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    BIOMARKER:

    MVP expression

    i
    Other names: MVP, Major Vault Protein, LRP, Lung Resistance-Related Protein, VAULT1, Testicular Secretory Protein Li 30
    Entrez ID:
    9961
    10ms
    USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer. (PubMed, Cell Death Differ)
    Finally, we demonstrate that statins synergise with a dual USP28/25 inhibitor to reduce viability of SCC cells. Our findings suggest that combinatorial targeting of MVP and USP28 could be a therapeutic strategy for the treatment of squamous cell carcinomas.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • STK11 (Serine/threonine kinase 11) • MVP (Major Vault Protein)
    |
    KRAS mutation • MVP expression • KRAS deletion
    over1year
    Correlation of expression of Major Vault Protein with androgen receptor and immune checkpoint protein B7-H3, and with poor prognosis in prostate cancer. (PubMed, Pathol Res Pract)
    Our findings support the notion that expression of MVP is associated with poor prognosis in prostate cancer. The correlation between MVP and immune checkpoint protein B7-H3 in prostate cancer suggests a role for MVP in immunoregulation and drug resistance.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • PTEN (Phosphatase and tensin homolog) • AR (Androgen receptor) • CD276 (CD276 Molecule) • MVP (Major Vault Protein)
    |
    PTEN expression • AR expression • MVP expression
    over1year
    Cellular, Molecular and Proteomic Characteristics of Early Hepatocellular Carcinoma. (PubMed, Curr Issues Mol Biol)
    When taken in combination, this covers the 100% of the patients with early HCC. miR-200b, APOA2 and APOC3 proteins are sensitive markers and can be potentially useful in combination for the early diagnosis of HCC.
    Journal
    |
    AFP (Alpha-fetoprotein) • EPCAM (Epithelial cell adhesion molecule) • MIR200B (MicroRNA 200b) • VIM (Vimentin) • MIR200A (MicroRNA 200a) • MIR221 (MicroRNA 221) • MVP (Major Vault Protein) • APOC3 (Apolipoprotein C3) • MIR122 (MicroRNA 122) • MIR222 (MicroRNA 222)
    |
    MVP expression
    2years
    Major Vault Protein (MVP) Associated With BRAF Mutation Is an Immune Microenvironment-Related Biomarker Promoting the Progression of Papillary Thyroid Cancer via MAPK/ERK and PI3K/AKT Pathways. (PubMed, Front Cell Dev Biol)
    Mechanistically, MVP exerts its oncogenic function in PTC cells through activating PI3K/AKT/mTOR and MAPK/ERK pathways. These results point out that MVP is a reliable biomarker related to the immune microenvironment and provide a basis for elucidating the oncogenic roles of MVP in PTC progression.
    Journal
    |
    BRAF (B-raf proto-oncogene) • CD8 (cluster of differentiation 8) • MVP (Major Vault Protein)
    |
    BRAF mutation • CD8 expression • MVP expression