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BIOMARKER:

NOTCH1 expression

i
Other names: NOTCH1, TAN1
Entrez ID:
Related biomarkers:
21h
Analysis of Primary Chronic Lymphocytic Leukemia Cells' Signaling Pathways. (PubMed, Biomedicines)
In addition, miR-15a, miR-181, and miR-146 were decreased and miR-155 had increased expression in most samples. The activation of the NOTCH pathway in vitro increases the susceptibility of primary CLL cells to apoptosis despite high BCL2 expression.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • NOTCH1 (Notch 1) • IKZF1 (IKAROS Family Zinc Finger 1) • MIR155 (MicroRNA 155) • HES1 • MIR15A (MicroRNA 15a)
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BCL2 expression • NOTCH1 expression • miR-155 expression
1d
Folate induces stemness and increases oxygen consumption under glucose deprivation by notch-1 pathway activation in colorectal cancer cell. (PubMed, Mol Cell Biochem)
These results suggest that FA protects against glucose deprivation. These effects were associated with AMPK activation, a critical metabolic mediator in nutrient consumption and availability that activates the Notch-1 pathway.
Journal
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NOTCH1 (Notch 1)
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NOTCH1 expression
2d
Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway. (PubMed, Mol Cancer)
TRPM2-AS is a novel and promising biomarker for GBC angiogenesis that promotes angiogenesis by facilitating the activation of the NOTCH1 signaling pathway. Targeting TRPM2-AS opens further opportunities for future GBC treatments.
Journal
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NOTCH1 (Notch 1) • MIR146A (MicroRNA 146a) • MIR31 (MicroRNA 31) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)
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NOTCH1 expression
11d
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma. (PubMed, Leuk Lymphoma)
It can also improve the abnormal DLBCL microenvironment in which immune escape occurs, and inhibit immune escape. This study provides a new therapeutic idea for the exploration of individualized precision therapy for patients with malignant lymphoma.
Journal • PD(L)-1 Biomarker • IO biomarker
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NOTCH1 (Notch 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD4 (CD4 Molecule) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • NFATC1 (Nuclear Factor Of Activated T Cells 1)
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PD-1 expression • HAVCR2 expression • NOTCH1 expression
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Epidaza (chidamide)
16d
Impact of NOTCH1 expression in primary breast adenoid cystic carcinoma. (PubMed, J Clin Pathol)
Our study demonstrates that in patients with breast AdCC, overexpression of NOTCH1 ≥20% is associated with larger tumour size and aggressive clinical outcomes. Importantly, NOTCH1 inhibitors may have potential therapeutic effect in patients with breast AdCC.
Journal
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NOTCH1 (Notch 1) • NFIB (Nuclear Factor I B)
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NOTCH1 expression • MYB-NFIB fusion • NOTCH1 overexpression
17d
New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway. (PubMed, Front Pharmacol)
Moreover, gene expression of caspase 3, caspase 9, Notch 1, cyclin D1, NF-кB, IL-6, and VEGF was significantly more effective with PCSeNPs than similar doses of free extract. The PCSeNPs mediated their promising anti-cancerous action by enhancing apoptosis and mitigating inflammation, which manifested in promoting the total survival rate and the tumor volume decrease.
Preclinical • Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • NOTCH1 (Notch 1) • CCND1 (Cyclin D1) • IL6 (Interleukin 6) • CASP3 (Caspase 3) • CASP9 (Caspase 9)
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CCND1 expression • NOTCH1 expression
20d
Benzimidazole-oxindole hybrids as multi-kinase inhibitors targeting melanoma. (PubMed, Bioorg Chem)
Encouraged by its efficacy, it was further investigated for its antitumor activity and mechanism of action, using sorafenib as a reference standard...It also downregulated Notch1 protein expression and decreased TGF-β1 production. Molecular docking simulations suggest that 8e binds as a promising type II kinase inhibitor in the target kinases interacting with the key regions in their kinase domain.
