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    GENE:

    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)

    i
    Other names: NME4, NME/NM23 Nucleoside Diphosphate Kinase 4, Nm23-H4, NDPKD, NM23H4, Non-Metastatic Cells 4, Protein Expressed In, Nucleoside Diphosphate Kinase, Mitochondrial, Nucleoside Diphosphate Kinase D, NDP Kinase, Mitochondrial, NDK, NDP Kinase D, NDPK-D, NM23D
    Associations

    News

    Trials
    15d
    Upregulation of NME4 is associated with progression and poor prognosis in clear cell renal cell carcinoma. (PubMed, Transl Androl Urol)
    Meanwhile, experimental results indicate its important role in tumorigenesis and progression. NME4 has the potential to serve as a biomarker and therapeutic target for ccRCC.
    Journal
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    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
    24d
    RNF6 activates JNK/c-JUN pathway in ovarian cancer by promoting K48-linked NME4 ubiquitination. (PubMed, Pathol Res Pract)
    RNF6 contributed to OC malignancy by destabilizing NME4 and activating the JNK cascade. This newly identified RNF6/NME4/JNK axis provides potential targets for therapeutic intervention in OC.
    Journal
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    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4) • RNF6 (Ring Finger Protein 6)
    29d
    Acetylated Pyrimidine Metabolism Genes as Prognostic Markers and Their Influence on Immune Profiles in Lung Adenocarcinoma. (PubMed, Hum Mutat)
    Functional validation experiments targeting TK1, including RNA interference followed by proliferation (CCK-8, EdU), migration (Transwell), and wound healing assays, substantiated its role in promoting tumor aggressiveness. Collectively, our findings suggest that integrating metabolic gene signatures with immunological context offers a promising framework for precision oncology in lung adenocarcinoma.
    Journal
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    TK1 (Thymidine Kinase 1) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
    8ms
    NME4: A novel metabolic-associated biomarker for prognosis prediction and immunotherapy response evaluation in clear cell renal cell carcinoma. (PubMed, Mol Immunol)
    In this study, we validated NME4's prognostic predictive capacity for ccRCC patients. Meanwhile, NME4 is expected to be a molecular marker to guide the precise application of immunotherapy in clinical practice.
    Journal • IO biomarker
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    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
    10ms
    Beyond environmental risk: Genetic insights into lung cancer susceptibility through whole exome analysis. (PubMed, Lung Cancer)
    several lines of evidence suggest that these genes are of potential clinical impact in lung cancer even though they have not been correlated with lung cancer in the OMIM database or other genetic databases. Therefore, these genes deserve further investigations: segregation analysis, enlarged cohorts and in vitro/in vivo studies could help to clarify their role in lung cancer.
    Journal
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    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • GLI3 (GLI Family Zinc Finger 3) • MITF (Melanocyte Inducing Transcription Factor) • DNAH8 (Dynein Axonemal Heavy Chain 8) • HNF1A (HNF1 Homeobox A) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4) • SERPINA3 (Serpin Family A Member 3) • TNFAIP8 (TNF Alpha Induced Protein 8) • CASP1 (Caspase 1) • VIRMA (Vir Like M6A Methyltransferase Associated)
    over1year
    Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma. (PubMed, J Immunother Cancer)
    The MPCDS provides personalized risk assessment and immunotherapy interventions for individual LUAD patients. NME4, a key gene within the MPCDS, has been identified as a novel oncogene associated with immune exclusion and may serve as a new target for LUAD intervention and immunotherapy.
    Journal • IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • CD8 (cluster of differentiation 8) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
    over1year
    Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice. (PubMed, Cell Death Dis)
    Our research indicates that NME8 protects against CP-induced testis and sperm damage. This may provide new insights into the physiological functions of the Nme family and potential targets for preserving fertility in young male cancer patients.
    Preclinical • Journal
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    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
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    cisplatin
    over1year
    NME4 suppresses NFκB2-CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma. (PubMed, Immunology)
    Mechanistically, we mapped out the NFκB2-CCL5 axis that was negatively controlled by NME4 in the murine ESCC cell line AKR. Collectively, these data demonstrated that regulation of NFκB2-CCL5 axis by NME4 prevents CD8+ T cells infiltration in ESCC.
    Journal
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    CD8 (cluster of differentiation 8) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
    2years
    PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases. (PubMed, Cancer Metastasis Rev)
    In this review, we therefore additionally discuss general aspects of class1 NME and PRUNE1 molecular structures as well as their posttranslational modifications and subcellular localization. The current knowledge on the contributions of PRUNE1 as well as NME proteins to signaling cascades is summarized with a special regard to cancer and metastasis.
    Review • Journal
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    NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4)
    2years
    Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes. (PubMed, PeerJ)
    Overall, extensive transcriptome analysis of gene alternative splicing and expression levels was performed in cells transfected with FSCN1 short-interfering RNA. Our data provide global insights into the regulatory mechanisms associated with the roles of FSCN1 and its target genes in lung cancer.
    Journal
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    KRT7 (Keratin-7) • NCOR2 (Nuclear Receptor Corepressor 2) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • RECQL5 (RecQ Like Helicase 5) • FSCN1 (Fascin Actin-Bundling Protein 1) • PDE3A (Phosphodiesterase 3A) • ACTG1 (Actin Gamma 1) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2) • WTAP (WT1 Associated Protein)