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BIOMARKER:
NR3C1 overexpression
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Other names: NR3C1, Nuclear Receptor Subfamily 3 Group C Member 1, GR, Glucocorticoid Receptor, GRL, Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor), Nuclear Receptor Subfamily 3 Group C Member 1 Variant HGR-B(54), Nuclear Receptor Subfamily 3 Group C Member 1 Variant HGR-B(77), Nuclear Receptor Subfamily 3 Group C Member 1 Variant HGR-B(93), Nuclear Receptor Subfamily 3, Group C, Member 1, Glucocorticoid Nuclear Receptor Variant 1, GCRST, GCCR, GCR
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In multivariate analysis, NR3C1 high expression was an independent prognostic factor that predicted a longer OS of DLBCL (OS, P = 0.0003). NR3C1 is considered an independent predictor of DLBCL patients and can be used as a biomarker for the prognosis of DLBCL.
9 months ago
Journal
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NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1)
Similar relationship between USP8 mutations and expression levels were observed in analysis of silent tumors that also revealed a negative correlation between GR and tumor size and higher NR3C1 expression in densely granulated tumors. Although the associations between gene/protein expression and patients clinical features are not strong, they consistently show an evident trend in which higher receptor expression corresponds to more favorable clinical characteristics.
1 year ago
Journal
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NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1)