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GENE:

MX1 (MX Dynamin Like GTPase 1)

News alerts, weekly reports and conference planners

24d

Prediction of outcome from spatial Protein profiling of triple-negative breast cancers. (PubMed, Commun Med (Lond))

Our results show that unbiased protein-based and segmentation-free spatial analysis is effective for identifying clinically relevant biomarkers from multiplex tumor images and identifying predictive biology.

24 days ago

Journal

VIM (Vimentin) • MX1 (MX Dynamin Like GTPase 1)

26d

Integrated Transcriptomic and Machine Learning Analysis Reveals Immune-Related Regulatory Networks in Anti-NMDAR Encephalitis. (PubMed, Int J Mol Sci)

Pathway and immune profiling analyses demonstrated convergence of canonical immune signaling pathways, including JAK-STAT and PI3K-Akt, with neuronal communication modules, accompanied by enhanced innate immune signatures. Although limited by reliance on public datasets and small sample size, these findings delineate a systems-level neuroimmune regulatory program in anti-NMDAR encephalitis and provide a scalable, network-based multi-omics framework for investigating immune-mediated neurological and autoimmune disorders and for guiding future experimental validation.

26 days ago

Journal

MIR22 (MicroRNA 22) • MX1 (MX Dynamin Like GTPase 1) • ACVR2B (Activin A Receptor Type 2B)

2ms

Transcriptomic profiling reveals early immune activation and metabolic remodeling in lymphoid tissues following in ovo Marek's disease virus mRNA vaccination in chickens. (PubMed, Vet Immunol Immunopathol)

In contrast, the bursa exhibited persistent modulation of colipase (CLPS), chymotrypsinogen B1 (CTRB1), and deoxyribonuclease I (DNASE1), indicating metabolic and apoptotic remodeling. These results demonstrate that in ovo mRNA vaccination against MDV rapidly activates organ-specific immune and metabolic pathways, providing a transcriptomic framework for the rational design of poultry mRNA vaccines.

2 months ago

Journal

STAT1 (Signal Transducer And Activator Of Transcription 1) • OASL (2'-5'-Oligoadenylate Synthetase Like) • CDX1 (Caudal type homeobox 1) • MX1 (MX Dynamin Like GTPase 1)

3ms

Integrated multi-omics and molecular docking reveal shared molecular mechanisms of helicobacter pylori infection and rheumatic diseases. (PubMed, Int J Surg)

This study revealed the immune/viral pathways and hub genes linking H. pylori to rheumatic diseases, suggesting potential therapeutic targets.

3 months ago

Journal

CXCL10 (Chemokine (C-X-C motif) ligand 10) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • TLR4 (Toll Like Receptor 4) • STAT1 (Signal Transducer And Activator Of Transcription 1) • ITGB2 (Integrin Subunit Beta 2) • MX1 (MX Dynamin Like GTPase 1) • RELA (RELA Proto-Oncogene)

atorvastatin

4ms

MX1 is a novel crucial prognostic and therapeutic target inducing chemoresistance in right-sided colon cancer: insights from machine learning-based multi-omics analysis. (PubMed, Hum Genomics)

A prognostic model based on primary location-related genes was developed to predict prognosis and chemotherapy response in RCC. MX1 was identified as a pivotal target that promotes angiogenesis and chemoresistance, thereby providing a potential therapeutic strategy for patients with RCC.

4 months ago

Journal

SLC35A2 (Solute Carrier Family 35 Member A2) • MX1 (MX Dynamin Like GTPase 1)

5ms

A new serological autoantibody signature associated with multiple sclerosis. (PubMed, Neurobiol Dis)

While MX1 has previously been implicated in MS, this is the first report of autoantibody reactivity against the protein, suggesting a potential role in disease onset and progression. These findings support a link between antiviral immune responses and MS pathophysiology and offer a promising blood-based autoantibody signature that could inform future diagnostic and therapeutic strategies.

5 months ago

Journal

SOX10 (SRY-Box 10) • MX1 (MX Dynamin Like GTPase 1)

5ms

Implementing Photodynamic Therapy to Activate the IFN-1 Pathway in Melanoma Cells: A Protocol for Inducing Immunogenic Cell Death and Enhancing Dendritic Cell Maturation. (PubMed, Methods Mol Biol)

We further discuss the consequential IFN-1-dependent-phenotypic maturation of monocyte-derived dendritic cells (DCs), evidenced by increased expression of co-stimulatory molecules such as CD80 and MHC-II and enhanced tumor-directed chemotaxis. By detailing the protocol for this novel application of PDT, this chapter aims to facilitate its integration into immunotherapy regimens, providing a comprehensive toolkit for researchers and clinicians aiming to harness the antitumor potential of the IFN-1 pathway.

