleolar and Spindle Associated Protein 1)
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    imatinib • irinotecan • vistusertib (AZD2014)
    3ms
    Research Article: In Silico Identification of Potential Inhibitors Targeting NUSAP1, A Hub Gene in Hepatocellular Carcinoma. (PubMed, Crit Rev Oncog)
    Furthermore, 9753624331-0-3 is computed as the lowest solvation-free energy of -18.1300000 and found to be non-mutagenic, negative for all toxicity studies, including the Ames test, fishes, rats, mice, and daphnia. Based on the drug-likeness, ADME, and toxicity predictions, the 9753624331-0-3 presented favorable properties and hence may be considered the potential lead targeting the NUSAP1 protein.
    Review • Journal
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    NUSAP1 (Nucleolar and Spindle Associated Protein 1)
    3ms
    Prognostic value of fatty acid metabolism-related signature and integrated analysis of the immune microenvironment in multiple myeloma. (PubMed, BMC Cancer)
    We identified 37 survival-associated FMGs in MM patients, and verified the effects of CCNA2, KIF11, and NUSAP1 on the cell cycle and proliferation of MM cells. Our results also suggest that survival-associated traits based on these genes are potentially robust prognostic biomarkers for MM patients.
    Journal
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    CCNA2 (Cyclin A2) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • KIF11 (Kinesin Family Member 11)
    4ms
    NUSAP1 Recruits DAXX to Suppress HIF-Driven Triple-Negative Breast Cancer Progression. (PubMed, Adv Sci (Weinh))
    Moreover, NUSAP1 is identified as a novel HIF-repressed gene in TNBC cells, and its expression level shows a negative correlation with clinical outcomes in TNBC patients. These findings establish an HIF-NUSAP1 double-negative feedback loop in TNBC and validate TS-MAD as a potential therapeutic strategy for HIF-driven cancer.
    Journal
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    NUSAP1 (Nucleolar and Spindle Associated Protein 1) • DAXX (Death-domain associated protein) • SETDB1 (SET Domain Bifurcated Histone Lysine Methyltransferase 1)
    4ms
    Decoding Cervical Cancer Biomarkers: An Integrated Framework of Bioinformatics, Machine Learning, and Experimental Confirmation. (PubMed, Cancer Invest)
    The ML models were developed using significantly differentially expressed genes (DEGs) involved in important pathways for cervical cancer. ML prediction models are available at https://github.com/PGlab-NIPER/CC_Pred.
    Journal
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    PLK1 (Polo Like Kinase 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • MCM2 (Minichromosome maintenance complex component 2)
    6ms
    Identification of biomarkers and potential therapeutic targets of breast cancer using bioinformatics analysis. (PubMed, Medicine (Baltimore))
    The expression levels of AURKA, DTL, and RRM2 are positively correlated with NUSAP1, indicating a common regulatory relationship among these genes. Our present study demonstrated that AURKA, DTL, NUSAP1, and RRM2 are potential diagnostic and prognostic biomarkers for BRCA, and may also be potential treatment targets for clinical implication in the future.
    Journal • BRCA Biomarker
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    AURKA (Aurora kinase A) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)
    6ms
    TRIP13-induced NUSAP1 upregulation promotes CcRCC progression through EMT and PI3K/AKT/mTOR pathway. (PubMed, J Transl Med)
    TRIP13 is upregulated in ccRCC and may serve as a novel prognostic biomarker for patient survival and treatment response. Additionally, TRIP13 enhances ccRCC cell proliferation, invasion, and EMT via the PI3K/AKT/mTOR pathway, while its expression is closely linked to immune cell infiltration and immune checkpoint regulation, offering new insights for immunotherapeutic approaches in ccRCC.
    Journal • IO biomarker
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    NUSAP1 (Nucleolar and Spindle Associated Protein 1) • TRIP13 (Thyroid Hormone Receptor Interactor 13)
    8ms
    YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice. (PubMed, Nat Commun)
    Either myeloid-specific conditional knockout of YY1 or a treatment with tenapanor for decreasing the YY1-NUSAP1-HIF-1α interaction impairs subcutaneous PCa tumor formation in mouse prostate tumor models. Lastly, a first-generation tetrahedral DNA nanostructure based on the proteolysis targeting chimera technique, termed YY1-DcTAC, allows targeting and degrading YY1 in tumor-associated macrophages for inducing antitumor effects and CD8+ T cell tumor infiltration in mouse tumor models. In summary, our findings underscore the pivotal role of YY1 in the hypoxia/HIF-1α pathway in tumor-associated macrophages and support the targeting of YY1 for treating PCa.
    Preclinical • Journal
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    CD8 (cluster of differentiation 8) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • YY1 (YY1 Transcription Factor)
    8ms
    The role and therapeutic value of NUSAP1 in human cancers. (PubMed, J Transl Med)
    Furthermore, NUSAP1 may serve as a promising biomarker for cancer diagnosis and prognosis. In this review, we discuss the roles and mechanisms of NUSAP1 in human cancers.
    Review • Journal
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    NUSAP1 (Nucleolar and Spindle Associated Protein 1)
    8ms
    Research progress on NUSAP1 and its role in digestive system neoplasms. (PubMed, Front Oncol)
    This article primarily reviews the structural characteristics, functional mechanisms, and related signaling pathways of NUSAP1, focusing on exploring the functional mechanisms of NUSAP1 in digestive system neoplasms. The objective is to offer new research perspectives into the diagnosis, treatment, and prognosis evaluation of tumors.
    Review • Journal
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    NUSAP1 (Nucleolar and Spindle Associated Protein 1)