MB (Myoglobin)

This review aims to discuss the different functions of myoglobin, with a particular emphasis on reviewing its role as a pathogenic factor and therapeutic factor in various diseases. Additionally, we have also explored the related mechanisms to provide theoretical support for further investigation into myoglobin's function in disease contexts.

The precise pathogenic role of this antibody in systemic autoimmunity remains undefined, and systematic evidence linking it to rhabdomyolysis is lacking. Future multi-omic profiling and functional studies are required to determine whether the two disorders share a common mechanistic pathway.

IHC and molecular analyses are crucial for an accurate diagnosis, particularly in tumors with heterologous elements that may mimic other sarcomas or germ cell tumors. Early recognition and multidisciplinary management optimize local control and surveillance planning.

Severe focal calcification may produce mechanical compression and cell necrosis, disrupt electrical coupling, create electrically silent zones, and result in pathological Q waves. In CKD patients with abnormal ECG findings, myocardial calcification should be included in the differential diagnosis and evaluated using imaging and metabolic data.

CT radiomics can effectively characterize lung cancer heterogeneity. Integrating clinical laboratory data, radiomic features, and radiomic subtype information provides optimal predictive performance for platinum resistance.

Complex 1 exhibited selective cytotoxicity, significantly reducing the cell viability of A375 cells in a dose-dependent manner while having a lower effect on HaCaT cells, suggesting its antitumor potential against melanoma. In contrast, the precursor complex [Mo(η3-C3H5)Cl(CO)2(CH3CN)2] showed reduced activity against A375 cells and higher toxicity toward HaCaT cells, highlighting the beneficial impact of the bidentate 3-(2-pyridyl)pyrazole ligand.

P=N/A, N=2500, Not yet recruiting, The Third Affiliated Hospital Sun Yat-sen University; The Third Affiliated Hospital Sun Yat-sen University

P=N/A, N=654, Not yet recruiting, Jiangnan University; Jiangnan University

P=N/A, N=198, Completed, Shanghai Fourth People's Hospital, School of Medicine, Tongji University; Shanghai Fourth People's Hospital, School of Medicine, Tongji University

P1, N=9, Recruiting, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

A 67-year-old male patient with advanced rectal cancer and multiple metastases received chemotherapy with oxaliplatin and capecitabine, targeted therapy with bevacizumab, denosumab for bone metastases, and local radiotherapy. However, when the condition deteriorated and the number of metastatic lesions increased, the expression levels of myocardial enzymes sharply rose again, eventually accompanying the patient's death. The non-cardiac injury-related increase in myocardial enzymes is closely associated with tumor burden and cancer activity, and can serve as a dynamic indicator for evaluating the efficacy of radiotherapy and chemotherapy and disease progression.

Thus, the potential for AGE10 as a diagnostic marker is limited. The implications concern the biology of this epitope, the unique tissue distribution, and a role in cellular metabolism.