NANOG (Nanog Homeobox)

In CD44+ PCSCs, HA-SeNP-Api produced the strongest cytotoxicity in the MTT assay (14.61% viability), exceeding the effects of apigenin, enzalutamide, SeNP, and non-targeted SeNP-Api (HA-)...Intracellular ROS profiling further indicated redox modulation by SeNP-containing formulations, with partial attenuation by NAC, supporting a ROS-linked contribution to the observed apoptotic response. Collectively, HA-SeNP-Api integrates CD44-mediated targeting with redox-driven stress signaling to achieve potent anti-PCSC activity, supporting further preclinical evaluation.

RNA-seq and functional studies further revealed that HCAR1 critically regulates GCSC self-renewal and antioxidant defense, and ARBU promoted ferroptosis via HCAR1 suppression. Collectively, these results demonstrate that ARBU inhibits GCSC proliferation and stemness by inducing ferroptosis through downregulation of the HCAR1 pathway, highlighting its potential as a therapeutic candidate for gastric cancer.

As effective CSC phenotypic depletion is critical in preventing recurrence and metastasis in ovarian cancer, ketone analog (4) may serve as a selective modulator in contexts requiring partial CSC inhibition. Ketone analog (5) broad pharmacological suppression of CSC programs could position it as a promising candidate for combination therapy to overcome VM-driven chemoresistance.

These results emphasize the pivotal role of AXL in regulating both stemness and hedgehog signaling in HER2-positive breast cancer. The study suggests that targeting both AXL and HER2 could be a promising strategy to overcome trastuzumab resistance and improve treatment outcomes.

A metastatic CSC subpopulation present in NPC express CXCR4 and have activated EMT and SDF-1/CXCR4-driven metastasis. CXCR4 may have utility as a biomarker and the SDF-1/CXCR4 axis may be a therapeutic target for NPC.

Therefore, restoring immune recognition and inhibition of proliferation. Hence, thymoquinone could be a potent target for breast cancer therapeutics.

Blue light irradiation reduced viability and migration in both OSCC cell lines and induced apoptosis only in non-metastatic SCC9 cells. Blue light exerted anti-tumor effects without promoting cancer stem cells properties, while decreasing their ability to self-renew.

This activation induces the transcription of Nanog homeobox (NANOG) and POU class 5 homeobox 1 (POU5F1/OCT4), thereby sustaining NSCLC stemness. Collectively, these findings identify a previously unrecognized LINK-A/hnRNPK/USP9X/β-catenin signaling axis and highlight LINK-A as a potential biomarker and therapeutic target for NSCLC.

Media-dependent plasticity was evident in the Bobby line. These models retain key epithelial and stemness features and provide robust platforms for translational prostate cancer research in dogs and humans.

We have created a robust and valuable iPSC collection aimed at correlating the in vivo confirmed clinical and pathological variants with the in vitro phenotypes. This unique tool can contribute to the understanding of MSA pathophysiology, the discovery of therapeutic targets, and the development of therapeutic screening approaches.

Furthermore, lycorine sensitized ovarian cancer cells to cisplatin and counteracted cisplatin-induced enrichment of cancer stem cell populations. These findings highlight lycorine as a promising multi-target therapeutic agent for ovarian cancer, particularly in addressing stemness-driven chemoresistance and tumor recurrence.

This reduction in genomic stress markers was associated with preservation of cellular function and delayed onset of senescence. Collectively, these findings identify DDR1 as a critical regulator of MSC aging and genomic stability and establish AC-4067 as a promising pharmacological agent for preserving MSC functional integrity and enhancing their therapeutic potential in regenerative medicine.