Journal
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FGFR1 (Fibroblast growth factor receptor 1) • NOTCH1 (Notch 1) • KDR (Kinase insert domain receptor) • TGFB1 (Transforming Growth Factor Beta 1)
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BRAF V600E • BRAF V600 • BRAF wild-type • FGFR1 expression • KDR expression • NOTCH1 expression
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sorafenib
24d
Effect of Ferroptosis Inducers and Inhibitors on Cell Proliferation in Acute Leukemia. (PubMed, Anticancer Res)
Ferroptosis inducers may serve as potential candidates for novel molecular therapy against AML and T-ALL.
Journal
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • NOTCH1 (Notch 1) • GPX4 (Glutathione Peroxidase 4) • CCND3 (Cyclin D3)
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NOTCH1 mutation • MYC expression • NOTCH1 expression
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erastin • RSL3
25d
Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia. (PubMed, J Integr Neurosci)
After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.
Preclinical • Journal
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NOTCH1 (Notch 1) • HES1
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NOTCH1 expression
25d
Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain. (PubMed, In Vivo)
NOTCH1 mediates the activation of microglia in the L5-S2 spinal cord, leading to the secretion of inflammatory factors and enhanced electrical excitability of neurons, which is related to persistent and refractory chronic prostatitis-related pain.
Journal
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NOTCH1 (Notch 1) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta)
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NOTCH1 expression
1m
NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. (PubMed, Exp Mol Med)
A NOTCH-TBC1D15 inhibitor was found to inhibit NOTCH-dependent pathways and exhibited potent therapeutic effects in PDX mouse models. This unique targeting of the NOTCH-TBC1D15 interaction not only normalized the perinuclear localization of mitochondria but also promoted potent cytotoxic effects against TICs to eradicate patient-derived xenografts through NOTCH-dependent pathways.
Journal
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NOTCH1 (Notch 1) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • CDK9 (Cyclin Dependent Kinase 9) • JUN (Jun proto-oncogene)
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NOTCH1 expression
1m
Preclinical • Journal
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • HES1 • MIR19B1 (MicroRNA 19b-1)
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MYC expression • PTEN expression • NOTCH1 expression
1m
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway. (PubMed, Funct Integr Genomics)
In conclusion, miR-34c-5p was down-regulated in BAS and may inhibit fibroblast proliferation differentiation and EMT in BAS via the MDMX/p53 signaling axis. These findings expand the understanding of the role of miR-34c-5p and will help develop new treatment strategies for BAS.
Journal
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TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PI3K (Phosphoinositide 3-kinases)
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TP53 expression • NOTCH1 expression
1m
Differential Expression of NOTCH-1 and Its Molecular Targets in Response to Metronomic Followed by Conventional Therapy in a Patient with Advanced Triple-Negative Breast Cancer. (PubMed, Biomedicines)
Analysis of one patient still alive from the first group, diagnosed with mTNBC in 2019, showed a complete metabolic response (CMR) after a composite approach implicating first-line mCHT followed by second-line epirubicin and third-line nab-paclitaxel, and was chosen for subsequent molecular characterization. Additionally, we found changes in the expression of oncogenes, such as MYC and AKT, along with their respective proteins. Overall, our data suggest that a first-line treatment with mCHT followed by MTD might be effective by negatively regulating stemness traits usually associated with the emergence of drug resistance.
Journal • Metastases
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NOTCH1 (Notch 1)
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MYC expression • NOTCH1 expression
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albumin-bound paclitaxel • epirubicin
2ms
Activation of Notch1-GATA3 pathway in asthma bronchial epithelial cells induced by acute PM2.5 exposure and the potential protective role of microRNA-139-5p. (PubMed, J Asthma)
Acute PM2.5 exposure can activate Notch1-GATA3 pathway in asthma bronchial epithelial cells model, which might be involved in PM2.5-induced asthma exacerbation. miR-139-5p has a potential protective role of inhibiting PM2.5-induced asthma airway inflammation by targeting Notch1.
Journal
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NOTCH1 (Notch 1) • GATA3 (GATA binding protein 3) • MIR139 (MicroRNA 139)
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NOTCH1 expression • miR-139-5p expression
2ms
Functional Enrichment Analysis of Tumor Microenvironment-Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis. (PubMed, Bioinform Biol Insights)
Expression of NOTCH1, ID1, and LST1 genes showed a significant increase at the HCC tumor border. Targeting these genes can be considered as a useful therapeutic strategy to prevent distant metastasis in HCC patients.
