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NFIB (Nuclear Factor I B)

News alerts, weekly reports and conference planners

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma. (PubMed, Head Neck)

ATR, AKT, and Notch inhibitors radiosensitize a preclinical model of ACC.

7 days ago

Preclinical • Journal

NOTCH1 (Notch 1) • NOTCH2 (Notch 2) • RAD51 (RAD51 Homolog A) • ATR (Ataxia telangiectasia and Rad3-related protein) • NFIB (Nuclear Factor I B)

13d

Molecular subtyping of small-cell lung cancer in clinical practice: Primary tumor-lymph node concordance, intratumoral heterogeneity, and genomic context in a Chinese cohort. (PubMed, Lung Cancer)

The observed discordance during regional nodal dissemination suggests that single site-dependent immunohistochemistry-based subtyping may be insufficient. Future frameworks incorporating multi-region analysis and liquid biopsy are essential to capture the dynamic evolution of SCLC and optimize personalized management for localized disease.

13 days ago

Journal

TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • RB1 (RB Transcriptional Corepressor 1) • NOTCH1 (Notch 1) • KMT2D (Lysine Methyltransferase 2D) • SLFN11 (Schlafen Family Member 11) • CREBBP (CREB binding protein) • YAP1 (Yes associated protein 1) • NFIB (Nuclear Factor I B) • POU2F3 (POU Class 2 Homeobox 3) • ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) • CASP10 (Caspase 10) • INSM1 (INSM Transcriptional Repressor 1) • NEUROD1 (Neuronal Differentiation 1)

13d

Development and validation of a highly accurate multigene gene expression biomarker to predict chemotherapy response in primary triple-negative breast cancer. (PubMed, Breast Cancer Res Treat)

Transcriptomic profiling combined with machine learning provides a promising approach for predicting NAC response in TNBC. The identified biomarkers may inform precision treatment strategies and improve clinical outcomes in this high-risk patient population.

13 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor) • NFIB (Nuclear Factor I B) • H2BC8 (H2B Clustered Histone 8) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) • EPHB3 (EPH Receptor B3) • ITGA6 (Integrin, alpha 6) • S100P (S100 calcium binding protein P) • USP1 (Ubiquitin Specific Peptidase 1)

HER-2 amplification

Phase Separation of NFIB Suppresses SLC3A2-Mediated Ferroptosis in Castration-Resistant Prostate Cancer. (PubMed, Adv Sci (Weinh))

NFIB knockout enhances erastin-induced ferroptosis, marked by elevated Fe2 +, MDA, and ROS levels...In vivo, combined NFIB suppression and ferroptosis induction significantly inhibit tumor growth and increase lipid peroxidation in CRPC xenografts. These findings uncover a critical role of NFIB phase separation and acetylation in ferroptosis regulation and suggest NFIB as a promising therapeutic target in CRPC.

1 month ago

Journal

SLC3A2 (Solute Carrier Family 3 Member 2) • NFIB (Nuclear Factor I B) • SIRT7 (Sirtuin 7)

erastin

Genomic and Transcriptomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes. (PubMed, J Dent Res)

Fluorescence in situ hybridization-based detection of 6q-loss and 14q-loss by probe ESR1-6q25 and FOS-14q24 provided a rapid and clinically feasible validation in ACC prognostic assessment. Further multicohort and multifactor analysis demonstrated the robustness and independence of the prognostic value in overall survival and metastasis-free survival of the molecular classification method.

1 month ago

Journal

ER (Estrogen receptor) • NFIB (Nuclear Factor I B) • MYBL1 (MYB Proto-Oncogene Like 1)

Beyond the Globe: Molecular Diagnostics of Optic Nerve, Orbital, and Adnexal Neoplasms. (PubMed, Transl Vis Sci Technol)

These advances underscore the growing role of molecular diagnostics in improving accuracy, guiding prognostication, and refining the classification of rare ocular tumors. As high-throughput techniques continue to mature, integration with evolving spatial and single-cell-based approaches promises to expand our understanding and further personalize diagnostic and therapeutic strategies.

