^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    NECTIN2 overexpression

    i
    Other names: NECTIN2 , Nectin Cell Adhesion Molecule 2, PRR2, Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B), Nectin-2, CD112, PVRL2, PVRR2, HVEB, Poliovirus Receptor-Related Protein 2, Herpes Virus Entry Mediator B, Herpesvirus Entry Mediator B, Herpesvirus Entry Protein B, Poliovirus Receptor-Like 2, CD112 Antigen, NECTIN2, HveB
    Entrez ID:
    5819
    Related biomarkers:
    Expression
    Associations

    News

    Trials
    8ms
    NECTIN2 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma. (PubMed, Respir Investig)
    High NECTIN2 expression in LUAD was found to be associated with postoperative recurrence, and was observed to play an important role in cell apoptosis and migration.
    Journal
    |
    NECTIN2 (Nectin Cell Adhesion Molecule 2)
    |
    NECTIN2 overexpression
    2years
    A Novel Antibody-Drug Conjugate Targeting Nectin-2 Suppresses Ovarian Cancer Progression in Mouse Xenograft Models. (PubMed, Int J Mol Sci)
    In addition, c12G1-DM1 showed ~91% tumor growth inhibition in mouse xenograft models transplanted with OV-90 cells. These results suggest that c12G1-DM1 could be used as a potential therapeutic agent against nectin-2-positive ovarian cancers.
    Preclinical • Journal
    |
    NECTIN2 (Nectin Cell Adhesion Molecule 2)
    |
    NECTIN2 overexpression