^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    NLRP2 (NLR Family Pyrin Domain Containing 2)

    i
    Other names: NLRP2, NLR Family Pyrin Domain Containing 2, PYPAF2, NBS1, PAN1, CLR19.9, NALP2, Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 2, PYRIN Domain And NACHT Domain-Containing Protein 1, NACHT, Leucine Rich Repeat And PYD Containing 2, NACHT, LRR And PYD Domains-Containing Protein 2, PYRIN-Containing APAF1-Like Protein 2, Nucleotide-Binding Site Protein 1, FLJ20510, OZEMA18
    Associations

    News

    Trials
    5ms
    Extracellular Vesicle-Packaged miR-99a Reprograms Fibroblasts to Create an Inflammatory Niche that Drives Colorectal Cancer Metastasis. (PubMed, Cancer Res)
    Clinically, EV-miR-99a levels in the plasma correlated with the metastatic status of CRC patients. Together, these findings highlight the metastasis-promoting function of an inflammatory fibroblast niche induced by cancer cell-derived EVs and provide potential targets for the prediction and management of CRC metastasis.
    Journal
    |
    CDH1 (Cadherin 1) • TGFB1 (Transforming Growth Factor Beta 1) • MIR99A (MicroRNA 99a) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    8ms
    Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival. (PubMed, Discov Oncol)
    Higher mtDNA-CN in peripheral is correlated with the shorter overall survival in gastric cancer patient. Higher expression of MYO15A, OSGEP, and CDK10 is associated with shorter survival in gastric cancer patients, potentially by regulating mtDNA-CN, suggesting potential targets for future therapeutic interventions of gastric cancer.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    HER-2 amplification • HER-2 expression
    10ms
    A PANoptosis-Based Signature for Survival and Immune Predication in Glioblastoma Multiforme. (PubMed, Ann Clin Transl Neurol)
    Our data exhibit the prognostic value of PARGs in GBM and offer new insights for GBM pathogenesis and immune treatment.
    Journal
    |
    GATA3 (GATA binding protein 3) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    cisplatin • gefitinib • Zolinza (vorinostat)
    over1year
    Construction of the miRNA/Pyroptosis-Related Molecular Regulatory Axis in Abdominal Aortic Aneurysm: Evidence From Transcriptome Data Combined With Multiple Machine Learning Approaches Followed by Experiment Validation. (PubMed, J Immunol Res)
    This model may stand as a potent tool for diagnosing AAA and assessing disease severity. The identification of the cytosolic DNA sensing pathway and the hsa-miR-331-3p/TNF interaction axis may represent crucial targets for AAA treatment, offering deeper insights into its potential pathogenesis.
    Journal • Machine learning
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • MIR331 (MicroRNA 331) • NLRP3 (NLR Family Pyrin Domain Containing 3) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    over1year
    Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients. (PubMed, Curr Med Sci)
    HBO is beneficial for glioblastoma. Glioblastoma patients with these predictive indicators may prolong survival with HBO therapy. These potential therapeutic targets especially COL1A1, ADAMTS1 and PTBP3 deserve further validation.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    NF1 (Neurofibromin 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MDM4 (The mouse double minute 4) • CDK6 (Cyclin-dependent kinase 6) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CA9 (Carbonic anhydrase 9) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • PCNA (Proliferating cell nuclear antigen) • ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) • CDC42 (Cell Division Cycle 42) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • CXCR5 (C-X-C Motif Chemokine Receptor 5) • DDIT3 (DNA-damage-inducible transcript 3) • IGFBP3 (Insulin-like growth factor binding protein 3) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • BAK1 (BCL2 Antagonist/Killer 1) • CDC25A (Cell Division Cycle 25A) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MCM2 (Minichromosome maintenance complex component 2) • RHOJ (Ras Homolog Family Member J) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    TP53 expression • CXCL12 expression • CDK6 expression • CDKN1B expression • PCNA expression
    over1year
    Early divergent modulation of NLRP2's and NLRP3's inflammasome sensors vs. AIM2's one by signals from Aβ•Calcium-sensing receptor complexes in human astrocytes. (PubMed, Brain Res)
