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DRUG:

MVA-BN-Brachyury IV vaccine

i
Other names: MVA-BN-Brachyury IV vaccine
Associations
Company:
Bavarian Nordic
Drug class:
Immunostimulant
Related drugs:
Associations
3years
Phase 1 open-label trial of intravenous administration of MVA-BN-brachyury-TRICOM vaccine in patients with advanced cancer. (PubMed, J Immunother Cancer)
Intravenous administration of MVA-BN-brachyury-TRICOM vaccine was safe and tolerable. Maximum tolerated dose was not reached. The maximum administered dose was 10 infectious units every 3 weeks for three doses. This dose was selected as the recommended phase 2 dose.
Clinical • P1 data • Journal
|
CD8 (cluster of differentiation 8)
|
BN-Brachyury • MVA-BN-Brachyury IV vaccine
over3years
Clinical • Trial completion
|
EGFR (Epidermal growth factor receptor) • BRAF (B-raf proto-oncogene) • ER (Estrogen receptor) • ALK (Anaplastic lymphoma kinase) • PGR (Progesterone receptor)
|
ALK fusion • ER positive + PGR positive • PGR positive
|
MVA-BN-Brachyury IV vaccine
almost4years
Clinical • Enrollment closed
|
EGFR (Epidermal growth factor receptor) • BRAF (B-raf proto-oncogene) • ER (Estrogen receptor) • ALK (Anaplastic lymphoma kinase) • PGR (Progesterone receptor)
|
ALK fusion • ER positive + PGR positive • PGR positive
|
MVA-BN-Brachyury IV vaccine
almost5years
A Phase 1 Open Label Trial of Intravenous Administration of MVA-BN-Brachyury Vaccine in Patients With Advanced Cancer (clinicaltrials.gov)
P1, N=18, Recruiting, Bavarian Nordic | Trial completion date: Nov 2020 --> Mar 2021 | Trial primary completion date: Aug 2020 --> Dec 2020
Clinical • Trial completion date • Trial primary completion date
|
EGFR (Epidermal growth factor receptor) • BRAF (B-raf proto-oncogene) • ER (Estrogen receptor) • ALK (Anaplastic lymphoma kinase) • PGR (Progesterone receptor)
|
ALK fusion • ER positive + PGR positive • PGR positive
|
MVA-BN-Brachyury IV vaccine