noscapine (CB 3304)

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Company:

J&J

Drug class:

Tubulin inhibitor

Related drugs:

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over4years

Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway. (PubMed, Onco Targets Ther)

However, PTEN interference counteracted the effect of noscapine on mitochondrial damage and the Warburg effect in HT29/5-FU and LoVo/5-FU cells by decreasing the activation of PI3K/mTOR signaling. These results indicated that noscapine induced the apoptosis of HT29/5-FU and LoVo/5-FU human colon cancer cells by regulating mitochondria damage and the Warburg effect via PTEN, and the process is closely related to the PI3K/mTOR signaling pathway.

over 4 years ago

Journal

PTEN (Phosphatase and tensin homolog)

fluorouracil topical • noscapine (CB 3304)

almost5years

Cytotoxic, anti-proliferative and apoptotic effects of noscapine on human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines. (PubMed, Bratisl Lek Listy)

Noscapine may be a good chemotherapeutic agent for the treatment of breast cancer, especially in estrogen receptor‑negative breast cancer (Tab. 2, Fig. 7, Ref. 40).

almost 5 years ago

Preclinical • Journal

ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • BAX (BCL2-associated X protein)

docetaxel • tamoxifen • noscapine (CB 3304)