    These effects were specific, being significantly hindered by NPS2143 and inhibitors of PI3K (LY294002), AMPKα (Dorsomorphin), mTOR (Torin1), and JAK/TYK (Brepoticinib). The neatly divergent modulation of NLRP3's vs. AIM2's PRR proteins by Aβ•CaSR cues and by Bay11-7082 suggests that, when bacterial or viral DNA fragments are absent, AIM2 might play "anti-inflammasomal" or other roles in HCAs. However, Bay11-7082's no effect on NLRP2 PRR overexpression also reveals that CaSR's downstream mechanisms controlling inflammasomes' sensors are quite complex in HCAs, and hence, given AD's impact on human health, well worth further studies.
    Journal
    |
    IL6 (Interleukin 6) • IL18 (Interleukin 18) • AIM2 (Absent In Melanoma 2) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    LY294002 • Torin1 • dorsomorphin (Compound C) • Bay11-7082
    over1year
    Pyroptosis-associated genes and tumor immune response in endometrial cancer. (PubMed, Discov Oncol)
    Our findings have contributed to the advancement of a prognostic model for EC patients. NOD2 receptor-mediated pyroptosis mechanism potentially regulates tumor immunity and promotes the transformation of macrophages from the M2 phenotype to the M1 phenotype, which significantly impacts the progression of EC.
    Journal
    |
    GPX4 (Glutathione Peroxidase 4) • CASP6 (Caspase 6, apoptosis-related cysteine peptidase) • PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    GPX4 expression
    over1year
    HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis. (PubMed, Proc Natl Acad Sci U S A)
    These results suggest that these two NLR genes, which arose via gene duplication in primates, are fine-tuned by ELF3 yet have acquired divergent functions to enable proper expression levels of HLA-C in EVT, presumably through modulating the degradation kinetics of IkBα. Targeting the ELF3-NLRP2/NLRP7-HLA-C axis may hold therapeutic potential for managing pregnancy-related disorders, such as recurrent hydatidiform moles and fetal growth restriction, and thus improve placental development and pregnancy outcomes.
    Journal
    |
    TCF3 (Transcription Factor 3) • ELF3 (E74 Like ETS Transcription Factor 3) • HLA-C (Major Histocompatibility Complex, Class I, C) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    almost2years
    Prognostic Cell Death Index for Lung Adenocarcinoma: A Comprehensive Transcriptome-Based Analysis of Twelve Programmed Cell Death Pattern Genes. (PubMed, Front Biosci (Landmark Ed))
    The CDI, based on PCD genes, serves as a robust prognostic tool for LUAD, offering profound insights into tumor biology, immune response, and personalized treatment strategies. This study underscores the pivotal role of PCD mechanisms in LUAD pathogenesis and identifies potential therapeutic targets.
    Journal
    |
    CD4 (CD4 Molecule) • CD68 (CD68 Molecule) • ERO1A (Endoplasmic Reticulum Oxidoreductase 1 Alpha) • TRIM6 (Tripartite Motif Containing 6) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    2years
    The construction, validation and promotion of the nomogram prognosis prediction model of UCEC, and the experimental verification of the expression and knockdown of the key gene GPX4. (PubMed, Heliyon)
    Additionally, the web-based dynamic nomogram exhibited considerable potential for promotion. Notably, the key gene GPX4 exhibited characteristics of a potential oncogene in UCEC, as it facilitated malignant biological behavior and impeded apoptosis.
    Journal
    |
    GPX4 (Glutathione Peroxidase 4) • GSDME (Gasdermin E) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    GPX4 expression
    over2years
    Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function. (PubMed, Biochem Pharmacol)
    Likewise, carboplatin-treated cells showed decreased cell viability, suggesting that patients of TNBC with high level of NLRP2 respond well to chemotherapeutics...It suggested that NLRP2 helps p53 enter the nucleus to induce apoptosis. This study revealed a novel function of NLRP2 that modulated oncogenic and anti-oncogenic characteristics of hnRNPK, and provided a new biomarker for TNBC chemotherapy.
    Journal
    |
    TP53 (Tumor protein P53) • BAX (BCL2-associated X protein) • VIM (Vimentin) • NLRC5 (NLR Family CARD Domain Containing 5) • HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    TP53 expression • BAX expression
    |
    carboplatin