1 month ago

Journal

BRAF (B-raf proto-oncogene) • FGFR1 (Fibroblast growth factor receptor 1) • NF1 (Neurofibromin 1) • HMGA2 (High mobility group AT-hook 2) • NFIB (Nuclear Factor I B) • STAT6 (Signal transducer and activator of transcription 6) • PLAG1 (PLAG1 Zinc Finger) • NAB2 (NGFI-A Binding Protein 2) • PAX3 (Paired Box 3)

A Comprehensive Adenoid Cystic Carcinoma-Derived Organoid Platform for Disease Modeling and Drug Screening Captures Interpatient Heterogeneity. (PubMed, Cells)

With an 88% success rate, the first ACC organoid platform, incorporating normal salivary gland (SG) organoids as toxicity controls, enabled high-throughput drug testing within two weeks. In conclusion, we developed an efficient culture system for ACC organoids that can preserve tumor heterogeneity and establish a reliable drug screening platform for mechanistic studies and personalized precision therapy research.

1 month ago

Journal

NFIB (Nuclear Factor I B)

2ms

NFIB suppresses cell migration, invasion and EMT of bladder cancer through the PI3K-AKT signaling pathway. (PubMed, Cytotechnology)

Taken together, this study highlighted that NFIB serves as a tumor suppressor gene in bladder cancer, and suppresses cell migration, invasion and EMT through the modulation of the PI3K-AKT signaling pathway, revealing NFIB as a potential biomarker for monitoring early metastasis of bladder cancer and a target for therapy. The online version contains supplementary material available at 10.1007/s10616-026-00900-4.

2 months ago

Journal

NFIB (Nuclear Factor I B)

3ms

A case report of misdiagnosed adenoid cystic carcinoma of the parotid gland on ultrasound: imaging-pathological correlation and diagnostic implications. (PubMed, Gland Surg)

This case highlights ACC's propensity for "benign-mimicking" sonographic features (well-defined margins, posterior enhancement, hypovascularity), contributing to misdiagnosis. It underscores that integrating elastography (for assessing stiffness), contrast-enhanced ultrasound (for evaluating washout patterns), CT/MRI (for detecting suspicious perineural spread), and molecular biomarkers (e.g., low Ki-67) is crucial to improving diagnostic accuracy and optimizing follow-up management for ACC.

3 months ago

Journal

SOX10 (SRY-Box 10) • NFIB (Nuclear Factor I B) • TP63 (Tumor protein 63)

3ms

Benign Sweat-Gland Tubular Adenoma Harboring an MYBL1::NFIB Fusion Gene. (PubMed, Am J Dermatopathol)

We report here an exceedingly rare case of a benign neoplasm diagnosed as benign tubular SG adenoma that was unexpectedly found to harbor a MYBL1::NFIB fusion gene. This case expands the spectrum of SG tumors driven by fusions of MYBL1, and challenges the specificity of MYBL1 fusions for cutaneous AdCC.

3 months ago

Journal

NFIB (Nuclear Factor I B) • MYBL1 (MYB Proto-Oncogene Like 1)

4ms

Molecular basis of NFIB-mediated regulation of oncogenic transcription. (PubMed, Nucleic Acids Res)

Mutational disruption of key DNA-contacting residues abolishes DNA binding and transcriptional activation, linking atomic-level recognition to oncogenic transcriptional regulation. Together, these findings elucidate the structural mechanism underlying NFIB function in cancer and establish a framework for therapeutic strategies targeting NFIB-driven malignancies.

4 months ago

Journal

FGFR3 (Fibroblast growth factor receptor 3) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • NFIB (Nuclear Factor I B)

4ms

Adenoid Cystic Carcinoma of Breast-A Narrative Review. (PubMed, Indian J Surg Oncol)

A balanced translocation in MYB-NFIB fusion gene appears to be fundamental in the pathogenesis. Surgery forms the mainstay treatment option followed by adjuvant radiation in high risk cases, as extrapolated from studies in salivary gland tumour.

4 months ago

Journal

NFIB (Nuclear Factor I B)