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    BIOMARKER:

    MUS81 overexpression

    i
    Other names: MUS81, MUS81 Structure-Specific Endonuclease Subunit, Crossover Junction Endonuclease MUS81, SLX3 Structure-Specific Endonuclease Subunit Homolog (S. Cerevisiae), SLX3 Structure-Specific Endonuclease Subunit Homolog, MUS81 Endonuclease Homolog (S. Cerevisiae), MUS81 Endonuclease Homolog (Yeast), MUS81 Endonuclease Homolog, SLX3
    Entrez ID:
    80198
    over1year
    Downregulation of MUS81 expression inhibits cell migration and maintains EBV latent infection through miR-BART9-5p in EBV-associated gastric cancer. (PubMed, J Med Virol)
    EBNA1 is critical for the pathogenesis of EBV-associated tumors and the maintenance of a stable copy number of the viral genomes. Altogether, these results indicated that the lowering MUS81 expression might be a mechanism by EBV to maintain its latent infection.
    Journal
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    MUS81 (MUS81 Structure-Specific Endonuclease Subunit)
    |
    MUS81 overexpression
    over2years
    MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer. (PubMed, Front Oncol)
    In conclusion, these data suggested that MUS81 regulated ATR/CHK1 activation, a key signaling pathway in the G2M checkpoint, and targeting MUS81 enhanced the antitumor efficacy of talazoparib. Therefore, AZD5153 combined with talazoparib may represent a promising therapeutic strategy for patients with MUS81 proficient gastric cancer.
    Journal • PARP Biomarker
    |
    CHEK1 (Checkpoint kinase 1) • MUS81 (MUS81 Structure-Specific Endonuclease Subunit)
    |
    MUS81 overexpression
    |
    Talzenna (talazoparib) • SRA515
    over4years
    The DNA endonuclease Mus81 regulates ZEB1 expression and serves as a target of BET4 inhibitors in gastric cancer. (PubMed, Mol Cancer Ther)
    Collectively, we show that Mus81 is a regulator of ZEB1 and promotes metastasis in gastric cancer. Importantly, we demonstrate that the BRD4 inhibitor AZD5153 can potentially be used as an effective anti-metastasis drug because of its effect on Mus81.
    Journal
    |
    MUS81 (MUS81 Structure-Specific Endonuclease Subunit) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    |
    MUS81 overexpression • ZEB1 expression
    |
    SRA515