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    BIOMARKER:

    NLRP6 overexpression

    i
    Other names: NLRP6, NLR Family Pyrin Domain Containing 6, Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 6, NACHT, LRR And PYD Domains-Containing Protein 6, NACHT, Leucine Rich Repeat And PYD Containing 6, PYRIN-Containing APAF1-Like Protein 5, Angiotensin II/Vasopressin Receptor, PYPAF5, NALP6, NAVR/AVR, CLR11.4, NAVR, PAN3, AVR
    Entrez ID:
    171389
    Related biomarkers:
    Fusion
    7d
    Nlrp6 overexpression inhibits lipid synthesis to suppress proliferation of hepatocellular carcinoma cells by regulating the AMPK-Srebp1c axis (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
    Nlrp6 overexpression inhibits lipid synthesis in HCC cells by regulating the AMPK-Srebp1c axis, which might be a key pathway for suppressing HCC cell proliferation.
    Journal
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    NLRP6 (NLR Family Pyrin Domain Containing 6) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
    |
    AFP expression • NLRP6 overexpression • AMPK expression
    over1year
    Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression. (PubMed, Acta Pharm Sin B)
    Pioglitazone, a well-known clinical drug, up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction. In conclusion, this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs, and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression.
    Journal
    |
    NLRP6 (NLR Family Pyrin Domain Containing 6)
    |
    NLRP6 overexpression