Journal
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NOTCH1 (Notch 1) • ITK (IL2 Inducible T Cell Kinase)
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NOTCH1 expression
2ms
Influence of copper(I) nicotinate complex on the Notch1 signaling pathway in triple negative breast cancer cell lines. (PubMed, Sci Rep)
The co-treatment of TNBC cells with doxorubicin (Doxo) and CNC was also investigated...The observed effects of CNC may reflect the possible anti-cancer activities of CNC in both types of TNBC. However, cell type and CNC dose should be considered.
Preclinical • Journal
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NOTCH1 (Notch 1)
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NOTCH1 expression
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doxorubicin hydrochloride
2ms
FBXO8 is a novel prognostic biomarker in different molecular subtypes of breast cancer and suppresses breast cancer progression by targeting c-MYC. (PubMed, Biochim Biophys Acta Gen Subj)
These findings illuminate the novel role of FBXO8 as a prognostic and therapeutic target across different molecular subtypes of breast cancer. Finally, through the utilization of virtual screening and Molecular Dynamics simulations, we successfully identified two FDA-approved medications, Ledipasvir and Paritaprevir, that demonstrated robust binding capabilities and interactions with FBXO8.
Journal • IO biomarker
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • IL6 (Interleukin 6) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • IL10 (Interleukin 10)
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MYC expression • NOTCH1 expression • IL6 expression
2ms
Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration. (PubMed, J Orthop Surg Res)
Yougui Wan can inhibit the inflammatory response in IDD rats, reduce the degradation of extracellular matrix, reduce apoptosis in nucleus pulposus cells, and alleviate intervertebral disk degeneration. The mechanism may be related to the regulation of the Notch signaling pathway.
Preclinical • Journal
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NOTCH1 (Notch 1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • MIF (Macrophage Migration Inhibitory Factor)
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NOTCH1 expression
2ms
Analysis of Notch1 protein expression in methotrexate-associated lymphoproliferative disorders. (PubMed, J Clin Exp Hematop)
The results showed that NOTCH1 may be involved in the proliferation and tumorigenesis of B cells under the use of MTX. Further research, including genetic studies, is necessary.
Journal
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CD20 (Membrane Spanning 4-Domains A1) • NOTCH1 (Notch 1)
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CD20 positive • NOTCH1 mutation • NOTCH1 expression
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methotrexate
2ms
Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1. (PubMed, Curr Med Sci)
These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1, implying that Prox1 could be a potential therapeutic target for RB.
Journal
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NOTCH1 (Notch 1)
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NOTCH1 expression • NOTCH1 overexpression
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vincristine
2ms
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing ferroptosis. (PubMed, Toxicol Appl Pharmacol)
Intriguingly, low-dose OMP-52 M51 strongly facilitated the capacity of ferroptosis inducer erastin to trigger ferroptotic cell death, revealing that OMP-52 M51 could improve the sensitivity of ACC cells to ferroptosis. In vivo, OMP-52 M51 administration suppressed tumor growth and induced ferroptosis in the constructed ACC xenograft mouse model. Collectively, our findings demonstrated that NOTCH1 inhibition by OMP-52 M51 represses the proliferation and epithelial-mesenchymal transition (EMT) in ACCs, and promotes ferroptosis, revealing the potential therapeutical application of OMP-52 M51 in ACC.
Journal
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NOTCH1 (Notch 1) • GPX4 (Glutathione Peroxidase 4) • NICD (NOTCH1 intracellular domain)
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NOTCH1 expression
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erastin • brontictuzumab (OMP-52M51)
2ms
N6-methyladenosine reader YTHDF1 promotes stemness and therapeutic resistance in hepatocellular carcinoma by enhancing NOTCH1 expression. (PubMed, Cancer Res)
Lipid nanoparticles targeting YTHDF1 significantly enhanced the efficacy of lenvatinib and sorafenib in HCC in vivo. Taken together, YTHDF1 drives HCC stemness and drug resistance through a YTHDF1-m6A-NOTCH1 epitranscriptomic axis, and YTHDF1 is a potential therapeutic target for treating HCC.
