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GENE:

NCBP1 (Nuclear Cap Binding Protein Subunit 1)

News alerts, weekly reports and conference planners

5ms

Integrated miRNA-mRNA Analyses of Triple-Negative Breast Cancer in Black and White Patients with or Without Obesity. (PubMed, Int J Mol Sci)

Pathway enrichment analysis highlighted KRAS, ESR1, ESR2, RAB10, TNRC6C, and NCAN as the most commonly differentially expressed in EA, whereas ERBB4, PLCB1, and SERPINE1 were most frequently in AA. These findings highlight the importance of considering race-specific miRNA-mRNA signatures in understanding TNBC in the context of obesity, offering insights into biomarker-driven patient stratification for targeted therapeutic strategies.

5 months ago

Journal

KRAS (KRAS proto-oncogene GTPase) • ER (Estrogen receptor) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • SERPINE1 (Serpin Family E Member 1) • MIR143 (MicroRNA 143) • MIR424 (MicroRNA 424) • CDC25B (Cell Division Cycle 25B) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR181B1 (MicroRNA 181b-1) • MIR195 (MicroRNA 195) • MIR204 (MicroRNA 204) • MIR30A (MicroRNA 30a) • NCBP1 (Nuclear Cap Binding Protein Subunit 1) • RAB10 (RAB10, Member RAS Oncogene Family)

8ms

Cellular imbalance of specific RNA binding proteins associates with harmful R-loops. (PubMed, PLoS Genet)

Our results indicate that changes in the availability of different RBPs or RNAs, causes R-loop-mediated DNA damage in the cell. These results may help to understand the mechanism that promotes cancer, as several RBPs are overexpressed in different types of tumors.

8 months ago

Journal

NCBP1 (Nuclear Cap Binding Protein Subunit 1)

10ms

Proteomics analysis explored the changes in the tumor microenvironment of CT26 tumor-bearing mice after microwave ablation. (PubMed, J Cancer Res Ther)

MWA significantly induced protein alterations in TME, with NCBP1 and CDC5L standing out as promising candidate targets for tumor treatment.

10 months ago

Preclinical • Journal

NCBP1 (Nuclear Cap Binding Protein Subunit 1)

11ms

Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development. (PubMed, Open Med (Wars))

The study supports the potential of METTL3 as a prognostic biomarker in CRC and highlights its involvement in immune modulation and cancer progression. These findings lay the groundwork for future studies aimed at developing targeted therapies and improving patient outcomes.

11 months ago

Journal

METTL14 (Methyltransferase 14) • METTL3 (Methyltransferase Like 3) • NCBP1 (Nuclear Cap Binding Protein Subunit 1) • WTAP (WT1 Associated Protein) • RBM15 (RNA Binding Motif Protein 15) • VIRMA (Vir Like M6A Methyltransferase Associated) • ZC3H13 (Zinc Finger CCCH-Type Containing 13)

1year

Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay. (PubMed, Commun Biol)

Moreover, knockdown of UPF1 in proliferating WI-38 cells induces senescence, as evidenced by increased senescence-associated β-galactosidase activity, alterations in senescence-associated molecular markers, increased endogenous γ-H2AX levels, and reduced cell proliferation. These findings suggest that the decline in UPF1 levels during cellular senescence accelerates the senescent phenotype by impairing NMD activity and the consequent accumulation of abnormal mRNA.

1 year ago

Journal

NCBP1 (Nuclear Cap Binding Protein Subunit 1) • UPF1 (UPF1 RNA Helicase And ATPase)

1year

The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases. (PubMed, Cancer Cell Int)

METTL17 may serve as a novel prognostic marker and therapeutic target for human tumors, offering a theoretical foundation for formulating more effective and tailored clinical treatment options for cancers, particularly HCC.

