Neuroendocrine Tumor

P2, N=11, Active, not recruiting, Advanced Accelerator Applications | Trial completion date: May 2034 --> Feb 2034

P2, N=45, Active, not recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Dec 2025 --> Apr 2026

Moreover, these HM-CAR T cells demonstrated significant antitumor efficacy in vivo. This study highlights effective strategies for developing DLL3-specific VHHs and their application in CAR T therapy, which supports their clinical potential as a promising immunotherapeutic approach for cancers that express DLL3.

These findings indicate that SCG2 is a potential prognostic marker and therapeutic target for pNETs. It may be involved in disease progression by modulating the tumor immune microenvironment, suggesting a possible role in prognostic evaluation and clinical management.

P2, N=20, Recruiting, Tata Memorial Hospital

When a growth is suspected, it should be thoroughly evaluated before surgery to rule out other types of invasive gallbladder tumours. If investigations confirm a non-metastatic lesion, proceeding with a simple cholecystectomy is appropriate.

Outcomes were numerically more favorable in individuals with high SSTR uptake and in those treated with tandem therapy, but the study was not designed to compare treatment regimens. These exploratory findings should be regarded as hypothesis-generating only and do not provide evidence of comparative efficacy.

Immunohistochemistry showed diffuse positivity for CD56, chromogranin A, synaptophysin, and insulinoma-associated protein 1; a Ki-67 index of about 20%; negativity for CD5, CD117 (c-KIT), p63 (TP63), CK5/6, and CD20; and the absence of TdT/CD99-positive immature T cells, supporting a diagnosis of thymic atypical carcinoid. This case highlights the complementary value of imprint cytology and an appropriate immunohistochemical panel, in addition to frozen sections, in avoiding misclassification of tNENs as type A thymoma.

It reinforces that PPGLs may occur without classic catecholamine-related symptoms and highlights the clinical relevance of unexplained hypercobalaminemia as a laboratory finding warranting further evaluation. Persistent elevation of serum vitamin B12 levels following tumor resection suggests an incidental finding or a possible association with another, as yet unidentified, neoplastic process, emphasizing the importance of continued follow-up.

P3, N=800, Recruiting, University of Alberta | Trial completion date: Jul 2026 --> Dec 2027 | Trial primary completion date: Dec 2025 --> Dec 2027

Therapeutic options span from curative surgery to systemic therapies, including temozolomide, tyrosine kinase inhibitors, and nuclide therapy...Improve knowledge about the different Nuclear Medicine and functional imaging techniques in detecting lesions, depending on their location, secretory function and underlying genetic mutation. Discuss the multiple radiopharmaceuticals available for Scintigraphy and PET-CT, according to the paraganglioma site and mutational pattern.