NKX2-3 (NK2 Homeobox 3)

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3ms

Assessment of apoptosis and autophagy in oral squamous cell carcinoma cell line treated with salivary exosomes. (PubMed, Odontology)

Statistical analysis was conducted using an independent-samples t-test, with significance set at p < 0.05. These findings support the potential of sExosomes to modulate tumor behavior by promoting apoptosis and inhibiting autophagy in OSCC, underscoring their promise as novel therapeutic agents in future cancer treatment strategies.

3 months ago

Preclinical • Journal

CASP3 (Caspase 3) • NKX2-3 (NK2 Homeobox 3)

7ms

Integrating single-cell RNA sequencing and spatial transcriptomics reveals the therapeutic effect of nitazoxanide in head and neck squamous cell carcinoma. (PubMed, Discov Oncol)

Our findings established that Nitazoxanide has the potential to play a role in the treatment of HNSCC. We suggested that Nitazoxanide acts on NKX2-3, PINK1, BIRC5 and CDKN2A to inhibit the development of HNSCC through regulating autophagy, and it is a promising candidate drug for HNSCC.

7 months ago

Journal

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • BIRC5 (Baculoviral IAP repeat containing 5) • IFNA1 (Interferon Alpha 1) • NKX2-3 (NK2 Homeobox 3)

7ms

Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics. (PubMed, Nat Commun)

Genetic deletion of Nkx2-3 or pharmacological blocking the transcriptional activity of NKX2-3 in TPCs with designed peptide induce tumor local vasoconstriction and decrease blood flow to mitigate tumor metastasis. These findings reveal that TPCs-regulated vasodilation and hemodynamics facilitate tumor metastasis, and provide a potential prognostic marker and therapeutic strategy for tumor metastasis.

7 months ago

Journal

NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • NKX2-3 (NK2 Homeobox 3)

9ms

Feasibility of machine learning-based modeling and prediction to assess osteosarcoma outcomes. (PubMed, Sci Rep)

Conversely, low-risk patients exhibited prolonged survival and distinct drug sensitivities. These findings underscore the potential of MLDPS to guide risk stratification, inform personalized therapeutic strategies, and improve clinical management in osteosarcoma.

9 months ago

Journal • IO biomarker

NKX2-3 (NK2 Homeobox 3)

11ms

Unraveling the intricate molecular landscape and potential biomarkers in lung adenocarcinoma through integrative epigenomic and transcriptomic profiling. (PubMed, Sci Rep)

Predominant hypomethylation of MRPs and RPs disrupted mitochondrial function, contributed to oxidative phosphorylation (OXPHOS) and metabolic reprogramming, favoring cancer cell survival. The survival analysis validated the clinical relevance of these hub genes, with high-expression cohorts exhibiting poor overall survival (OS) outcomes enlightened their relevance in LUAD pathogenesis and presented the potential for developing novel targeted therapeutic strategies.

11 months ago

Journal

FOSL1 (FOS Like 1) • RUNX3 (RUNX Family Transcription Factor 3) • NKX2-3 (NK2 Homeobox 3) • RPL22 (Ribosomal Protein L22)

almost2years

Gastric cancer prognosis: unveiling autophagy-related signatures and immune infiltrates. (PubMed, Transl Cancer Res)

The upregulation of CTSB in gastric cancer was linked to poor survival and increased immune infiltration. We conjectured that CTSB likely played a critical role in regulating immunity and autophagy in gastric cancer.

almost 2 years ago

Journal

HIF1A (Hypoxia inducible factor 1, alpha subunit) • PERK (Pancreatic EIF2-Alpha Kinase) • EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • ITGB1 (Integrin Subunit Beta 1) • NKX2-3 (NK2 Homeobox 3) • PTK6 (Protein Tyrosine Kinase 6) • SPHK1 (Sphingosine Kinase 1)

2years

Quantitative Analysis of NKX2-3 Expression in Human Colon: An Immunohistochemical Study. (PubMed, J Histochem Cytochem)

Furthermore, in most colorectal carcinoma samples, we observed a significant reduction of NKX2-3 expression. These findings indicate that the NKX2-3 transcription factor is produced by both endothelial and non-endothelial tissue constituents in the colon, and its expression changes during aging and in colorectal malignancies. (J Histochem Cytochem XX: XXX-XXX, XXXX).

2 years ago

Journal

CD34 (CD34 molecule) • NKX2-3 (NK2 Homeobox 3)

NKX2-3 expression

2years

Genomic Analyses Unveil the Pathogenesis and Inform on Therapeutic Targeting in KMT2A-PTD AML (ASH 2023)

Given the results obtained with menin inhibitors in KMT2A-rearranged and NPM1-mutated AML, our findings open an opportunity for exploiting a therapeutic vulnerability in all HOX-AML including KMT2A-PTD AML or AML with high MEN1 expression. Since HOX-AML highly express genes according to the HOX differentiation profile, stage-specific surface proteins coded by these genes would be promising targets.

2 years ago

Genomic analysis

FLT3 (Fms-related tyrosine kinase 3) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • KMT2A (Lysine Methyltransferase 2A) • TET2 (Tet Methylcytosine Dioxygenase 2) • CD276 (CD276 Molecule) • SRSF2 (Serine and arginine rich splicing factor 2) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • PML (Promyelocytic Leukemia) • CD34 (CD34 molecule) • STAG2 (Stromal Antigen 2) • CD14 (CD14 Molecule) • LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) • MEN1 (Menin 1) • CD1D (CD1d Molecule) • CD86 (CD86 Molecule) • HOXB2 (Homeobox B2) • NKX2-3 (NK2 Homeobox 3)

NPM1 mutation • TET2 mutation • KMT2A rearrangement • MLL rearrangement • SRSF2 mutation • U2AF1 mutation • STAG2 mutation • MLL mutation • MLL translocation • KMT2A expression • KMT2A-PTD • CD1D expression

over3years

Histone Acetyltransferases Are Critical Interacting Proteins in NUP98-Rearranged Acute Myeloid Leukemia (ASH 2022)

Finally, a counter screen in wildtype cells showed that many of the HAT complex genes are not essential in normal HSPCs, suggesting that lysine acetyltransferase complexes have a unique and potentially targetable role in NUP98::KDM5A FO-expressing cells. In summary, our studies detail the overlapping and distinct members of the protein interactome for multiple NUP98 FOs and demonstrate that MOZ and HBO1 complexes play an important role in the fitness of cells expressing NUP98::KDM5A.

over 3 years ago

IO biomarker • Epigenetic controller

KMT2A (Lysine Methyltransferase 2A) • NUP98 (Nucleoporin 98 And 96 Precursor 2) • NSD1 (Nuclear Receptor Binding SET Domain Protein 1) • HOXA9 (Homeobox A9) • BRD4 (Bromodomain Containing 4) • KDM5A (Lysine Demethylase 5A) • GATA3 (GATA binding protein 3) • PRRX1 (Paired Related Homeobox 1) • NKX2-3 (NK2 Homeobox 3)