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    BIOMARKER:

    NR4A1 overexpression

    i
    Other names: NR4A1, Nuclear Receptor Subfamily 4 Group A Member 1, NAK-1, NGFIB, NUR77, GFRP1, TR3, N10, HMR, Nuclear Hormone Receptor NUR/77, Early Response Protein NAK1, Orphan Nuclear Receptor HMR, Orphan Nuclear Receptor TR3, Testicular Receptor 3, ST-59, Nuclear Receptor Subfamily 4, Group A, Member 1, Growth Factor-Inducible Nuclear Protein N10, Steroid Receptor TR3, TR3 Orphan Receptor, Hormone Receptor, Nur77, NP10, NAK1
    Entrez ID:
    3164
    10ms
    NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway. (PubMed, Cancer Lett)
    Moreover, we observed that NR4A1 was highly expressed in CRC tissues and was associated with a poor prognosis. In conclusion, our results suggest that NR4A1 plays a critical role in modulating necroptosis in CRC cells and provide a new therapeutic target for CRC.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1)
    |
    NR4A1 overexpression
    11ms
    Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion. (PubMed, Cancer Immunol Immunother)
    In addition, treatment with NR4A1 antagonists induced cytokine activation markers interferon γ, granzyme B and perforin mRNAs and decreased TOX, TOX2 and NFAT in TIL-derived CD8 + T cells. Thus, NR4A1 antagonists decrease NR4A1-dependent pro-oncogenic activity and PD-L1 expression in colon tumors and inhibit NR4A1-dependent T-cell exhaustion in TILs and spleen and represent a novel class of mechanism-based drugs that enhance immune surveillance in tumors.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • GZMB (Granzyme B) • NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1)
    |
    PD-L1 expression • NR4A1 overexpression