Journal
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NOTCH1 (Notch 1) • YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1)
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NOTCH1 expression • NOTCH1 overexpression
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sorafenib • Lenvima (lenvatinib)
2ms
Dishevelled-associated antagonist of β-catenin homolog 3 (DACT3) suppresses glioma progression though Notch1 signaling pathway in β-catenin-dependent manner. (PubMed, Heliyon)
This study stands as the pioneer in examining the role of DACT3 in glioma progression and comprehensively elucidating its molecular mechanisms in glioma development. Therefore, our results suggest that DACT3 holds promise as both a prognostic factor and a potential biomarker for guiding treatment strategies in glioma patients (Graphical Abstract).
Journal
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NOTCH1 (Notch 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • NICD (NOTCH1 intracellular domain)
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NOTCH1 expression
3ms
IMMUNOPHENOTYPE OF LEUKEMIC CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH NOTCH1 AND SF3B1 GENE MUTATIONS. (PubMed, Exp Oncol)
Our data confirmed a reduced CD20 expression in CLL patients with NOTCH1 and SF3B1 mutations. In addition, an approach was proposed to identify high-risk CLL patients for prediction of such mutations: previously untreated CLL patients at advanced Binet - Rai stages (BII, CIII, CIV) with a reduced number of double-positive CD20+CD5+ cells in peripheral blood and/or low iMFI of CD20+ cells.
Journal
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TP53 (Tumor protein P53) • CD20 (Membrane Spanning 4-Domains A1) • NOTCH1 (Notch 1) • SF3B1 (Splicing Factor 3b Subunit 1) • CD5 (CD5 Molecule)
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TP53 mutation • NOTCH1 mutation • SF3B1 mutation • CD20 expression • NOTCH1 expression
3ms
Journal
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NOTCH1 (Notch 1) • CD44 (CD44 Molecule) • THY1 (Thy-1 membrane glycoprotein)
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CD44 expression • NOTCH1 expression • CD133 expression
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Lenvima (lenvatinib)
3ms
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice. (PubMed, Phytomedicine)
In summary, the regulatory effects of Rg5 on the Notch1 signaling pathway play a crucial role in modulating hepatic lipid metabolism and preventing hepatocyte apoptosis, thereby impeding the progression of NASH. These findings highlight the potential of Rg5 as a promising natural product for interventions targeting NASH.
Preclinical • Journal
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NOTCH1 (Notch 1) • TGFB1 (Transforming Growth Factor Beta 1)
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NOTCH1 expression
3ms
GRWD1 Over-Expression Promotes Gastric Cancer Progression by Activating Notch Signaling Pathway via Up-Regulation of ADAM17. (PubMed, Dig Dis Sci)
GRWD1 promotes GC progression through ADAM17-dependent Notch signaling, and GRWD1 may be a novel tumor marker and therapeutic target.
Journal
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NOTCH1 (Notch 1) • ADAM17 (ADAM Metallopeptidase Domain 17) • NICD (NOTCH1 intracellular domain)
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NOTCH1 expression
3ms
Cancer-associated fibroblasts-induced remodeling of tumor immune microenvironment via Jagged1 in glioma. (PubMed, Cell Signal)
We also found that glioma-derived Jagged1 promotes the increase of tumor-infiltrating macrophages, M2 macrophages and Foxp3 Treg cells, as well as no significance of M1 macrophages and CD8 T cells, indicating potential immunosuppression. This study opens up novel therapeutic strategies reversing CAF immunosuppression for gliomas.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • NOTCH1 (Notch 1) • CD8 (cluster of differentiation 8) • FOXP3 (Forkhead Box P3) • JAG1 (Jagged Canonical Notch Ligand 1)
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PD-L1 expression • MYC expression • NOTCH1 expression • JAG1 expression
3ms
Ectopic expression of tumor suppressive miR-181c-5p downregulates oncogenic Notch signaling in MDA-MB-231 cells. (PubMed, Pathol Res Pract)
In conclusion, present study suggests that the forced expression of tumor suppressive miR-181c-5p negatively regulates oncogenic Notch1 signaling in TNBC. Negative regulation of Notch1 signaling via miR-181c-5p mimic could be a hopeful therapeutic strategy in TNBC patient treatment.
