^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    NNMT (Nicotinamide N-Methyltransferase)

    i
    Other names: Nicotinamide N-Methyltransferase, NNMT
    Associations

    News

    Trials
    9d
    Stromal NNMT Overexpression as an Independent Prognostic Biomarker in Lung Adenocarcinoma and Breast Carcinoma. (PubMed, Carcinogenesis)
    Cox regression analysis and survival curve analysis established stromal NNMT expression as an independent prognostic factor for overall survival in LUAD and BC patients (p < 0.05). In conclusion, high stromal NNMT levels correlated with poor prognosis, establishing it as a promising biomarker for risk stratification in LUAD and BC.
    Journal
    |
    NNMT (Nicotinamide N-Methyltransferase)
    12d
    Efficacious Anti-Cancer Drugs Targeting Nicotinamide N-Methyltransferase (NNMT) in Cultured Human Oral Squamous Cell Carcinoma (OSCC). (PubMed, Pharmaceuticals (Basel))
    Thus, we deduce that the NNMT inhibitors affect mitochondrial activity indirectly via NNMT. It is concluded that NNMT is a potential drug target for oral cancer.
    Journal
    |
    NNMT (Nicotinamide N-Methyltransferase)
    13d
    Colony-stimulating factor-2 triggers NNMT-dependent myofibroblast activation in head and neck cancer. (PubMed, Oncogene)
    In drug screening assays, CSF2 blockade partially overcame resistance to TGF-β inhibition. These findings establish the CSF2/FOS/NNMT axis as a TGF-β-independent pathway driving myoCAF activation.
    Journal
    |
    CSF2 (Colony stimulating factor 2) • TGFB1 (Transforming Growth Factor Beta 1) • NNMT (Nicotinamide N-Methyltransferase)
    28d
    Detachment-Induced FAK-STAT3-NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation. (PubMed, Adv Sci (Weinh))
    Our study revealed that the upregulation of NNMT is induced by FAK-STAT3 axis, which contributes to CTCs anoikis resistance in breast cancer by activating FAO. Targeting NNMT may provide new therapeutic targets for metastatic breast cancer.
    Journal
    |
    STAT3 (Signal Transducer And Activator Of Transcription 3) • CD36 (thrombospondin receptor) • CPT1A (Carnitine Palmitoyltransferase 1A) • NNMT (Nicotinamide N-Methyltransferase)
    1m
    Pretreatment KRAS-Mutant Circulating Tumor DNA Predicts Incidence and Patterns of Recurrence in Patients Undergoing Radiofrequency Ablation for Colorectal Liver Metastases: A Prospective Analysis. (PubMed, JCO Precis Oncol)
    Pretreatment KRAS-mutant ctDNA predicts higher recurrence risk and shows an association with lung-predominant metastasis in patients with CRLM after RFA. Integrating ctDNA and KRAS profiling enhances risk stratification and supports personalized surveillance strategies.
    Journal • Circulating tumor DNA
    |
    KRAS (KRAS proto-oncogene GTPase) • NNMT (Nicotinamide N-Methyltransferase)
    |
    KRAS mutation
    2ms
    Proteogenomic characterization of cervical cancer identifies molecular subtypes predictive of clinical outcomes and subtype-specific targets. (PubMed, J Clin Invest)
    Our findings further revealed previously uncharacterized somatic copy number alterations, extrachromosomal DNA landscape, and human-HPV fusion peptides, with implications for genetic heterogeneity and therapeutic targets. This study enhances the understanding of cervical cancer through deeper proteogenomic insights, and facilitates the development of personalized therapeutic strategies to improve patient outcomes.
    Clinical data • Journal • IO biomarker
    |
    HSPB1 (Heat shock 27kDa protein 1) • TP53BP1 (Tumor Protein P53 Binding Protein 1) • NNMT (Nicotinamide N-Methyltransferase)
    2ms
    The emerging role of nicotinamide N-methyltransferase in the pathogenesis and treatment of breast cancer. (PubMed, Biochem Pharmacol)
    Future research should prioritize the development of potent NNMT inhibitors and further elucidate the role of NNMT in modulating the TME and mediating drug resistance. As a pivotal molecule linking metabolism, epigenetics, and the TME, NNMT offers promising new avenues for BC treatment.
    Review • Journal • PARP Biomarker • IO biomarker
    |
    PARP1 (Poly(ADP-Ribose) Polymerase 1) • NNMT (Nicotinamide N-Methyltransferase)
    2ms
    Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer. (PubMed, Int J Biol Sci)
    Resistance to NAMPT inhibitors, such as FK866, remains a key limitation to their clinical translation...These findings support the use of NNMT as a predictive biomarker for NAD+-targeting therapies and provide mechanistic insight into a metabolic vulnerability of the CRPC-SCL subtype. Targeting the YAP/NNMT/NAMPT axis may represent a novel strategy for treating stem-like/mesenchymal, therapy-resistant prostate cancers.
    Journal
    |
    NAMPT (Nicotinamide Phosphoribosyltransferase) • NNMT (Nicotinamide N-Methyltransferase)
    |
    daporinad (APO866)
    3ms
    Steroid-dependent metabolic rewiring reveals novel therapeutic and imaging approaches for glioblastoma. (PubMed, Sci Adv)
    Furthermore, our findings demonstrate that the dexamethasone-induced methionine-dependent nicotinamide methylation becomes detrimental for glioblastoma when combined with a methionine-restricted diet. These results show that steroids rewire methionine and nicotinamide metabolism, enabling the development of innovative PET imaging and metabolic therapies for glioblastoma.
    Journal
    |
    NNMT (Nicotinamide N-Methyltransferase)
    3ms
    Transcriptional Activity of Genes Related to the Biotransformation Process in the Development of Colorectal Cancer. (PubMed, Int J Mol Sci)
    It was stated that the AHR, EPHX1, GSTP1, and SLC25A32 did not correlate in healthy intestinal tissue whereas AHCY, ALDH1A1, NNMT, GSTM4, UGT2B17, and SLCO1B3 did not correlate in CRC. The disturbed transcriptional activity of genes related to the biotransformation process at all stages of CRC suggests that this may be the cause of its occurrence; the genes ought to be taken into account in preventive strategies and the treatment of patients.
    Journal
    |
    GSTP1 (Glutathione S-transferase pi 1) • SLCO1B3 (Solute carrier organic anion transporter family member 1B3) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) • EPHX1 (Epoxide Hydrolase 1) • NNMT (Nicotinamide N-Methyltransferase) • SLC25A3 (Solute Carrier Family 25 Member 3) • UGT2B17 (UDP Glucuronosyltransferase Family 2 Member B17) • SLC29A2 (Solute Carrier Family 29 Member 2) • SLC5A6 (Solute Carrier Family 5 Member 6)