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GENE:

NAPSB (Napsin B Aspartic Peptidase)

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Other names: NAPSB, Napsin B Aspartic Peptidase, Pseudogene, NAPSBP, NAP1L, NAP2, NAPB, Napsin A Aspartic Peptidase Pseudogene, Napsin B Pseudogene, Napsin-A Pseudogene, Pronapsin B, Napsin 2
5ms
Preoperative factors influence technique selection in surgical management of small bowel obstruction: findings from the SnapSBO multinational prospective observational study. (PubMed, Surg Endosc)
Preoperative patient factors and disease etiology are associated with initial operative technique selection, while intraoperative events and findings appear to adjust the probability of conversion to open. Preoperative assessment combined with flexibility in intraoperative decision-making appears to be associated with optimal outcomes in SBO management.
Observational data • Journal
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NAPSB (Napsin B Aspartic Peptidase)
11ms
Early-Stage Lung Cancer Diagnosis by a Point-of-Care Electrochemical Aptamer-Based Sensor of NAP2 in Human Serum. (PubMed, Anal Chem)
Importantly, this E-AB-GC POCT platform has shown potential as an on-site quick diagnostic tool, which can also be used to detect other lung cancer markers. Our research on the impacts of stem sequencing on sensing capabilities might assist in the future development of E-AB biomarker sensors.
Journal
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NAPSB (Napsin B Aspartic Peptidase)
12ms
Data-Driven Identification of Early Cancer-Associated Genes via Penalized Trans-Dimensional Hidden Markov Models. (PubMed, Biomolecules)
Our approach outperforms two other leading methods, yielding robust findings and identifying novel differentially methylated cytosines. We found that CRC patient survival time follows a two-component mixture regression model, where genes CDH11, EPB41L3, and DOCK2 are active in the more aggressive form of CRC, whereas TMEM215, PPP1R14A, GPR158, and NAPSB are active in the less aggressive form.
Journal
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NAPSB (Napsin B Aspartic Peptidase) • CDH11 (Cadherin 11) • EPB41L3 (Erythrocyte Membrane Protein Band 4.1 Like 3)
over2years
NAP1L5 facilitates pancreatic ductal adenocarcinoma progression via TRIM29-mediated ubiquitination of PHLPP1. (PubMed, Biochem Pharmacol)
Our findings indicate that NAP1L5 overexpression promotes the proliferation of PDAC cells by inhibiting PHLPP1 expression. These novel insights suggest that NAP1L5 may serve as a potential therapeutic target for PDAC.
Journal
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PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1) • NAPSB (Napsin B Aspartic Peptidase) • TRIM29 (Tripartite Motif Containing 29)
over2years
Analytical Validation of a Laboratory-Developed Lung Nodule Risk Reclassifier Assay. (PubMed, J Appl Lab Med)
The lung nodule risk reclassifier assay performed as required to be offered as an LDT in the MagArray CLIA-certified laboratory.
Journal
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EGFR (Epidermal growth factor receptor) • CEACAM5 (CEA Cell Adhesion Molecule 5) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • NAPSB (Napsin B Aspartic Peptidase)
almost3years
A Prognostic Model of Pseudogenes in Acute Myeloid Leukemia. (PubMed, Clin Lab)
The prognostic model of pseudogenes we identified is an independent predictor of overall survival in AML and could be used as biomarker for AML treatment.
Journal
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NAPSB (Napsin B Aspartic Peptidase) • PDCD6IP (Programmed Cell Death 6 Interacting Protein)