Journal
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NOTCH1 (Notch 1) • HES1 • MIR181C (MicroRNA 181c)
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NOTCH1 expression
4ms
Blockade of Notch1 Signaling Alleviated Podocyte Injury in Lupus Nephritis Via Inhibition of NLRP3 Inflammasome Activation. (PubMed, Inflammation)
Notch1 pathway was overactivated in podocytes of LN patients and MRL/lpr mice. Blockade of Notch1 pathway reduced renal inflammation and alleviated podocyte injury via inhibition of NLRP3 inflammasome activation in LN.
Journal
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NOTCH1 (Notch 1) • WT1 (WT1 Transcription Factor) • NLRC5 (NLR Family CARD Domain Containing 5) • NICD (NOTCH1 intracellular domain) • NLRP3 (NLR Family Pyrin Domain Containing 3)
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NOTCH1 expression
4ms
Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling. (PubMed, Phytomedicine)
Bruceine D effectively weakened the "tumor-CAF-inflammation" network by inhibiting the mutual activation of Notch1-Jagged1 and NF-κB(p65) and thereby suppressed TNBC metastasis. This study first explored that Bruceine D disrupted the cross-talk between CAFs and tumor cells under TNF-α stimulation to inhibit the metastasis of TNBC, and highlighted the potential of Bruceine D as therapeutic agent for suppressing tumor metastasis.
Journal
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NOTCH1 (Notch 1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • TGFB1 (Transforming Growth Factor Beta 1) • MMP9 (Matrix metallopeptidase 9)
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NOTCH1 expression
4ms
CLL Cells within the Proliferation Centers of the Patient Lymph Nodes Are Enriched for Notch Signaling, Thus NOTCH a Viable Target for CLL Therapy (ASH 2023)
Therefore, as a next logical step we treated the MEC-1 and OSU-CLL cells in culture and primary CLL cell from patients with NOTCH inhibitor RO4929097 (RO), a γ-secretase inhibitor for 24, 48 and 72 hours in vitro...This work was partially supported by bridge funding from the American Association of Hematology awarded to Dr. Runqing Lu, who passed away during the pursuit of this study.
Clinical
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NOTCH1 (Notch 1) • BTK (Bruton Tyrosine Kinase) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • NOTCH2 (Notch 2) • IRF4 (Interferon regulatory factor 4) • NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase)
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NOTCH1 expression • IRF4 expression
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RG4733
4ms
The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus. (PubMed, Dent Res J (Isfahan))
There was no correlation between NOTCH1 expression and age, gender, tumor grade, and stage. Since the OSCC is a malignant lesion and the OLP showed the possible nature of malignancy transformation, we can consider the NOTCH1 as a biomarker for the assessment of the tumorigenesis process with a definition of a standard threshold for potentially malignant lesions and malignant OSCC tumors.
Journal
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NOTCH1 (Notch 1) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase)
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NOTCH1 expression
4ms
Optimization of a Three-Dimensional Culturing Method for Assessing the Impact of Cisplatin on Notch Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC). (PubMed, Cancers (Basel))
Combining cisplatin with a γ-secretase inhibitor (crenigacestat) increased sensitivity and induced cell death in the less sensitive cell line, while cisplatin alone was more effective in the moderately sensitive line and sensitivity decreased with the Notch inhibitor. Additionally, the Notch ligand JAG2 had additional, protective effects reducing cell death from cisplatin exposure. In summary, we observed an inverse relationship between NOTCH1 and NOTCH3 levels and cisplatin responsiveness, overall protective effects by CAFs, and a potential link between JAG2 expression with tumor cell survival.
Journal
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NOTCH1 (Notch 1) • NOTCH3 (Notch Receptor 3)
|
NOTCH1 expression
|
cisplatin • crenigacestat (LY3039478)
4ms
The aryl hydrocarbon receptor (AhR) activation mediates Benzo(a)pyrene-induced overexpression of AQP3 and Notch1 in HaCaT cells. (PubMed, Environ Mol Mutagen)
The bioinformatics analysis showed that these genes were enriched in related cancer signaling pathways. The findings suggest that AQP3 and Notch1 are upregulated by AhR activation in HaCaT cells exposed to BaP.
