However, the difference in age (OR = 1.10,95%Cl 0.71-1.71, p = 0.34), gender (OR = 1.26,95%Cl 0.79-2.00, p = 0.34), Lymph node metastasis (OR = 1.44,95%Cl 0.27-7.80, p = 0.67) or larger tumor size (OR = 1.56,95%Cl 0.48-5.08, p = 0.46) was not statistically significant. Upregulation of LncRNA NR2F1-AS1 was associated with poor prognosis and advanced clinicopathologic features of tumor patients.
6 months ago
Review • Journal
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NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1) • NR2F1-AS1 (NR2F1 Antisense RNA 1)
Rescue assays showed that NR2F1 knockdown or miR-642a-3p overexpression offset NR2F1-AS1 upregulation-induced inhibition on CC cell malignant phenotypes. These findings revealed that NR2F1-AS1 played a tumor suppressor role in CC by mediating the miR-642a-3p/NR2F1 axis.
over 1 year ago
Journal
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NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1)
Lnc-Nr2f1, in turn, promoted Twist2 transcription through direct binding to its genomic DNA region. Collectively, lnc-Nr2f1 was upregulated by ZEB1 and NR2F1, and promoted migration and invasion of lung adenocarcinoma cells via TWIST2 regulation.
2 years ago
Journal
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TGFB1 (Transforming Growth Factor Beta 1) • NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
These findings demonstrated that hypoxia-induced NR2F1-AS1 expression directly increased NR2F1 levels to promote PC cell proliferation, migration, and invasion by activating AKT/mTOR signaling. Together, these findings suggest that NR2F1-AS1 could be a prospective therapeutic target for PC.
2 years ago
Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit) • NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1)
Hence, NR2F1-AS1 was found to act as an oncogene in breast cancer by suppressing miR-641. We suggested that NR2F1-AS1 could be a potential biomarker for BC diagnosis and therapy.
2 years ago
Journal
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NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1)
In conclusion, NR2F1-AS1 overexpression was significantly associated with poor prognosis. NR2F1-AS1 functions as an endogenous RNA to construct a novel ceRNA network by competitively binding to miR-146a-5p/miR-877-5p, which may contribute to PDAC pathogenesis and could represent a promising diagnostic biomarker or potential novel therapeutic target in PDAC.
over 2 years ago
Journal
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CLTC (Clathrin Heavy Chain) • NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1) • PGK1 (Phosphoglycerate Kinase 1)