[VIRTUAL] Colorectal Cancer (CRC) (ASCO 2021)
Clinical and biologic factors influencing the selection and sequencing of therapy for patients with CRC Key efficacy and safety results from the Phase III KEYNOTE-177 study of first-line pembrolizumab versus chemotherapy for patients with MSI-high/mismatch repair-deficient (MSI-H/dMMR) unresectable or metastatic CRC; FDA approval of pembrolizumab as first-line therapy and implications for clinical practice Correlation between the location of the primary tumor and outcomes with EGFR antibody-based regimens; optimal incorporation of cetuximab and panitumumab into current metastatic CRC treatment algorithms Current clinical role of anti-PD-1 monotherapy (eg, nivolumab, pembrolizumab) and nivolumab/ipilimumab in the care of patients with MSI-H/dMMR relapsed or refractory metastatic CRC Ongoing investigations of immune checkpoint inhibitors alone or in combination with other systemic approaches (eg, chemotherapy, targeted therapy) in MSI-H/dMMR early-stage and advanced CRC (eg, CheckMate 8HW) Optimal selection of first-line therapy for patients with BRAF wild-type, microsatellite stable (MSS) metastatic CRC Biologic rationale for, available data with and ongoing Phase III investigations combining an anti-angiogenic agent with an immune checkpoint inhibitor (eg, LEAP-017) for patients with previously treated MSS metastatic CRC Findings from early-phase studies (eg, REGOMUNE, CAVE, ILLUMINATE-206) and ongoing evaluation of regimens combining immune checkpoint inhibitors with different systemic therapies (eg, regorafenib, cetuximab) in MSS metastatic CRC Key efficacy and safety findings from the Phase III BEACON CRC trial of encorafenib/cetuximab with or without binimetinib for patients with BRAF V600E-mutant metastatic CRC; FDA approval of encorafenib/cetuximab and appropriate integration into clinical practice Design, eligibility criteria and available efficacy results from the Phase II ANCHOR-CRC trial evaluating encorafenib, binimetinib and cetuximab in patients with previously untreated BRAF V600E-mutant metastatic CRC Incidence of HER2 overexpression and HER2 mutations in CRC; key efficacy findings from the Phase II DESTINY-CRC01 study of T-DXd for patients with HER2-expressing advanced CRC Spectrum, incidence and severity of toxicities associated with T-DXd in the DESTINY-CRC01 trial Available data with and ongoing investigations of HER2-directed approaches in advanced CRC (eg, HERACLES, DASH, DESTINY-CRC02, MOUNTAINEER) Long-term efficacy and safety findings with and clinical, biologic and/or practical factors influencing the sequencing of regorafenib and TAS-102 Available data with and potential role of TAS-102 in combination with bevacizumab or other systemic agents in metastatic CRC and/or in earlier disease stages Mechanism of action of napabucasin; implications of the negative results from the Phase III CanStem303C trial of napabucasin in combination with FOLFIRI with or without bevacizumab for previously treated metastatic CRC Other promising agents and strategies under investigation in CRC