5 months ago

Journal • IO biomarker

CXCL10 (Chemokine (C-X-C motif) ligand 10) • IFNA1 (Interferon Alpha 1) • CD80 (CD80 Molecule) • MX1 (MX Dynamin Like GTPase 1)

6ms

Novel Nanoadjuvant for Subunit Vaccines: Cyclic Seven-Membered Tertiary Amine-Based Polymer-Grafted Ethoxy-Acetalated Dextran Nanoparticles Encapsulating CpG Oligodeoxynucleotides. (PubMed, Mol Pharm)

More importantly, vaccination with 9NHAc-GD2-mQβ VLPs (a leading TACA vaccine candidate) plus Ace-Dex-PC7A@CpG significantly suppressed liver metastasis in an EL4 lymphoma model. These findings establish Ace-Dex-PC7A@CpG as a versatile nanoadjuvant for subunit vaccines against infectious diseases and cancer.

6 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • STING (stimulator of interferon response cGAMP interactor 1) • IFNB1 (Interferon Beta 1) • MX1 (MX Dynamin Like GTPase 1)

7ms

A randomized, open-label, multicenter clinical study comparing the combination of epalorlimovalizumab and bevacizumab with TAS-102 versus bevacizumab combined with TAS-102 in the second-line treatment of advanced colorectal cancer (ChiCTR2500106797)

P4, N=84, Not yet recruiting, Henan Cancer Hospital; Henan Cancer Hospital

7 months ago

New P4 trial

CXCL10 (Chemokine (C-X-C motif) ligand 10) • SPP1 (Secreted Phosphoprotein 1) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • GBP5 (Guanylate Binding Protein 5) • STAT1 (Signal Transducer And Activator Of Transcription 1) • APOE (Apolipoprotein E) • GBP1 (Guanylate Binding Protein 1) • TAP1 (Transporter 1) • GBP4 (Guanylate Binding Protein 4) • MX1 (MX Dynamin Like GTPase 1) • SDC2 (Syndecan 2)

Avastin (bevacizumab) • Lonsurf (trifluridine/tipiracil) • Qibeian (iparomlimab/tuvonralimab) • iparomlimab (QL1604)

8ms

Whole-Genome and RNA Sequencing Reveal Novel Insights into the Pathogenesis of Colorectal Cancer in Persons Living with HIV. (PubMed, AIDS Res Hum Retroviruses)

We found highly analogous insertions, deletions, and functional annotations of the detected single nucleotide polymorphisms and indel mutations in PWH and patients with HIV-negative CRC. This study provides new insights into crucial ISGs, immune infiltration, immune variants, and pathways involved in CRC with HIV infection.

8 months ago

Journal

FGF2 (Fibroblast Growth Factor 2) • EGF (Epidermal growth factor) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • CCL3 (C-C Motif Chemokine Ligand 3) • MX1 (MX Dynamin Like GTPase 1)

10ms

Transcriptome insights into newcastle disease virus-mediated eradication of cholangiocarcinoma cells. (PubMed, PLoS One)

In addition, gene network analysis highlighted CCNA2, CDK1, DDX58, DHX58, EXO1, GBP1, IFIH1, IFIT1, IFIT2, IFIT3, IRF7, ISIG15, MX1, OAS1, OAS2, PARP9, TOP2A and XAF1 as potential hub genes influencing the response of CCA cells to NDV LaSota strain. Our findings offer evidence supporting the promise of NDV-based therapies as potential strategies for eliminating CCA cells.

10 months ago

Journal • PARP Biomarker

CXCR4 (Chemokine (C-X-C motif) receptor 4) • TOP2A (DNA topoisomerase 2-alpha) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TGM2 (Transglutaminase 2) • CCNA2 (Cyclin A2) • IFIT1 (Interferon Induced Protein With Tetratricopeptide Repeats 1) • CDK1 (Cyclin-dependent kinase 1) • GBP1 (Guanylate Binding Protein 1) • IFIH1 (Interferon Induced With Helicase C Domain 1) • DDX58 (DExD/H-Box Helicase 58) • IFIT2 (Interferon Induced Protein With Tetratricopeptide Repeats 2) • IRF7 (Interferon Regulatory Factor 7) • MX1 (MX Dynamin Like GTPase 1) • XAF1 (XIAP Associated Factor 1)

10ms

CD86 is linked to apoptosis in canine histiocytic sarcoma. (PubMed, Front Vet Sci)

The findings indicate relevant differences in CD80 and CD86 expression between organs and a function in histiocytic disease in dogs. Further, the expression of markers of the interferon-type-I pathway indicates a role in immune evasion.

10 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

BIRC5 (Baculoviral IAP repeat containing 5) • STING (stimulator of interferon response cGAMP interactor 1) • CASP3 (Caspase 3) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • MX1 (MX Dynamin Like GTPase 1)