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    GENE:

    NCAPG (Non-SMC Condensin I Complex Subunit G)

    i
    Other names: NCAPG, Non-SMC Condensin I Complex Subunit G, Chromosome Condensation Protein G, Chromosome-Associated Protein G, Condensin Complex Subunit 3, Melanoma Antigen NY-MEL-3, Condensin Subunit CAP-G, XCAP-G Homolog, CAPG, Non-SMC Condensin I Complex, Subunit G, NY-MEL-3, NYMEL3, HCAP-G, CHCG, YCG1
    29d
    Discovery of Bufalin as a Molecular Glue Degrader of NCAPG to Inhibit the Proliferation of Hepatoma Cells. (PubMed, Drug Dev Res)
    Our study not only identified the CTSV-NCAPG complex as a novel therapeutic target but also discovered a potential molecular glue, bufalin, which exerts anti-proliferation effects through cell cycle regulation. These findings highlight the potential clinical translational value of bufalin as a promising, bioavailable therapeutic agent for the targeted treatment of liver cancer.
    Journal
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    CCND1 (Cyclin D1) • CDK1 (Cyclin-dependent kinase 1) • NCAPG (Non-SMC Condensin I Complex Subunit G)
    1m
    Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)
    The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.
    Journal
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    TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)
    3ms
    Comprehensive identification and validation of hub genes targeted by quercetin in hepatocellular carcinoma via integrated bioinformatics and experimental approaches. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
    Through multi-omics integration and experimental validation, this study identified six key genes closely associated with HCC and demonstrated the therapeutic potential of the natural compound quercetin via multi-target regulation. These findings provide theoretical and experimental support for targeted therapy and natural drug development in HCC.
    Journal
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    CDC20 (Cell Division Cycle 20) • NCAPG (Non-SMC Condensin I Complex Subunit G) • CCNB1 (Cyclin B1)
    3ms
    NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification. (PubMed, Cell Signal)
    Moreover, NCAPG promoted GPX4 expression in a NSUN2-dependent manner, which also promoted resistance to ferroptosis in HCC. Collectively, the current study identified NCAPG protected HCC cells from undergoing ferroptosis, emphasizing NCAPG as an optional target for potentially developing anti-cancer therapy and improving the effects of ferroptosis in HCC treatment.
    Journal
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    GPX4 (Glutathione Peroxidase 4) • NCAPG (Non-SMC Condensin I Complex Subunit G) • CAPG (Capping Actin Protein, Gelsolin Like) • NSUN2 (NOP2/Sun RNA Methyltransferase 2)
    3ms
    Integrated bioinformatics and Toxicogenomics reveal bisphenol A-driven molecular networks and prognostic biomarkers in endometrial cancer. (PubMed, Toxicol Res (Camb))
    BPA-related genes show significant differential expression and prognostic value in endometrial cancer, influencing clinical outcomes and immune infiltration. These findings highlight the potential for BPA exposure to affect endometrial carcinogenesis and offer valuable insights for developing therapeutic interventions.
    Journal
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    NCAPG (Non-SMC Condensin I Complex Subunit G) • HTR2B (5-Hydroxytryptamine Receptor 2B)
    6ms
    Deciphering the molecular landscape of acute myeloid leukemia initiation and relapse: a systems biology approach. (PubMed, Med Oncol)
    Our findings suggest that NCAPG, UBE2C, CDC20, CDK1, and SPP1 may serve as prognostic biomarkers for AML management, especially through their interaction with the p53 pathway in disease progression. These insights underscore the potential for targeting the p53 pathway and integrating these biomarkers to enhance outcomes for AML patients.
    Review • Journal
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    SPP1 (Secreted Phosphoprotein 1) • CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • NCAPG (Non-SMC Condensin I Complex Subunit G) • CAPG (Capping Actin Protein, Gelsolin Like) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    6ms
    CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination. (PubMed, J Transl Med)
    In conclusion, we have identified that CAFs-derived lactate promoted GC progression and clarified its mechanism, proposing the H3K18la-ASPM-NCAPG axis. Daturilin could enhance the therapeutic efficacy of anti-PD-1 treatment. This offers innovative perspectives on the complex role of CAFs in the TME and the influence of lactate on tumor progression.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    NCAPG (Non-SMC Condensin I Complex Subunit G) • CAPG (Capping Actin Protein, Gelsolin Like)
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    PD-L1 expression
    7ms
    Integrative analysis of CRISPR screening and gene expression data identifies a three-gene prognostic model associated with immune microenvironment in neuroblastoma. (PubMed, Transl Cancer Res)
    The three-gene prognostic model effectively stratifies neuroblastoma patients by survival risk and correlates with immune microenvironment characteristics. This model has potential clinical utility for prognosis prediction and guiding personalized immunotherapy strategies in neuroblastoma.
    Journal • IO biomarker
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    NCAPG (Non-SMC Condensin I Complex Subunit G) • PKMYT1 (Protein Kinase Membrane Associated Tyrosine/Threonine 1) • CDT1 (Chromatin Licensing And DNA Replication Factor 1)
    7ms
    Identification of Critical Genes Related to Breast Cancer with Brain Metastasis Through Bioinformatics Analysis. (PubMed, Curr Med Chem)
    The results of this study may aid in the early diagnosis and suggest potential targets for the treatment of BCBM.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • CCNA2 (Cyclin A2) • FOXM1 (Forkhead Box M1) • CDK1 (Cyclin-dependent kinase 1) • NCAPG (Non-SMC Condensin I Complex Subunit G) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CCNB1 (Cyclin B1)
    8ms
    RNA-Seq Uncovers Association of Endocrine-Disrupting Chemicals with Hub Genes and Transcription Factors in Aggressive Prostate Cancer. (PubMed, Int J Mol Sci)
    This is one of the first comprehensive studies combining 15 publicly available RNA-seq datasets to demonstrate the association of EDC-associated hub genes and their TFs aligning with the aggressive carcinogenic pathways in the higher age group (>60 years) of patients. The findings highlight the potential of these hub genes as candidates for further studies to develop molecular biomarkers for assessing the EDC-related PCa risk, diagnosing PCa aggressiveness, and identifying therapeutic targets.
    Journal
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    AR (Androgen receptor) • AURKA (Aurora kinase A) • CCNA2 (Cyclin A2) • YBX1 (Y-Box Binding Protein 1) • CCNB2 (Cyclin B2) • CDK1 (Cyclin-dependent kinase 1) • NCAPG (Non-SMC Condensin I Complex Subunit G) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CCNB1 (Cyclin B1) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    8ms
    NCAPG promotes epithelial-mesenchymal transition through SIP-dependent ubiquitination regulation of β-catenin in hepatocellular carcinoma. (PubMed, Cell Signal)
    Furthermore, we discovered that the disordered domain of NCAPG (D-NCAPG) serves as the specific binding sites for SIP binding. In conclusion, this study reveals the underlying mechanism by which NCAPG promotes EMT in HCC, which may be useful in the treatment of NCAPG-expressing HCC.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • NCAPG (Non-SMC Condensin I Complex Subunit G) • CAPG (Capping Actin Protein, Gelsolin Like)
    8ms
    Identification of prognosis-related key genes in hepatocellular carcinoma based on bioinformatics analysis. (PubMed, Zhong Nan Da Xue Xue Bao Yi Xue Ban)
    This study identified 16 key genes as potential prognostic biomarkers for hepatocellular carcinoma, among which ASPM and NCAPG may serve as promising blood-based markers for hepatocellular carcinoma.
    Journal
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    NCAPG (Non-SMC Condensin I Complex Subunit G)