Journal
|
NOTCH1 (Notch 1) • AQP3 (Aquaporin 3) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1)
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NOTCH1 expression
4ms
A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma. (PubMed, Mol Cell Biol)
Thus, we have uncovered a novel mechanism by which SNAI2 and CTCF maintenance of a sub-TAD boundary promotes rather than represses NOTCH1 expression. Further, we demonstrate that SNAI2 suppression of apoptosis post-radiation is independent of SNAI2/NOTCH1 effects on self-renewal and differentiation.
Journal
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NOTCH1 (Notch 1) • SNAI2 (Snail Family Transcriptional Repressor 2)
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NOTCH1 expression • SNAI2 deletion
5ms
The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway. (PubMed, Mutat Res)
Together, our outcomes demonstrated that E2F1 fostered LUAD progression by activating MELTF via the Notch signaling activity. Hence, MELTF emerged as a feasible target for treating LUAD.
Journal
|
NOTCH1 (Notch 1) • MELTF (Melanotransferrin) • HES1 • E2F1 (E2F transcription factor 1)
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NOTCH1 expression • MELTF expression • MFI2 expression
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RG4733
5ms
Knocking down SOX2 overcomes the resistance of prostate cancer to castration via notch signaling. (PubMed, Mol Biol Rep)
We demonstrated that SOX2/Notch signaling was responsible for Enzalutamide resistance in CRPC. Targeting SOX2/Notch signaling might represent a new choice for the treatment and therapy of CRPC.
Journal
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NOTCH1 (Notch 1) • SOX2 • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1)
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NOTCH1 expression • SOX2 expression
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enzalutamide capsule
5ms
The beneficial effects of l-carnitine and infliximab in methotrexate-induced hepatotoxicity: Emphasis on Notch1/Hes-1 signaling. (PubMed, Arch Pharm (Weinheim))
The LC ameliorative effect against MTX-induced hepatotoxicity is significantly better than that of INF. Therefore, LC cotreatment may present a safe and therapeutically effective therapy in alleviating MTX-induced hepatotoxicity.
Journal
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NOTCH1 (Notch 1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • HES1 • IL1B (Interleukin 1, beta)
|
NOTCH1 expression
|
methotrexate
5ms
Uncovering NOTCH1 as a Promising Target in the Treatment of MLL-Rearranged Leukemia. (PubMed, Int J Mol Sci)
We also demonstrated that CAD204520 treatment of MLLr cells significantly reduces NOTCH1 and its target genes as well as NOTCH1 receptor expression. This was not observed with a comparable cytarabine treatment, indicating the specificity of the small molecule...In conclusion, our findings uncover the oncogenic relevance of the NOTCH1 pathway in MLLr leukemia. Its inhibition leads to specific anti-leukemic effects and paves the way for further evaluation in clinical settings.
Journal
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NOTCH1 (Notch 1) • KMT2A (Lysine Methyltransferase 2A)
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MLL rearrangement • MLL rearrangement • NOTCH1 expression
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cytarabine
5ms
High Frequency of HLA-Class II B Cell Receptor Neoantigens in IGHV Mutated-CLL (ASH 2023)
The reported low TMB in CLL does not reflect the true frequency of neoantigens, as it fails to account for BCR neoantigens. These contribute ~80% of the neoantigen pool and are predominantly presented by HLA-II. The majority of BCR neoantigens in M-CLL are within the V region, whereas in U-CLL, BCR neoantigens are largely restricted to the V(D)J recombination site.
Tumor mutational burden • IO biomarker
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TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • ATM (ATM serine/threonine kinase) • NOTCH1 (Notch 1) • SF3B1 (Splicing Factor 3b Subunit 1) • IGH (Immunoglobulin Heavy Locus) • XPO1 (Exportin 1)
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TP53 mutation • ATM mutation • TMB-L • SF3B1 mutation • IGH mutation • NOTCH1 expression • ATM expression • BCR expression • XPO1 mutation