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    GENE:

    NANOGNB (NANOG Neighbor Homeobox)

    i
    Other names: NANOGNB, NANOG Neighbor Homeobox, Homeobox Protein C14, Homeobox C14
    1year
    In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma. (PubMed, Front Immunol)
    Notably, LUAD-7-MT peptide encoded by NANOGNB demonstrated higher immunogenicity in promoting CD8+ T cells proliferation and IFN-γ secretion than the corresponding wildtype peptide. This study provides an in-depth analysis of mutation characteristics of LUAD and establishes a neoantigen screening and validation system for identifying immunogenicity neopeptide across individual patients and diverse foci in the same patient with multifocal LUAD.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • NANOGNB (NANOG Neighbor Homeobox)
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    TMB-H