^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG CLASS:

    Norepinephrine reuptake inhibitor

    Related drugs:
    2d
    Cistanche tubulosa phenylethanol glycoside liposome ameliorates oxaliplatin-induced peripheral neuropathy by promoting RNA N6-methyladenosine modification. (PubMed, Phytomedicine)
    CPhG alleviates oxaliplatin-induced peripheral neuropathy by dual mechanisms: reducing neuroinflammation via IL-6 suppression and promoting neuronal survival and regeneration through AKT activation and m6A-dependent epitranscriptomic regulation. Compared with duloxetine, CPhG demonstrated superior neuroprotective and anti-inflammatory effects, supporting its potential as a novel therapeutic agent for OIPN.
    Journal
    |
    IL6 (Interleukin 6) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • METTL14 (Methyltransferase 14) • METTL3 (Methyltransferase Like 3)
    |
    oxaliplatin
    4d
    Efficacy and safety of bupropion hydrochloride in the treatment of stroke: a multi-center, double-blind, and randomized controlled clinical trial (ChiCTR2500105746)
    P4, N=1054, Not yet recruiting, The First Affiliated Hospital of Chongqing Medical University; Venturepharm (hainan) Co., Ltd. | Initiation date: Aug 2025 --> Jan 2026
    Trial initiation date
    4d
    Rapid Antidepressant Effects of Low-Dose Intravenous Esketamine in Patients with Chronic Pain (ChiCTR2500111749)
    P4, N=450, Not yet recruiting, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Shandong Provincial Hospital Affiliated to Shandong First Medical Univer
    New P4 trial
    7d
    The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia (clinicaltrials.gov)
    P=N/A, N=106, Recruiting, Beijing Tiantan Hospital | N=400 --> 106
    Enrollment change
    11d
    The Analgesic Efficacy and Safety of Venlafaxine in Patients With Herpes Zoster (clinicaltrials.gov)
    P=N/A, N=750, Recruiting, Beijing Tiantan Hospital
    New trial
    11d
    Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin (clinicaltrials.gov)
    P1, N=99, Completed, Children's Oncology Group | Active, not recruiting --> Completed | Trial completion date: Sep 2025 --> Dec 2025
    Trial completion • Trial completion date
    |
    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor)
    |
    MYCN amplification
    |
    cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • busulfan • Azedra (iobenguane I 131)
    12d
    Desvenlafaxine for Preventive Treatment of Frequent Episodic Tension-type Headache (clinicaltrials.gov)
    P=N/A, N=432, Active, not recruiting, Tongji Hospital
    New trial
    12d
    RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia) (clinicaltrials.gov)
    P2, N=361, Active, not recruiting, Duke University | Trial completion date: Dec 2025 --> Apr 2026 | Recruiting --> Active, not recruiting
    Enrollment closed • Trial completion date
    |
    modafinil
    12d
    Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine (clinicaltrials.gov)
    P=N/A, N=18, Terminated, Washington University School of Medicine | N=70 --> 18 | Completed --> Terminated; Due to changes in trial personnel (co-investigator and research coordinator leaving the institution).
    Enrollment change • Trial termination
    12d
    RECOVER-SLEEP: Platform Protocol (clinicaltrials.gov)
    P2, N=830, Completed, Duke University | Recruiting --> Completed
    Trial completion
    |
    modafinil
    13d
    Influence of Comorbidities on Colorectal Cancer Screening Participation and Mortality. (PubMed, Am J Med Open)
    Patient-level laboratory and cancer registry data were used to identify patients who met a specified laboratory threshold: albumin 10,000 copies or CD4 4 mg/dL, platelets 4 µmol/L, NH3 > 20, positive urine amphetamine or cocaine, serum ethanol > 80, hemoglobin A1C > 10%, and stage 3 or 4 cancer...Patients with laboratory abnormalities were less likely to have a FIT order placed and completed, and experienced higher mortality, suggesting that screening was deferred by providers. Future studies should gather provider input to understand how patient-level electronic data could be considered in the implementation of screening services.
    Journal
    |
    CD4 (CD4 Molecule)
    13d
    Combination of Duloxetine and Pregabalin to Improve Postoperative Pain (clinicaltrials.gov)
    P1, N=90, Completed, Cairo University | Not yet recruiting --> Completed | Trial completion date: Jun 2023 --> Jan 2026 | Trial primary completion date: May 2023 --> Dec 2025
    Trial completion • Trial completion date • Trial primary completion date