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    BIOMARKER:

    MYCL overexpression

    i
    Other names: MYCL, MYCL Proto-Oncogene BHLH Transcription Factor, Class E Basic Helix-Loop-Helix Protein 38, Myc-Related Gene From Lung Cancer, Protein L-Myc-1, Protein L-Myc, BHLHe38 , MYCL1, LMYC, V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 1 Lung Carcinoma Derived 2, V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog 3, V-Myc Myelocytomatosis Viral Oncogene Homolog 1 Lung Carcinoma Derived 3, V-Myc Myelocytomatosis Viral Oncogene Homolog, L-Myc-1 Proto-Oncogene, L-Myc Prote
    Entrez ID:
    4610
    Related biomarkers:
    Expression
    CNA
    over3years
    MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity. (PubMed, Genes Dev)
    MYCN overexpression also suppressed response to cisplatin-etoposide chemotherapy, with similar findings made upon MYCL overexpression. Pharmacological inhibition of USP7 resensitized chemoresistant MYCN-overexpressing PDX models to chemotherapy in vivo. Our findings show that MYCN overexpression drives SCLC chemoresistance and provide a therapeutic strategy to restore chemosensitivity.
    Journal
    |
    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • MYCL (MYCL Proto-Oncogene BHLH Transcription Factor)
    |
    MYCN amplification • MYCL overexpression
    |
    cisplatin • etoposide IV