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    BIOMARKER:

    NUAK1 overexpression

    i
    Other names: NUAK1, NUAK Family Kinase 1, ARK5, KIAA0537, AMP-Activated Protein Kinase Family Member 5, NUAK Family, SNF1-Like Kinase, 1, NUAK Family SNF1-Like Kinase 1, AMPK-Related Protein Kinase 5, Omphalocele Kinase 1, OMPHK1
    Entrez ID:
    9891
    6ms
    NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma. (PubMed, Cancer Cell Int)
    These results demonstrated that NUAK1 promoted the metastasis of ESCC cells through activating JNK/c-Jun/Slug signaling, indicating NUAK1 is a promising therapeutic target for metastatic ESCC.
    Journal
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    NUAK1 (NUAK Family Kinase 1) • SNAI2 (Snail Family Transcriptional Repressor 2)
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    NUAK1 overexpression
    1year
    NUAK1 governs centrosome replication in pancreatic cancer via MYPT1/PP1β and GSK3β-dependent regulation of PLK4. (PubMed, Mol Oncol)
    We identify a previously unknown role for NUAK1 in regulating accurate centrosome duplication and show that loss of NUAK1 triggers genomic instability. The latter activity is conserved in primary fibroblasts, raising the possibility of undesirable genotoxic effects of NUAK1 inhibition.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PLK4 (Polo Like Kinase 4) • GSK3B (Glycogen Synthase Kinase 3 Beta) • NUAK1 (NUAK Family Kinase 1) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
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    NUAK1 overexpression