^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    NBEA (Neurobeachin)

    i
    Other names: NBEA, Neurobeachin, BCL8B, LYST2, KIAA1544, Lysosomal-Trafficking Regulator, FLJ10197, Protein BCL8B, NEDEGE
    10d
    Identification and Validation of an Autophagy-Related Gene Signature for Prognostic Prediction and Immunotherapy Response in Esophageal Squamous Cell Carcinoma. (PubMed, Cancers (Basel))
    We developed a novel 4-ARGs prognostic model and identified NLRX1 as a potential autophagy-dependent biomarker. These findings underscore its utility as a valuable tool for prognosis, risk stratification, and therapy guidance in ESCC.
    Journal • Gene Signature • IO biomarker
    |
    MAGEA3 (MAGE Family Member A3) • NBEA (Neurobeachin)
    7ms
    Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss. (PubMed, Diabetes Obes Metab)
    These findings indicate that NBEA genetic variation is predictive of GLP-1RA weight loss and may support future efforts to identify individuals likely to experience significant weight loss with GLP-1RAs, enabling personalised obesity treatment strategies.
    Journal
    |
    NBEA (Neurobeachin)
    over1year
    Dense but not alpha granules of platelets are required for insulin secretion from pancreatic β cells. (PubMed, Biochem Biophys Res Commun)
    Obtained data suggest that DGs, but not AGs, mediate the influence of platelets on pancreatic β cells, thereby modulating glucose metabolism.
    Journal
    |
    NBEA (Neurobeachin) • UNC13D (Unc-13 Homolog D)
    almost2years
    Genetic alterations in the neuronal development genes are associated with changes of the tumor immune microenvironment in pancreatic cancer. (PubMed, Ann Pancreat Cancer)
    In contrast, the copy number gain in fewer genes, including NRXN3, ZNF667, ACSM3, C6, ADCY5, SCN9A, and PRKCE, is significantly associated with changes in immune cell infiltrates. Our study suggested that neuronal development genes play a role in modulating TME in a pancreatic cancer setting.
    Journal
    |
    NRG1 (Neuregulin 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • NCAM1 (Neural cell adhesion molecule 1) • ACSM3 (Acyl-CoA Synthetase Medium Chain Family Member 3) • CFTR (CF Transmembrane Conductance Regulator) • NBEA (Neurobeachin) • PKHD1 (PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin) • PRKCE (Protein Kinase C Epsilon) • MAPK10 (Mitogen-Activated Protein Kinase 10)
    almost3years
    Tumor cell-intrinsic factors promoting fibrotic tumor microenvironment in gastric cancer (AACR 2023)
    Bioinformatic analyses of a publicly available genomic and transcriptomic dataset revealed a fibroblast-rich and immune-excluded population in GC patients. Several GPCR signaling in tumor cells were strongly correlated with fibroblast abundance in tumors, and these signaling pathways have potential roles in promoting the stroma-rich GC microenvironment.
    Tumor cell
    |
    CD8 (cluster of differentiation 8) • NBEA (Neurobeachin) • CALCRL (Calcitonin Receptor Like Receptor)
    over3years
    Mutational Signature and Integrative Genomic Analysis of Human Papillomavirus-Associated Penile Squamous Cell Carcinomas from Latin American Patients. (PubMed, Cancers (Basel))
    Additionally, four cancer-associated genes (CARD11, CSMD3, KDR, and TLX3) carried untranslated regions (UTRs) variants, which may impact gene regulation by affecting the miRNAs hybridization regions. Altogether, these data contribute to the characterization of the mutational spectrum and its impact on cellular signaling pathways in PSCC, thus reinforcing the pivotal role of HPV infection in the molecular pathogenesis of these tumors.
    Journal
    |
    TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • NOTCH1 (Notch 1) • TERT (Telomerase Reverse Transcriptase) • KDR (Kinase insert domain receptor) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • KMT2C (Lysine Methyltransferase 2C) • FAT1 (FAT atypical cadherin 1) • TTN (Titin) • CARD11 (Caspase Recruitment Domain Family Member 11) • CASP8 (Caspase 8) • RAD21 (RAD21 Cohesin Complex Component) • AJUBA (Ajuba LIM Protein) • CSMD3 (CUB And Sushi Multiple Domains 3) • NBEA (Neurobeachin) • PLAG1 (PLAG1 Zinc Finger)
    |
    TP53 mutation • TERT mutation
    over3years
    A Novel Artificial Neural Network Prognostic Model Based on a Cancer-Associated Fibroblast Activation Score System in Hepatocellular Carcinoma. (PubMed, Front Immunol)
    5-Fluorouracil had higher sensitivity in high-CAS samples than in low-CAS samples...We constructed a novel ANN model based on CAF-related genes. We revealed information about the ANN model through functional, mutational, immune, and clinical analyses.
    Journal
    |
    NBEA (Neurobeachin)
    |
    5-fluorouracil
    4years
    Coexistence of a novel NBEA-ALK, EML4-ALK double-fusion in a lung adenocarcinoma patient and response to alectinib: A case report. (PubMed, Lung Cancer)
    This is the first report on one patient with a novel NBEA-ALK, EML4-ALK double-ALK fusion beneficial from alectinib. Alectinib may be a viable therapeutic option for NSCLC patients with double-ALK fusion, and liquid biopsy could dynamically monitor clinical curative effect.
    Clinical • Journal
    |
    ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4) • NBEA (Neurobeachin)
    |
    ALK rearrangement • EML4-ALK fusion • ALK fusion • NBEA-ALK fusion + EML4-ALK fusion
    |
    Alecensa (alectinib)