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    BIOMARKER:

    NOTCH4 expression

    i
    Other names: NOTCH4, INT3, Neurogenic Locus Notch Homolog Protein 4, Notch Homolog 4
    Entrez ID:
    4855
    Related biomarkers:
    Expression
    Mutation
    Others
    2ms
    The lncRNA CADM2-AS1 promotes gastric cancer metastasis by binding with miR-5047 and activating NOTCH4 translation. (PubMed, Front Pharmacol)
    What's more, the relationship among lncRNA CADM2-AS1, miR-5047 and NOTCH4 was further detected and verified in metastatic GC patient tissues. LncRNA CADM2-AS1 promoted metastasis in GC by targeting the miR-5047/NOTCH4 signaling axis, which may be a potential target for GC metastasis.
    Journal
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    NOTCH4 (Notch 4) • MIR504 (MicroRNA 504)
    |
    NOTCH4 expression
    1year
    NOTCH Pathway Genes in Ovarian Cancer: Clinical Significance and Associations with Immune Cell Infiltration. (PubMed, Front Biosci (Landmark Ed))
    NOTCH pathway genes appear to play an important role in the progression of OC by regulating immune cells, endocrine resistance, Th1 and Th2 cell differentiation, and oxidative phosphorylation. JAG2 and NOTCH1 are potential biomarkers and therapeutic targets for the treatment of OC.
    Journal • Immune cell
    |
    NOTCH1 (Notch 1) • NOTCH2 (Notch 2) • DLL3 (Delta Like Canonical Notch Ligand 3) • NOTCH3 (Notch Receptor 3) • NOTCH4 (Notch 4) • HES1 (Hes Family BHLH Transcription Factor 1) • JAG1 (Jagged Canonical Notch Ligand 1) • DLL4 (Delta Like Canonical Notch Ligand 4) • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1)
    |
    NOTCH1 expression • NOTCH3 expression • NOTCH3 overexpression • NOTCH4 expression
    over1year
    The Clinical Application of Immunohistochemical Expression of Notch4 Protein in Patients with Colon Adenocarcinoma. (PubMed, Int J Mol Sci)
    The high expression of Notch4 was clearly correlated with the histological grade of the tumour (p < 0.001), PCNA immunohistochemical expression (p < 0.001), depth of invasion (p < 0.001) and angioinvasion (p < 0.001). We can conclude that high expression of Notch4 is correlated with poor prognosis of colon adenocarcinoma patients (log-rank, p < 0.001).
    Journal
    |
    NOTCH4 (Notch 4) • PCNA (Proliferating cell nuclear antigen)
    |
    NOTCH4 expression
    over1year
    Clinical significance of Notch receptors in triple negative breast cancer. (PubMed, Breast Dis)
    Our data indicated that Notch receptors play a key role in promoting TNBC and mainly, Notch2 may contribute to poor prognosis of the disease. Hence, it is implicated that Notch2 may serve as a potential biomarker and therapeutic target for TNBC.
    Journal
    |
    NOTCH1 (Notch 1) • NOTCH2 (Notch 2) • NOTCH3 (Notch Receptor 3) • NOTCH4 (Notch 4)
    |
    NOTCH1 expression • NOTCH3 expression • NOTCH4 expression
    over1year
    Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment (AACR 2023)
    Administration of clodronate liposomes to eliminate macrophages blocked the anti-tumor effects of E7011 treatment. Taken together, our data suggests that tumor endothelial Notch4 promotes TNBC growth by altering the immune landscape and increasing anti-tumor macrophage recruitment, and that blockade via the novel anti-Notch4 E7011 antibody has potential therapeutic efficacy.
    Late-breaking abstract
    |
    NOTCH1 (Notch 1) • NOTCH4 (Notch 4)
    |
    NOTCH1 expression • NOTCH4 expression
    over1year
    Expression analysis elucidates the roles of Nicastrin, Notch4, and Hes1 in prognosis and endocrine-therapy resistance in ER-positive breast cancer patients. (PubMed, Res Pharm Sci)
    Finally, the Cox regression proportional hazard test revealed that overexpression of nicastrin was an independent worse survival factor. Presumably, upregulation of the Notch pathway may be involved in tamoxifen resistance in breast cancer patients.
    Journal
    |
    ER (Estrogen receptor) • NOTCH4 (Notch 4) • HES1 (Hes Family BHLH Transcription Factor 1)
    |
    ER positive • NOTCH4 expression
    |
    tamoxifen
    over2years
    Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma. (PubMed, Int J Mol Sci)
    Exposure of SK-UT-1B and SK-LMS-1 to DAPT and MK-0752 decreased expression of HES1 and decreased uLMS cell viability in a dose- and time-dependent manner that was unique to each GSI. Our findings suggest that GSIs are potential therapeutics for uLMS, albeit with limited efficacy.
    Journal
    |
    NOTCH3 (Notch Receptor 3) • NOTCH4 (Notch 4) • HES1 (Hes Family BHLH Transcription Factor 1)
    |
    NOTCH3 expression • NOTCH4 expression
    |
    MK-0752