MB (Myoglobin)

Cleavages at Pro residues showed enhanced digestion in the PRR of the tumor suppressor protein p53, where conventional proteases show limited activity. These results confirm NEP-NAT as a potent protease in proteomics workflows, offering enhanced access to Pro-rich and disordered domains that are largely inaccessible to common proteases.

The rapid onset of rhabdomyolysis following ERCP raises the possibility that tumor manipulation or antigenic exposure may serve as an immune trigger for paraneoplastic muscle injury.

P=N/A, N=100, Recruiting, KU Leuven | Trial completion date: Dec 2026 --> Dec 2028 | Trial primary completion date: Dec 2026 --> Dec 2028

We report a fulminant case of overlap syndrome involving ICI-induced myositis and myasthenia gravis in a 72-year-old man receiving ipilimumab-nivolumab for hepatocellular carcinoma and recurrent renal cell carcinoma...Despite prompt intensive care admission and treatment with high-dose intravenous methylprednisolone and intravenous immunoglobulin, only partial clinical improvement was achieved. The subsequent development of aspiration pneumonia led to acute respiratory and hepatic failure, culminating in death. This case underscores the aggressive clinical trajectory and high mortality of ICI-related neuromuscular overlap syndromes, highlighting the critical need for early recognition, rapid immunosuppression, and multidisciplinary management.

These findings reinforce the existence of an integrated axis between metabolism, inflammation, and behavior, in which excess weight, sedentary lifestyle, and nutritional deficiencies synergistically contribute to the maintenance of psychiatric symptoms and metabolic vulnerability. Integrating biomarkers, BMI, and behavioral factors may aid in identifying clinical subphenotypes and guiding more precise and individualized therapeutic strategies.

Additionally, in hepatocellular carcinoma (HCC), a dominant m.2356C > G clone correlated with POLR2A activation and widespread transcriptional amplification, consistent with a mitochondria-nucleus signaling axis contributing to adverse prognosis in this cancer type. Collectively, these findings establish MitoBayes as a robust statistical framework linking mitochondrial genetic diversity to disease phenotypes and highlight mitochondrial clonal selection as a mechanistically and clinically actionable target for therapeutic and diagnostic development.

This review aims to discuss the different functions of myoglobin, with a particular emphasis on reviewing its role as a pathogenic factor and therapeutic factor in various diseases. Additionally, we have also explored the related mechanisms to provide theoretical support for further investigation into myoglobin's function in disease contexts.

The precise pathogenic role of this antibody in systemic autoimmunity remains undefined, and systematic evidence linking it to rhabdomyolysis is lacking. Future multi-omic profiling and functional studies are required to determine whether the two disorders share a common mechanistic pathway.

IHC and molecular analyses are crucial for an accurate diagnosis, particularly in tumors with heterologous elements that may mimic other sarcomas or germ cell tumors. Early recognition and multidisciplinary management optimize local control and surveillance planning.

Severe focal calcification may produce mechanical compression and cell necrosis, disrupt electrical coupling, create electrically silent zones, and result in pathological Q waves. In CKD patients with abnormal ECG findings, myocardial calcification should be included in the differential diagnosis and evaluated using imaging and metabolic data.

CT radiomics can effectively characterize lung cancer heterogeneity. Integrating clinical laboratory data, radiomic features, and radiomic subtype information provides optimal predictive performance for platinum resistance.

Complex 1 exhibited selective cytotoxicity, significantly reducing the cell viability of A375 cells in a dose-dependent manner while having a lower effect on HaCaT cells, suggesting its antitumor potential against melanoma. In contrast, the precursor complex [Mo(η3-C3H5)Cl(CO)2(CH3CN)2] showed reduced activity against A375 cells and higher toxicity toward HaCaT cells, highlighting the beneficial impact of the bidentate 3-(2-pyridyl)pyrazole ligand.