NOV-002

The research was funded by: NCCS Cancer Fund (Research) (NCCSCF-R-YR2021-JUN-SSD1), Tanoto Foundation Professorship in Medical Oncology, New Century Foundation Limited, Ling Foundation, Singapore Ministry of Health’s National Medical Research Council Research Transition Awards (TA21jun-0005 and TA20nov-0020), Large Collaborative Grant (OFLCG18May-0028), and Collaborative centre grant (TETRAD II)... Our AITL-PI identified 3 different subgroups of patients with disparate outcomes based on their presenting clinical parameters. Low risk patients had 5-year OS exceeding 80%. Gene expression profiling found unique immune and oncogenic signalling profiles in the low risk group that would allow for further dissection in future molecular analyses.

Funding National Medical Research Council Singapore Clinician Scientist Award (NMRC/CSA-INV/0027/2018, CSAINV20nov-0021), National Research Foundation Proton Competitive Research Program (NRF-CRP17-2017-05), Ministry of Education Tier 3 Academic Research Fund (MOE2016-T3-1-004), the Duke-NUS Oncology Academic Program Goh Foundation Proton Research Programme, NCCS Cancer Fund, and the Kua Hong Pak Head and Neck Cancer Research Programme...Luminal B and PCa with high angiogenesis scores had worse DMFS (HR 2.98 [0.9-10.2]; HR 6.06 [1.3-28.2], respectively) in the EA cohort. Conclusions Herein, we validated the Decipher GC for prognostication, and using a large reference population of NA PCa tumors, identified several demographic-specific transcriptomic features, which may have implications on the efficacy of new therapeutic agents in EA men with PCa.