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    GENE:

    NCK1 (NCK Adaptor Protein 1)

    i
    Other names: NCK1, NCK Adaptor Protein 1, NCKalpha, NCK, SH2/SH3 Adaptor Protein NCK-Alpha, Cytoplasmic Protein NCK1, Nck-1, Non-Catalytic Region Of Tyrosine Kinase, Melanoma NCK Protein, NCK Tyrosine Kinase
    Associations

    News

    Trials
    4ms
    Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex. (PubMed, mBio)
    Our study reveals that Toxoplasma uses defined motifs to co-opt host signaling hubs that control cell motility. Understanding how pathogens exploit the cytoskeleton not only sheds light on host-pathogen interactions but may also reveal broader principles of cell migration relevant to immunity, cancer, and development.
    Journal
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    GRB2 (Growth Factor Receptor Bound Protein 2) • NCK1 (NCK Adaptor Protein 1)
    8ms
    The oncolytic avian reovirus p17 protein suppresses invadopodia formation via disruption of TKs5 complexes and oncogenic signaling pathways. (PubMed, Front Cell Infect Microbiol)
    ARV p17 inhibits cancer cell migration and invadopodia formation by activating the p53-PTEN pathway and suppressing essential signaling and scaffolding complexes (FAK-Src, Rab40b-PI3K-Akt, TKs5-Nck1, and TKs5-Rab40b). These findings suggest that p17 plays a crucial anti-metastatic role and may serve as a novel therapeutic agent for targeting invasive cancer cells.
    Journal • IO biomarker
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    NCK1 (NCK Adaptor Protein 1)
    10ms
    Expression and Clinical Significance of lncRNA NCK1-AS1 in Acute Myeloid Leukemia (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    High expression of NCK1-AS1 in AML indicates poor prognosis of AML patients.
    Journal
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    NCK1 (NCK Adaptor Protein 1)
    11ms
    Osthole mitigates the myofibroblast properties in oral submucous fibrosis by suppressing the TGF-β/smad2 signaling pathway and NCK-AS1 expression. (PubMed, J Dent Sci)
    Moreover, the administration of osthole downregulated the expression of NCK1-AS1 in fBMFs, which was proven to mediate the anti-fibrosis property of osthole. Our results indicate that osthole may be a promising compound to inhibit the progression of OSF.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • NCK1 (NCK Adaptor Protein 1)
    over1year
    The Oncolytic Avian Reovirus p17 Protein Inhibits Invadopodia Formation in Murine Melanoma Cancer Cells by Suppressing the FAK/Src Pathway and the Formation of theTKs5/NCK1 Complex. (PubMed, Viruses)
    Coexpression of TKs5 and Rab40b in B16-F10 cancer cells reversed p17-modulated suppression of the formation of invadopodia. This work provides new insights into p17-modulated suppression of invadopodia formation by activating the p53/PTEN pathway, suppressing the FAK/Src pathway, and inhibiting the formation of the TKs5/NCK1 complex.
    Preclinical • Journal • Oncolytic virus
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    MMP9 (Matrix metallopeptidase 9) • NCK1 (NCK Adaptor Protein 1)
    over2years
    Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p. (PubMed, Cancer Biomark)
    LINC00885 is expressed at a high level in TNBC. LINC00885 promoted proliferation and migration by regulating the miR-654-3p/NCK1 axis in TNBC cell lines. Possibly, LINC00885 can be served as a potential therapeutic target for TNBC.
    Journal
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    NCK1 (NCK Adaptor Protein 1)