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    GENE:

    NPPB (Natriuretic Peptide B)

    i
    Other names: Natriuretic Peptide B, Brain Natriuretic Factor Prohormone, Natriuretic Peptide Precursor B, Gamma-Brain Natriuretic Peptide, Natriuretic Peptides B, PreproBNP, Iso-ANP, ProBNP, Brain Type Natriuretic Peptide, Natriuretic Protein, NPPB, BNP
    Associations

    News

    Trials
    5d
    Real-world Comparative Effectiveness and Safety of Jardiance in Chinese Patients With Heart Failure of Reduced Ejection Fraction (clinicaltrials.gov)
    P=N/A, N=5000, Not yet recruiting, Boehringer Ingelheim | Initiation date: Jan 2026 --> Jan 2028
    Trial initiation date • HEOR • Real-world evidence
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    NPPB (Natriuretic Peptide B)
    10d
    Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction (clinicaltrials.gov)
    P=N/A, N=3000, Not yet recruiting, Boehringer Ingelheim | Initiation date: Jan 2026 --> Jan 2028
    Trial initiation date • Real-world evidence
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    NPPB (Natriuretic Peptide B)
    12d
    Undetectable brain natriuretic peptide as a marker of ultrasound-detected hypovolemia in patients with cancer on active treatment. (PubMed, Front Cardiovasc Med)
    In addition, our study was limited by the 2-week temporal variability of BNP and IVC measurements, which may potentially introduce bias because of the dynamic fluctuation of volume status. Further studies with larger cohorts and closer temporal alignment of BNP and TTE measurements are needed to validate these findings.
    Journal
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    NPPB (Natriuretic Peptide B)
    14d
    Cardiovascular signaling proteins as predictors of the cardiac effects of doxorubicin treatment in children with acute lymphoblastic leukemia. (PubMed, Cardiooncology)
    Decreased concentrations CT-1 and NRG-1 during doxorubicin treatment may increase cardiomyocyte death. Changes in IL-6 and VEGF suggest doxorubicin-related inflammation and angiogenesis. These markers may help identify children at greatest risk of long-term adverse outcomes.
    Journal
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    NRG1 (Neuregulin 1) • IL6 (Interleukin 6) • CRP (C-reactive protein) • NPPB (Natriuretic Peptide B)
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    doxorubicin hydrochloride
    22d
    Causal Effects of Hydrophilic Bile Acids on Carfilzomib-Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study. (PubMed, Clin Pharmacol Ther)
    Gene enrichment analysis indicated pathways involving potassium channel regulation and thromboxane signaling to be implicated. This integrative metabolomic and genetic investigation supports a potential protective role of glycoursodeoxycholic acid in cardiovascular vulnerability and motivates larger, carfilzomib-specific studies to evaluate its utility for risk stratification.
    Journal
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    NPPB (Natriuretic Peptide B)
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    carfilzomib
    23d
    A multicenter clinical study on the early diagnostic value of bedside detection of soluble growth-stimulating expression gene 2 protein (sST2) in acute aortic dissection (ChiCTR2600116910)
    P=N/A, N=0, Recruiting, Guangdong Provincial People's Hospital; Guangdong Provincial People's Hospital
    New trial
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    NPPB (Natriuretic Peptide B)
    23d
    Prospective, multicenter, target value evaluation of the safety and efficacy of atrial shunt in the treatment of heart failure (ChiCTR2500112007)
    P=N/A, N=120, Completed, Union Hospital Affiliated to Tongji Medical College, Huazhong University of science and technology; Huazhong University of Science and Technology Tong
    New trial
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    NPPB (Natriuretic Peptide B)
    25d
    A Real-world Study to Compare the Effectiveness of Sacubitril/Valsartan Versus ACEi/ARB in HFrEF Patients (clinicaltrials.gov)
    P=N/A, N=1249, Completed, Novartis Pharmaceuticals
    New trial • HEOR • Real-world evidence
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    NPPB (Natriuretic Peptide B)
    1m
    AMPERE: Ablation Versus Medical Management of Atrial Fibrillation in HFpEF (clinicaltrials.gov)
    P=N/A, N=60, Active, not recruiting, Inova Health Care Services | Trial completion date: Jan 2025 --> Feb 2026 | Trial primary completion date: Jan 2025 --> Feb 2026 | Not yet recruiting --> Active, not recruiting
    Enrollment closed • Trial completion date • Trial primary completion date
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    NPPB (Natriuretic Peptide B)
    1m
    Cyclophosphamide-Induced Hemorrhagic Myocarditis. (PubMed, JACC Case Rep)
    An expedited multimodal cardiac imaging approach is warranted when this rare cardiotoxicity is suspected.
    Journal
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    NPPB (Natriuretic Peptide B)
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    cyclophosphamide
    1m
    Identification of risk factors for myocardial injury in acute ischemic stroke with diabetes mellitus: a retrospective cohort study on stroke-heart syndrome. (PubMed, Front Stroke)
    Subgroup analysis suggested that reperfusion therapy was associated with increased myocardial injury risk in various patient subgroups. CHD, insular cortex lesions, peak NT-proBNP and CRP levels, and higher stroke severity (NIHSS score) are significant risk factors for myocardial injury in AIS patients with DM.
    Retrospective data • Journal
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    CRP (C-reactive protein) • NPPB (Natriuretic Peptide B)
    2ms
    BIOFEVIP: Descriptive Study of Circulating Gene or Protein Inflammatory Biomarkers and Bioimpedance Parameters in a Population of Patients Hospitalized for Decompensated Heart Failure With Preserved or Mildly Reduced Cardiac Function (clinicaltrials.gov)
    P=N/A, N=112, Not yet recruiting, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
    New trial
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    NPPB (Natriuretic Peptide B)