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    GENE:

    NPAP1 (Nuclear Pore Associated Protein 1)

    i
    Other names: NPAP1, Nuclear Pore Associated Protein 1, C15orf2, Nuclear Pore-Associated Protein 1, Chromosome 15 Open Reading Frame 2, Protein C15orf2
    over1year
    Diagnosis of invasive encapsulated follicular variant papillary thyroid carcinoma by protein-based machine learning. (PubMed, J Pathol Transl Med)
    Additionally, we analyzed the performance of single-protein/gene receiver operating characteristic in differentiating the invasive encapsulated follicular variant of papillary thyroid carcinoma from others within The Cancer Genome Atlas projects, which yielded an AUC > 0.5. We demonstrated that integration of high-throughput proteomics with machine learning can effectively differentiate the invasive encapsulated follicular variant of papillary thyroid carcinoma from other follicular pattern thyroid tumors.
    Journal • Machine learning
    |
    NUP98 (Nucleoporin 98 And 96 Precursor 2) • NPAP1 (Nuclear Pore Associated Protein 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    almost3years
    The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms. (PubMed, Oncologist)
    Our study revealed heterogeneity of NENs, and identified novel prognostic signatures and potential therapeutic targets, which directing improvements of clinical management for NEN patients in the foreseeable future.
    Journal • Tumor mutational burden
    |
    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • HRAS (Harvey rat sarcoma viral oncogene homolog) • NOTCH1 (Notch 1) • TSC2 (TSC complex subunit 2) • NPAP1 (Nuclear Pore Associated Protein 1)
    |
    TP53 mutation • KRAS mutation • TMB-H • HRAS mutation • TSC2 mutation • MLH3 mutation