1 year ago

Journal

NCBP1 (Nuclear Cap Binding Protein Subunit 1) • LRPPRC (Leucine Rich Pentatricopeptide Repeat Containing)

over1year

IGF2BP3/NCBP1 complex inhibits renal tubular senescence through regulation of CDK6 mRNA stability. (PubMed, Transl Res)

Clinical data also suggests an age-related decrease in IGF2BP3 and CDK6 levels in renal tissue or serum samples from patients. These findings suggest that IGF2BP3/CDK6 may be a promising target in cisplatin-induced tubular senescence and renal failure.

over 1 year ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDK6 (Cyclin-dependent kinase 6) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • NCBP1 (Nuclear Cap Binding Protein Subunit 1)

cisplatin

2years

PABPN1 functions as a predictive biomarker in colorectal carcinoma. (PubMed, Mol Biol Rep)

In summary, PABPN1 might become a novel biomarker and correlate with tumor immunity in CRC.

2 years ago

Journal

IL10 (Interleukin 10) • CCL2 (Chemokine (C-C motif) ligand 2) • CSF1R (Colony stimulating factor 1 receptor) • RECQL4( RecQ Like Helicase 4) • NCBP1 (Nuclear Cap Binding Protein Subunit 1) • PABPC1 (Poly(A) Binding Protein Cytoplasmic 1)

2years

Identification and validation of N -methylguanosine-associated gene NCBP1 as prognostic and immune-associated biomarkers in breast cancer patients. (PubMed, J Cell Mol Med)

Therefore, m7G RNA regulators are crucial participants in BC and four-gene mRNA levels are important predictors of prognosis. NCBP1 plays a critical target of m7G mechanism in BC.

2 years ago

Journal

NCBP1 (Nuclear Cap Binding Protein Subunit 1) • WDR4 (WD Repeat Domain 4)

over2years

NCBP1 enhanced proliferation of DLBCL cells via METTL3-mediated m6A modification of c-Myc. (PubMed, Sci Rep)

Mechanistically, the expression of c-MYC is regulated by NCBP1-enhanced METTL3, and the NCBP1/METTL3/mA/c-MYC axis is important for DLBCL progression. We identified a new pathway for DLBCL progression and suggest innovative ideas for molecular targeted therapy of DLBCL.

over 2 years ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • METTL3 (Methyltransferase Like 3) • NCBP1 (Nuclear Cap Binding Protein Subunit 1)

MYC expression

almost3years

Genes whose expressions in the primary lung squamous cell carcinoma are able to accurately predict the progression of metastasis through lymphatic system, inferred from a bioinformatics analyses. (PubMed, Sci Rep)

Finally, CDK1, PLK1, PCNA, ZWINT and NDC80 identified as hub genes for underlying molecular mechanisms of lung squamous cell carcinoma and lymphatic metastasis. Our study highlights new target genes according to their relation to lymph node metastasis, whose expressions in the primary lung squamous cell carcinoma are able to accurately assess the presence of lymphatic metastasis.

almost 3 years ago

Journal

PLK1 (Polo Like Kinase 1) • PCNA (Proliferating cell nuclear antigen) • CDK1 (Cyclin-dependent kinase 1) • NCBP1 (Nuclear Cap Binding Protein Subunit 1)

almost3years

N7-methylguanosine regulatory genes well represented by METTL1 define vastly different prognostic, immune and therapy landscapes in adrenocortical carcinoma. (PubMed, Am J Cancer Res)

m7G risk score was a potential biomarker for predicting the efficacy of ICBs and mitotane...Finally, miR-885-5p and CEBPB were predicted as the upstream regulators of METTL1 through data mining of the public databases. In conclusions, m7G regulatory genes well represented by METTL1 profoundly affected the prognosis, tumor immune, therapeutic outcomes, and malignant progression of ACC.

almost 3 years ago

Journal • Tumor mutational burden

TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • MIR885 (MicroRNA 885) • NCBP1 (Nuclear Cap Binding Protein Subunit 1)

Lysodren (mitotane)