Patients can be grouped into three clusters by the estimated time to development of cancer from precancer by acquiring additional mutations (Range: 4-10?years). Our findings provide deep molecular insights into the evolutionary processes and trajectories of oral cancer initiation and progression.

over 2 years ago

Journal

EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • HRAS (Harvey rat sarcoma viral oncogene homolog) • NOTCH1 (Notch 1) • CASP8 (Caspase 8)

TP53 mutation • EGFR amplification • NOTCH1 amplification

4years

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin. (PubMed, Nat Commun)

In an orthotopic model of skin SCC, genetic or pharmacological inhibition of NOTCH1 activity suppresses cancer/stromal cells expansion. Here we show that NOTCH1 gene amplification and increased expression in CAFs are an attractive target for stroma-focused anti-cancer intervention.

4 years ago

Clinical • Journal

NOTCH1 (Notch 1) • FOXO3 (Forkhead box O3)

NOTCH1 amplification

4years

Identification of Genomic Alterations in Sporadic Pancreatic Neurogenic Tumors. (PubMed, Pancreas)

Furthermore, exome sequencing revealed NF1del, single nucleotide variation, TP53, and ERBB3 amplification in neurofibroma, whereas genomic duplication/deletion variants and mitochondrial abnormalities were much less than that in schwannoma. In conclusion, variants in NF1 and NF2 genes, amplification of key driver genes, and somatic and mitochondrial INV variants may play important roles in the development of pancreatic schwannoma and neurofibroma.

4 years ago

Journal

TP53 (Tumor protein P53) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • NOTCH1 (Notch 1) • MUTYH (MutY homolog)

NOTCH1 amplification