NEFH (Neurofilament Heavy)

P4, N=558, Not yet recruiting, Zhejiang Provincial People's Hospital; Zhejiang Provincial People's Hospital

These findings suggest that the relationship between biochemical markers and cognitive function is complex. However, BDNF and NSP may serve as potential biomarkers for delayed memory impairment in men post-prostatectomy.

Our results indicate that blast exposure causes acute and sub-acute neuroinflammation and associated axonal injury in the cervical spinal cord. These data further suggest that inhibition of TLRs and/or COX-2 enzyme might offer protection against blast-induced injuries to the spinal cord.

This commercial cytokine assay was unable to distinguish between CVSM and eNAD/EDM based on CSF cytokine profiles in this population. Optimization of a more sensitive assay is warranted as CSF cytokine concentrations have high potential to be used as biomarkers to characterize neuroinflammation in equine neurological diseases.

P=N/A, N=30, Terminated, Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Trial completion date: May 2026 --> Dec 2024 | Recruiting --> Terminated | Trial primary completion date: May 2024 --> Dec 2024; Overlapping studies

Different concentrations (15-150 µg/mL) of AP and R were tested in SH-SY5Y cells differentiated into neurons exposed to oxaliplatin (10 µM), assessing cell viability (MTT), cytotoxicity (LDH), SOD activity, and expression of ATF-3, Ire1α, and Nf-H genes... Extracts from both aerial parts and roots of A. oleracea show promise in alleviating chemotherapy-induced neuropathy through mechanisms not solely related to spilanthol. Further studies to elucidate the contribution of phenolic components are desirable.

P2, N=73, Completed, AL-S Pharma | Active, not recruiting --> Completed

Despite the individual prognostic significance of necrosis, LVI, the presence of sarcomatoid and/or rhabdoid differentiation, ISUP, and TNM 8th edition, these factors did not influence the performance of our prognostic model. The model including the five DNA methylation markers, age at diagnosis, sex, TNM stage (8th edition), ISUP grading, and tumor size was the best performing model, thereby highlighting the potential importance of molecular markers.

Furthermore, no group differences were seen in cell densities or myelin coverage. This study validates a novel sorting method and provides a comprehensive characterization of OL-lineage gene expression, cell densities, and myelin in the human BLA.

Importantly, lower TSC2/POLDIP2 expression also predicted superior response rates to Everolimus therapy. In conclusion, our study comprehensively delineates genomic distinctions and evolutionary trajectories among renal AML subtypes, establishing TSC2, POLDIP2, NEFH, and MUC2 as prognostic biomarkers and therapeutic predictors, facilitating precision medicine in eAML management.

The four miRNAs are markers of good prognosis, could be involved in neuronal differentiation, and may be used as a therapeutic assessment tool for NB.

Reduced brain glucose metabolism in the cortex-striatum/limbic system-brainstem circuit may potentially serve as an independent prognostic factor for patients with ALS and NEFH mutation.